Conserved Protein Domain Family
HMA_2
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pfam19991: HMA_2 
Heavy metal associated domain 2
This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 180 and 190 amino acids in length. These proteins are distantly related to the HMA domain pfam00403 particularly in the N-terminal half of the family. This family lacks the conserved pair of cysteines found in the HMA domain but does have an N-terminal conserved histidine that may fulfil a similar role.
Links
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Statistics
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PSSM-Id: 437823
Aligned: 29 rows
Threshold Bit Score: 160.82
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFQ04279      31 TPQNvrtaPSTncvipaFACVSALPGRRRYRAAALVGNASLADLLQEGLEKVKGITSVQVNVTTGGILICAeDDSVFKRV 110
EHQ89510      14 DPTLfngfPGT------LEIKHAIPGRIRFFAPSLVQLSKGKELLEERMQAIEGIEQVKVNTISGSIVVLY-REEKIEKI 86 
WP_024267033  24 VKGF----SGI------ISVAHQMPGRMRLTIPSLRTT---SVDIVATLQKIDAIHKVEKNLISASLIITY-DEHQLEDE 89  Salinispira pac...
WP_006806568   2 LPDF----YGV------IEVKHYQKGRLRLQTQVLKENFELKKEFLENINRIEGIVSADVNSVIGSILILF-DENKIESS 70  Pseudoleptotric...
ERK65976       2 LQNF----YGI------IEVKHYQLGRLRLQTDVLKKNTELREEFQNNIKRISGIEKVVVNPINGSILLIF-DENTIEHS 70 
CDE47561      30 LPSF----RGV------AEVRASLPGRMRLYLPAVSANREAAKEMKRQLEATGVVHEVTLNFRLSTALIRY-DETKVEAA 98 
SFE23639      40 IPSF----KNV------IEVRSAIAGRVRFYIPVLKSNHSLANNFITQIKQLPLIKKCEINTLTGSALFEY-DEKNLDAQ 108
CCY49784      34 LPSF----KHA------IEVKSSIPGRVRFYVPSLESNIEAANDLVEQMGKIPVIKSCKVNLVTATVLVEY-DHENLDPN 102
EFM64083      40 LPSF----KNA------LEVKSSIPGRVRFYAPVLVGNIEVANHFVDQISKIEVIKSCRVNTLTGTIVMEY-DHQQLDPQ 108
SDY74676      22 RSYTvgmgEKQ------LQVSHALPGRIRLHHMVFMHPVS-GKALAERLQQVKGIHQVSINPKTGSLLISY-DSGEMKEE 93 

EFQ04279     111 EvfLEGrfflspCVREPIMRTQMPHRQPASEYKHTLQEVMGTMSDYIYERTHRLFDLRSLVSFILIVRGIRRM--VTLDE 188
EHQ89510      87 L--ILG------IIIKLLGLENKLQTKEVPLVRKEIRKWNEALSYSLYEKTRGLLDVKAALSLVFLFYGIKGLffSTEIA 158
WP_024267033  90 I--LFG------AVIQIMGLEGEIDKPVRPAAIHHIQQIIDSLNRGIYEYTGGHLDLYHSVPLILIGLGAYQFikTRKLL 161 Salinispira pac...
WP_006806568  71 F--LYL------VILKILHLEEEAFKSKPTKIKIFLKNVFEVLDLSVYNKSKGLLDIKTIVAGLLAYYGIESL--RGVKS 140 Pseudoleptotric...
ERK65976      71 F--LYL------VVLKLLHLEEEIFKMKSSKTEVALKKLFEVLDLAIYNKSRGFLNVKTVLAGVIGFYGIKKL--RASNA 140
CDE47561      99 V--VQG------AVLKLMGLTDALQKEPVSRIQSGLNTLMAAINHGLLEATNGLLDVRTLAGCALTFAGVKSLa-VSGAA 169
SFE23639     109 T--LEG------AVIKLLELDKLINGNKESSIEKEIRNISQAVNNGIYDYTNGKLNTKTLILIALVVGAFYQIrrNGCII 180
CCY49784     103 T--LEG------AIIKLLGIDKTILEKRVSRMRSEGSKLLDTANNAIYDFTNGILDLKTLVATIFVIYGIKDYrkSRGNC 174
EFM64083     109 T--LEG------AVIKLLGVDRSIDEGRVSEVKKFSEKVFAAVNNGLYDFTNGLLDVKSLASLSLLVAAIFDRrrYGGGR 180
SDY74676      94 I--LTA------AIYQLLGYGSLDDSKASAKISEEVHYMHQAANHALMQKTSGAMDIHTLLAGGFLAVALKEYwkTKSLG 165

EFQ04279     189 MPSGPQMLWWAVAL 202
EHQ89510     159 KANPYSLLYWAYRS 172
WP_024267033 162 LPGALTLMWWGFSS 175 Salinispira pacifica
WP_006806568 141 VPSGISLLWWAYIL 154 Pseudoleptotrichia goodfellowii
ERK65976     141 ILSGWTLLWWASSL 154
CDE47561     170 VPGAMTLLWWAASI 183
SFE23639     181 RPDYLTLLWWSRSI 194
CCY49784     175 APGAANLFWWGSQV 188
EFM64083     181 MPGYPTLCWWSTRL 194
SDY74676     166 TPAPITLLYWSYRM 179
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