Conserved Protein Domain Family
AcyC

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COG2114: AcyC 
Adenylate cyclase, class 3 [Signal transduction mechanisms]
Statistics
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PSSM-Id: 441717
Aligned: 916 rows
Threshold Bit Score: 69.4473
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011957380   84 LSGSTALAERLGVLGREGTELVTDFLNSVFARMIDVIHAYGGDLISFGGDALLVLFDDLDHPRTATCAALDLQRALHGFV 163 
WP_100002534  203 VSVAKGVEPAIEPDRLLLGEQVVRTDIGQTLPLTFYGPRGTIRTISAAAVLNGQFAPDSIENRIVVLGTTVTGGGDVFPT 282 
WP_075793178  170 RDYPALALALVNCCTGSRPLQLGDPGLMRVSFRRDWSAFTIASAADILSGSIDPASASGRLVLVGSSSMSLTDRVATPHD 249 
WP_012866540      --------------------------------------------------------------------------------     
WP_077290838  196 AVAGFLGAPPSVTAEGIRISGRVQSLDLQWQQPLNYYGKGGTIRTVSAQSLLQDAAAAKAALGGRLVLLGVTASAVGDRF 275 
WP_041936330  199 RTASVALGVDPTIERDAIMLGKLRIPTDIGQRLPVTFYGGHGSIATFSAADALDGKLSADAVAGRIVVIGSTVTGGGDVF 278 
WP_099511160  203 SIALKSDPVLQPNGIELGGMPSSTGDGYALPLRFYGPGGTVRTIGANHVLSGRIAEETMRDKIVVIGATVTGGGDTFPTP 282 
WP_099091864   96 PIDRKQLQQIRYEDADKRIEVLASLPAVIRESGVQRDLFVRLCNLLLAGIQHAEGVAIVSMDRSHKRAVALHQERRFEAD 175 
WP_013963880  193 ATLSFSSENAVFGETQLTLGARDIPLDFGFNMPLRYLGPEGSVPTYSARDLISGTAPDALSDKLVVLGFSASAMGDRFAT 272 
WP_106471413  188 LVAAMTFTGDTPVVETDRLRLGDRAVPLDLGQSMPLRHLGPMGTVPTYSASELLTGPLPDALGGKLVVLGYTASAMGDRF 267 
WP_011957380  164 CRVAGVGDFPVYLHVGVESGQVALVSAGQSDSWHYAALGAVVNGVARAESLAGPGEIVLGRRTCELLADVDVVGETLQSG 243 
WP_100002534  283 PFDPVLPGVEVISTAISHLMSGDGIVRDRNIRLVDAGFAVGLPLMLVALLAWRRNVIGLVMIVCAVLAWLAINMAAFANG 362 
WP_075793178  250 ASRPGLDVQAAVLSDLLDHQAGAVPPRWPGRALATAFALTAALLAALAFPRLAALSSVGLLAGLSVLWVGVAYLTAPHDP 329 
WP_012866540      --------------------------------------------------------------------------------     
WP_077290838  276 SSPFDPILPGVEVLSTGIANLLDGSVLLRDSRVRSFDALAAVSITLLGMAVVVFLPLASATIVYLLLLLGWLTVVVICFN 355 
WP_041936330  279 PTPFDPVMPGVEVMSTAITHLVTGDGMVRDRRMRLIDAATAIGLPIVLVSLVAWRRSAAGYVIIVLTLFVWAMLNLSAFA 358 
WP_099511160  283 FDPVLPGVEVLATAIAHLVDGDALVRDNRVRFVDAAMAFTLPILFILLLSWHRSVLGFALIALVSALWIGLTVVAFAHGI 362 
WP_099091864  176 GSLRPSTRLVQNTQEQGRTVVHVWDDANDTDGGYTQHAGFHWAYCTPFVAHASGNSPAVDRNSAADDPADGPLAIYVAGR 255 
WP_013963880  273 PFDENTPGMEVIATAISQLNGGETLRRNAQTRQWDAALAVALTLFCVASVLVWPLSRGVPVAAGFVLVFLASITLAFASG 352 
WP_106471413  268 ATPFGDTTPGVEIIATAISQLAGGPVLRRDARTRRWDVIHAAGLTLLCVLAALSLPLSRGLPVALALVGLSMTGVVIAFA 347 
WP_011957380  244 FFRLNTVVNSITPSGARRFQAGAMk-------TGEtLADLLAdl-dRVS--PYLPSALL------------SRII-AIPD 300 
WP_100002534  363 IWLSAALPMTAAIPPAVIFGAIQLwlg--krrVQH-FARQSK----LLQ--QIQAPGLG------------NWLA-RNpg 420 
WP_075793178  330 GFSTTGPLATNLFLLTLAVPFHWQq------sQQR-SRHLLS----TLR--QYVAPAVV------------QELL-RSNL 383 
WP_012866540    1 -------------------------------mTDYsKEHFGAtvreNFTirQDRSAAFEhaqlsarthletRSLGhPDfe 49  
WP_077290838  356 QGIWLNAALPIAASVPPVVALAVLregfewfrVRR-LVAARE----ALS--RFQAPDLA------------RRIA-DDpg 415 
WP_041936330  359 HGYWLSAALPIAAALPPALAYGAAelwldrgrARH-FAEQSA----LLQ--RIEAPGLG------------EWLA-RDpn 418 
WP_099511160  363 WLSATLPLLAAVPPAILFGAARLWldr---srADS-LTIQSK----TLR--SFQPPSLT------------ERLV-KDpg 419 
WP_099091864  256 SPGEGAKVNQKRIHADVKFTEFIAeivsslqrQRE-LERQQS----GLR--QFFSPPIL------------EALG-QDLD 315 
WP_013963880  353 LWLSGALPLAAALPPAIAASGLRYmqe--nlqARK-SERSVA----SLR--QFQSPALA------------ARIE-SDpn 410 
WP_106471413  348 FGLWMSAALPLVAALPPLTVAGIVrysrerslALQ-TERAAA----SLR--RFQSPALA------------RRLE-NDpd 407 
WP_011957380  301 QPQV---EADLRPVTALFAQVVGLELLAEAL--PPAQSAQLFERYMVAMQSSIARYGGVINKLDvaeeGVKLLAIFGA-P 374 
WP_100002534  421 -fLA---EPVRQDAAVIFIDLSGFTGLSETL--GPNATRELLNGFYKLVDEEVAACGGTITSFM----GDGAMILFGL-P 489 
WP_075793178  384 RDPL---SPRLLDVTTLIADMEGYTGQVESL--SMEQAAVLTREFLDCLTEPVFEHGGTLDKYT----GDGLVAFWGA-P 453 
WP_012866540   50 --dLevgSKRSADMIAVFLDLSNFTGRTFWD--DPDVTADLADAVLSGFIETVSKFGGYPLGLR----GDGLFAGFTPgP 121 
WP_077290838  416 -fLL---VPREQPVAILFIDLAGYTALSEKL--GPARTRDVLKAFHTLVVNEAARNKGLVLDFM----GDGAMIGFGI-P 484 
WP_041936330  419 -fLA---APVRQNAAVIFIDLSGFTGLSENV--GPVAVSEMLSGFFELVDEEARAHGGAITSFM----GDGAMILFGL-P 487 
WP_099511160  420 -fLA---MPVRQKAAVVFIDLSGFTGVSEVL--PLDETRELLRAFHRLVDQEVISHQGFVASFM----GDGAMILFGL-P 488 
WP_099091864  316 TSLL---EPRECDVTVLFCDLRGFSQQAEEQadDLTGLLERVSLALEVMTSQILRFGGVTGDFQ----GDAALGFWGW-P 387 
WP_013963880  411 -yLM---EPIEQDLVVLFVDLTGFTGHSQRL--GQDGTRNLLAMFHKLTAQTVEARGGSVFNYM----GDGALAVFGLeP 480 
WP_106471413  408 -wLA---TPEEQHLVIFFVDLTGFTGLSQRL--GPAGTQELLRAFHGLTNETVGAQGGDVLNYM----GDGALAVFGL-D 476 
WP_011957380  375 AAYED-HAERAAHAALAMQESLHD-VNAHIEAilG--SPddsgarsPtataslL-QQRIGLNPGVVFAGNVGSATRKEYT 449 
WP_100002534  490 EPGVD-DAFNAARCCVRLCDSTRK-WLASLPEs-I--AS-------R------I-GFKMGAHFGTVIASRLGGGSRQQIT 550 
WP_075793178  454 LPVEQ-HADLALDAARAIVERVSR-LSDARQAl-G--YP-------S------L-RVRIGIESGLAMAGDFGTSLRSIYT 514 
WP_012866540  122 KDFT---AVMALGACAFALDAIEReVNPWLESq-G--LA-------R------L-QARAGLDFGPITFIRTGSaHNNEIN 181 
WP_077290838  485 DAGPK-DAADACRCAFDLVVAVRG-WI--LASglD--AE-------I------R-DVRLGGHFGPVVLSRLGHENQQQIA 544 
WP_041936330  488 EPADD-DAARAAACAVSLCERTRA-WLQAHAGf-A--QK-------K------I-GFKVGAHCGPIVASRLGTGDRQQIT 548 
WP_099511160  489 DPSPD-DACHAVEACIALSSHMES-WIAELPEa-I--AS-------R------I-GFKIGAHCGMVIASRLGGDSHQHIA 549 
WP_099091864  388 ISSEE-APLNACRAAMAIREEFAK-AQATP----GhpLA-------D------F-ETSIGIAHGRAVAGKIGTREQVKVT 447 
WP_013963880  481 DRHKS-YADDALASAFDLVHALSR---QSLPQt-P--DE-------A------L-SCRIGLHSGPVTLSRLGAQSHQQVT 539 
WP_106471413  477 RSDRDrAADTALAAAFALVRALAG-LRIDALPe-G------------------LpGCRIGLHAGLATLSRLGADTHQQVT 536 
WP_011957380  450 VMGDAVNIAARVMSAAP--WGDVWCSLVLG-NIAP--R-----IV-CEPR-------------------GSVPLK----- 494 
WP_100002534  551 ATGDTVNVASRLMEVAAshGTELALSTEILqIAGQd-S------A-PYQSgnl-------------tgpLETQIR----- 604 
WP_075793178  515 AVGDSVNTASRLEQAARefTYDVIVGAGTVeRAGR--H------R-FLPL-------------------GERRLR----- 561 
WP_012866540  182 PIGFAANFAAKCEKIAN--SWEVVAGQGLVgLLPD--Er---hF-----Le-----------------hERSPKRytrdh 232 
WP_077290838  545 ATGDCVNVASRLMEVGKsrGASIVLSTALTkAAEAg-G------E-M--Lgmp-------------prrEAVAIR----- 596 
WP_041936330  549 AAGDTINVGSRLMEVAArhGVELALSAEIVrAAGPd-S------R-LTQSgrm-------------egpLETALR----- 602 
WP_099511160  550 AIGDTVNVASRLMEVAAshHADVALSDDLYrAAGNv-R------S-VMELgvl-------------eetLPASIR----- 603 
WP_099091864  448 VFGPVVNLASRLESMTRqlHVPILIDDNLDkLIRK--NpgsfeGR-VRRLlhvlpygmdnslivselvpPESSLP----- 519 
WP_013963880  540 VTGDNVNLASRLMEVAKteKAVVVASSDFAtGLTDggR------RgSAYT-------------------TDVTIR----- 589 
WP_106471413  537 VTGDSVNLASRLMEVAKseHATIVATRDFAdALSK--Pp-----S-PTHE-------------------SRVPIR----- 584 
WP_011957380  495 -GKTEPLELCRVVSERDGG 512 
WP_100002534  605 -GRSGSVIVW-Lw--QSMh 619 
WP_075793178  562 -GKGKATVLYTVIDGAPGI 579 
WP_012866540  233 eT--RSYKFFQC---RWRG 246 
WP_077290838  597 -GRVQELEVA-Lw--TADE 611 
WP_041936330  603 -GRASRIDAW-Lw--RSRt 617 
WP_099511160  604 -GRSGSIPVW-Lw--RRTa 618 
WP_099091864  520 -QLtnkhladfehglqkfi 537 
WP_013963880  590 -GRDGRVQVL-Vw--AADA 604 
WP_106471413  585 -GRAGEVEILAwT------ 596 
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