3Q2R


Conserved Protein Domain Family
CAP_GLIPR1-like
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cd05385: CAP_GLIPR1-like 
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CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins
Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.
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Statistics
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PSSM-Id: 349404
Aligned: 11 rows
Threshold Bit Score: 240.001
Created: 15-May-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3Q2R_A        17 DFIKDCVRIHNKFRSeVKPTASdMLYMTWDPALAQIAKAWASNCQFSHNTRLkpphklhpnFTSLGENIWTGSVpi-fsV 95  human
Q9DAG6        40 KFIDAFLNIHNELRRkVQPPAAdMNQLFWDQQLAKLAKAWTRECKLAHNPCIkqryecledYDFIGENIYLGRIet--qP 117 house mouse
NP_001069825  33 RFIEECLRLHNEARTnVSPPAAdMKYMSWDEALAKTAEAWAKKCKFIHNSCSsksfkchptFQYAGENLWLGPLti-saA 111 cattle
P48060        32 DFIKDCVRIHNKFRSeVKPTASdMLYMTWDPALAQIAKAWASNCQFSHNTRLkpphklhpnFTSLGENIWTGSVpi-fsV 110 human
Q6UWM5        32 HFIDNCIEAHNEWRGkVNPPAAdMKYMIWDKGLAKMAKAWANQCKFEHNDCLdksykcyaaFEYVGENIWLGGIks-ftP 110 human
NP_956869     32 EFIRRCVKAHNTHRArVSPPAAgARSMSWDKELAKGARDRARHCKGSHYPSLghfg--hplFGWMGENIWLGSPfsafsV 109 zebrafish
NP_689649     52 DFINEYVNLHNELRGdVIPRGSnLRFMTWDVALSRTARAWGKKCLFTHNIYLqdvqmvhpkFYGIGENMWVGPEne-ftA 130 human
XP_017210734  30 AFIDECVREHNQNRSsVSPTAAnMRYMTWDAALAVTARAWARFCLFKHNIHLreakrvhptFTTVGENIWAGAPysrftV 109 zebrafish
NP_001025914  34 EFIEECVRTHNRFRSgVNPPASnMLYMSWDPDLAKTARGWAKRCEFKHNIYLqepgqahprFTSVGENLWTGSLsi-fsV 112
XP_006011411  34 AFIEECVRVHNFHRSaVKPPASnMQYMSWDRTMAQTARTWARNCRLQHNIHLkehgrlhpnFSTLGENIWVGSSfdafnV 113
XP_007893523  36 AFIKECLDVHNFYRSrVNPSASnMLYMSWDRILSEVAHEWSKKCIFDHNTDLkvpqklhpvFKTLGENIYVTTGsn-lnV 114

3Q2R_A        96 SSAITNWYDEIqdYDFKTRICKK--VCGHYTQVVWADSYKVGCAVQFCPKvsgfd--alsnGAHFICNYGPGG 164 human
Q9DAG6       118 EDVVINWYNESkyFNFDFNTCSE--MCGHYTQVVWAKTVKIGCAVSNCPNlkg------fsAGLFVCNYSPAG 182 house mouse
NP_001069825 112 KFAINMWYDERkfYDFNTRSCSQ--VCGHYTQVVWAYSYKVGCAVAVCPNlgs------pdSALLVCNYAPAG 176 cattle
P48060       111 SSAITNWYDEIqdYDFKTRICKK--VCGHYTQVVWADSYKVGCAVQFCPKvsgfd--alsnGAHFICNYGPGG 179 human
Q6UWM5       111 RHAITAWYNETqfYDFDSLSCSR--VCGHYTQLVWANSFYVGCAVAMCPNlgg------asTAIFVCNYGPAG 175 human
NP_956869    110 ENAVHRWSKEGa-YSVKNNNCSR--LCGHYAQLMWSTSFKMGCAVNVCSKgienf-sthpeSTIFVCNYGDTG 178 zebrafish
NP_689649    131 SIAIRSWHAEKkmYNFENGSCSG--DCSNYIQLVWDHSYKVGCAVTPCSKigh-----iihAAIFICNYAPGG 196 human
XP_017210734 110 KSAVFSWVNELkdYNYNNNQCNDkkVCGHYTQVVWADSYKVGCAVQTCPNgvaethfsniqGVIFVCNYATAG 182 zebrafish
NP_001025914 113 QDAITSWYKEVrdYTYTTNSCSR--ICGHYTQVVWAQSYKVGCAVHFCPTvsyf---sgtnAAHFVCNYGPAG 180
XP_006011411 114 TSAIAAWNNEVqyYNYKTRTCTK--VCGHYTQVVWADSYKVGCAVHICTSgiagf-svgsrSAIFVCNYGPPG 183
XP_007893523 115 TSATKSWYNEVadYNYGSNQCSR--ICGHYTQLVWATSYKVGCAVHTCPSgifhf--nsrlSTIFVCDYGPPG 183
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