Conserved Protein Domain Family
PRK08645

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PRK08645: PRK08645 
bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed
Links
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Statistics
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PSSM-Id: 236321
Aligned: 114 rows
Threshold Bit Score: 705.453
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
251797752   2 KPDLRTKL--KQRILTGDGAMGTYLY-QMGFPVGVSYEELNMTRPDVIEGVHRRYYEAGARVIETNTFSANLVKLSKYGL 78 
15893583    3 NTVIREYI--KNNVLVTDGAMGTYYSkTTGDYNNFC-EFANLTNPEVILNIHKEYIKSGAKLIRTNTFSANTLTMDIS-- 77 
302873410   1 -----MNL--NERLLIFDGAMGTYYAsSCNNPLPKC-ELANIHDKKTILNIHKEYIKAGAGAIKTNTFGANKISLECD-- 70 
150016701   1 --MIKELL--KNDILICDGAMGTYYSeVTGNDVSYC-EFGNLNDKETIKRIHKEYIEAGAKLIRTNTFSANTYDLGVS-- 73 
153954387   1 -----MNI--KEKPLIFDGAMGTYYPrISKDPLPKC-ELANIYDRNTILKIHREYIEAGCMAIKTNTFGANKVSLESD-- 70 
219854978   1 -----MNI--KEKPLIFDGAMGTYYPrISKDPLPKC-ELANIYDRNTILKIHREYIEAGCMAIKTNTFGANKVSLESD-- 70 
134299604   1 --MIREYL--KNNILITDGAMGTYYA-QITGKYNVFPEFANINEPEIIERIHTEYINAGAKLIKTNTFSANSRVLKI--P 73 
238917210   7 AGILYDRL--KSEILVADGAFGTYYAkKYD--TGSLPELANLQASDRVLAIHKEYIEAGAKIIRTNTFASNTVCLGAG-- 80 
146296190   1 MKSFREFLs-QQDIVLFDGAMGTELL-NRGYNKDFPLEWANISNPDLVKSIHSDYILAGSQCIETNTFGANECRLNLYGF 78 
222528356   1 MKKSFREFlkEQAIVIFDGAMGTQLL-LRGFSVDFPLEWANVANPELVKQIHTDYILAGATCVETNTFGANECKLKVFGF 79 
251797752  79 EPDMEAINRAGVRIAKAAAg-EDAYVV-GAVGSIRAgKlK---DVRTSEVSHAFERQLDALLVEGVDGILFETFYDFDEM 153
15893583   78 KTELENIITKGYMIARKAAegKEIFIA-ADIGPINKfe----iEKPVEYIIEEYKFVVDIFMNLGADIFVFETLSSIDCL 152
302873410  71 FDVMKEAIVSGYEIAKEATegTDVLVF-ADIGPIPF--------LEKVDLWVGYKEIIDIFLSLGASNFIFETFSSDEYL 141
150016701  74 LETLMDIIKSGINLAKEVTr-NTSVLIgASIGPIKTdn----lDEFSNEVLEEYKYIVDCFLKNGIDIFIFETFSNYNCL 148
153954387  71 FNKVKEVIINGYEIAKEAAkdTEVLVF-ADIGPIPF--------LESMDLYEGYKEIVDLFLELGAKYFIFETFSSDEYL 141
219854978  71 FNKVKEVIINGYEIAKEAAkdTEVLVF-ADIGPIPF--------LESMDLYEGYKEIVDLFLELGAKYFIFETFSSDEYL 141
134299604  74 KSEVKKIVLAGLDLANKVAqgKSIFIA-ASIGPIPEm--FdkmETDQENSLDEYKFIVDIFLNSDIKIFMFETFSDVSDL 150
238917210  81 FDEVRNNIKNAVDIAREAVkgTDVLVA-ADIGPIPGe-----nMIEKEHIEKEYVDIVNVFKECGVDIFVFETFPELGFI 154
146296190  79 EGQVEKINRNAVKIAKEVAg-QTAYVI-GSVGPLGK-PvGsgfEIDDKRAKEVYKKQLYFLLDEGVDAILFETAASTHEV 155
222528356  80 ENEVERINRSAVRIAKEVAe-NKVYVI-GSVGPLGK-PvGngfEIDDKKAKDVYKRQLYFLLDEGVDAIIFETAASTHEV 156
251797752 154 RLALGLARKLTq-LPVICQFAAQDVGRTQDGTGLLDAFTLLKDEG-ADVVGFNCRSGPNGIMRAVESI-GGp-VELPLSI 229
15893583  153 KEVFQYIKRKNknAFILAQFAIMQDGFTREGISVNSIVNKIKAIGsIDAYGFNCGSGPAHLYNIIKGL-DI--YGDIIST 229
302873410 142 IEISEYIKEKNskAFILTEFAVSPEGVTRLGKSGKKLLNTMLKAKtIDACGFNCFSGPYHLLQYSKTL-DI--KDKTISM 218
150016701 149 KKISEYIKYKNidSFILTQFAVKPDGFTRDGLSAAKLIKEVRNTKyIDAFGFNCGSGPAHILEMVKKI-NI--ENEIVSV 225
153954387 142 REISEYIKGKDpeAYILMEFAVSPEGYTRVGKSGKKLIENILKIPtIDACGFNCFSGPYHLLQYIKTF-NI--GNETISV 218
219854978 142 REISEYIKGKDpeAYILMEFAVSPEGYTRVGKSGKKLIENILKIPtIDACGFNCFSGPYHLLQYIKTF-NI--GNETISV 218
134299604 151 LEITKYIKVKDssAFIVTQFATTPEGFTRKGLSNKHIIAEVKKSKsIDAYGFNCGVGPTHLFNSLKKL-NF--ADDMVAA 227
238917210 155 DKAIENAGENG---FVITQFAINQFGYSSAGFSARKLIEEAGKNSyIDACGFNCGVGPGHMKKLVQSL--InrNDKYFAV 229
146296190 156 LIAIEALKELDsnFPYIVQFSFTRDLTTIYGEDIYKVIEFLKGID-ADVVGLNCGNGPHQTLEALKIFsQH--LKGPFSV 232
222528356 157 QIAIEALKELNdkIPYIIQFSFTKELSTVYGEDIYRVIEFLKSTN-ADVVGLNCGNGPQKTLEALKIF-SQh-LKGPFSV 233
251797752 230 FPNAGIPDYVDGKYKYSA-GPDYFAETALQFADRGARIIGGCCGTTPEHIAAMAKALK-DYK----Pqngaaavaiadsp 303
15893583  230 LPNAGYPEIINERMVYVD-NPDYFADKMSMIKNRGVKIVGGCCGTTPKHIEKMVSNLKeNLI----N------------- 291
302873410 219 MPNSGYPSMINNRVFFDN-TKEYFAEQMLEIARQGVTILGGCCGTTPEYIKEMVDKLK-GLE----Vhnilndgr---qi 289
150016701 226 LPNAGYPEIIHERTVYPN-NPVYFAKKVNEIRSFGVSIIGGCCGTNPSYIKQLTQIVNeNSK------------------ 286
153954387 219 MPNSGYPTVIDNRTFFDN-TKEYFAQRMLEIAKQGVSILGGCCGTTPEFIRETVIKLK--------K------------- 276
219854978 219 MPNSGYPTVIDNRTFFDN-TKEYFAQRMLEIAKQGVSILGGCCGTTPEFIRETVIKLK-KLS----K------------- 279
134299604 228 APNAGYPEIVHERMVYIQ-NPNYFAEKMKDISGLGVKILGGCCGTTPIHIEKMSELIQsYLNa---P------------- 290
238917210 230 LPNAGYPQVVSGRMVFDDnNAAYFSQIMHDLAEDGADIIGGCCGTTPEYIRQMVLKTAdVVHmknaS------------- 296
146296190 233 QPNAGYPQLVQGRLVYST-SANYFASFVDEYVKYGAKIIGGCCGTTPEHIKAIKERIK-TIS----K------------- 293
222528356 234 QPNAGYPQLIQGRPVFST-SANYFASFVPEYIKLGAKIIGGCCGTGPEHIKAVKEKIK-EVS----P------------- 294
251797752 304 eaeiiVIEAEPAEVVKNASGEradTPIN-SEPSLVDTVRVRHA-VIVELDPPRDLDITKFMAGAAAIKACGADAITMADN 381
15893583  292 -----IEEIEIKKNKGINNYK--------KKNSFTEKLDKGEFpIVVELDPPFDTNIDKIMYAAKVCKQNNIDLVTIADS 358
302873410 290 ettegLKQEKLQEKKALTEEVk--DEKRvNKNPLLEKLERGEKiIAVELDPPINTEIDFFISGAKRLKGQGIDAITIADC 367
150016701 287 -----VVNANAKAEPKVKSFEk------kAKNTFKDKLENGEFvVAIELSAPIDTDISRIIDGAKICKENNIDLVTVPDS 355
153954387 277 -----LSKSEIVLKKQAEKIH---TEKPvVKNVLLEKINKGKKiIAVELDPPIDTEVDFFLNSARTLKEQEIDAITIADC 348
219854978 280 -------SEIVLKKQAEKIHT---EKPV-VKNVLLEKINKGKKiIAVELDPPIDTEVDFFLNSARTLKEQEIDAITIADC 348
134299604 291 -----IPKQQISAKPKVIIDRe-------KTDGFFEKMRKGKFvIAVELDPPFNADTDLILQNAWICKDHGVDAITIADS 358
238917210 297 -----IEEEI--------------SEKKtANDVSFYKGKEGRKlIAVELAPPLGIDDEKIMDAAFLMKESGVDVLTFPDS 357
146296190 294 -----SVEIEVIEKKEEQKSIlkdTPSE-LSQKLGK-----KFvFTVEISPPKGIELEKTKEGVKLLKEAGADTVNIADS 362
222528356 295 -----SIEIEVVERKEEQKAV-----LKdTPSELSQKLGKKFI-FTVEISPPKGIELEKTKEGVKLLKEAGADTVNIADS 363
251797752 382 SLAVTRMSNLALAALVKERIGLRPLVHIACRDRNLIGTQSHLMGLDALGIDHVLAVTGDPARFGDLPDSSSVYDLTSFEM 461
15893583  359 PMSKVRVDSVMIASKIKRELGIEVMPHICCRDKNVNAIRSSLLAAHIEGIRNILAITGDPVTGIDKVNTKSVFNLNSYKL 438
302873410 368 PIARARVDSSLLACKLKRELDITAIPHMTCRDRNINATKALLLGLNVEGINNVLVVTGDPIPSADREEIKGVFSFNSSIL 447
150016701 356 PMSKVRADSTIISSKIKREIGIEAMPHVCCRDKNTNAIRSSLIGSHIENIRNILAITGDPISDASKVETKSVFNLNSFRL 435
153954387 349 PIARARVDSSLLACKLKRELDITTIPHMTCRDRNINATKALLLGLNIEGVNNVLVVTGDPIPSAERDEVKAMFSFNSAIL 428
219854978 349 PIARARVDSSLLACKLKRELDITTIPHMTCRDRNINATKALLLGLNIEGVNNVLVVTGDPIPSAERDEVKAMFSFNSAIL 428
134299604 359 PMARARADSIMIAAKIKREVGIEVLPHLCCRDKNLNALKSALLAGYIENIRNVLAITGDPVAIADKNDIKGVFNLNSMKL 438
238917210 358 PSGRTRADSILMAEKVSRETGMCVMPHICCRDKNAIAMRSQLLGAHINDINNFLVITGDPIPSVVRASVKSVFNFDSVGL 437
146296190 363 PMARVRISPIALAHILKEELGVESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGDPPSIGDYPQAKPVFDVNSEGL 442
222528356 364 PMARVRISPIALAHILKEELGMESILHFTCRDRNLISLQSELLGAAALGVKNVLALTGDPPSIGDHPQAKPVFDVNSEGL 443
251797752 462 IRMTKQLNDGIAFSGKPLKQKAKFVVGAAFNPNVKHLDKAVQRLEKKIASGADYIMTQPVYDPVLIEKIAEATKHLPVPV 541
15893583  439 MNLISEMNKET-------FKEDKISIGGALNLNVLNKEVEVTRMLKKVENGGTFFLTQPIFKEETIEFLAKLKKDRNIKI 511
302873410 448 SSYIRELNET--------TFSSPFNVCGALNLNVRNFSNELEKAQKKIDNGITMFLTQPVLTEEAMENLKLARKKLNAKI 519
150016701 436 IELIESMNEEI-------FKEDSIYVGGALNLNVLNKEVEYNRMMKKIEKGAKFFLTQPIYDDNAIEFLKMIKERTNVKI 508
153954387 429 ANYITNLNDT--------IFSSPFNICGALNVNSRNFNTELKRAKTKIENGIAVFLTQPILTEEALENLKLARRELTARI 500
219854978 429 ANYITNLNDT--------IFSSPFNICGALNVNSRNFNTELKRAKTKIENGIAVFLTQPILTEEALENLKLARRELTARI 500
134299604 439 IQLISTMNKEL-------FPEDPINVGGALNLNLLKPEAELAKMVKKINSGATFFLTQPIFEDYVINILRLINKNDGIKI 511
238917210 438 MNIISDMNQE-QFAGKPV------IYGGAINQGRVNFKVELERVKKKMEAGATFFMTQPVFSDEDIDRLRQIKEQTGARI 510
146296190 443 VLILNKLNSGTDYMGNPIGKATNFTIGVALNLNADDLDKEIERLKRKIENGAHFIETQPIYEVEALEKFFEKVDFKLPPI 522
222528356 444 VLILSRLNNGTDYMGNPIGKATNFTIGVALNLNADDLGKEIEKLKHKIENGAHFIETQPIYEPETLERFFEKVDFKLPPI 523
251797752 542 FIGIMPLASGRNAEYLHNEVPGIQLSDEVRKRMAGL-EgAEGRAEGVRISRELLDTAIRHFKGIYFMTPFMFYEMAAELT 620
15893583  512 IGGVLPIVSYRNIQFINNELFGVDIPKEYIERFSVDmTrQEAEEVGVNLARELIAKIRNYVDGIYIVTPFNRIGMVMKIL 591
302873410 520 LGGIIPVVSYRNACFMNNEISGINVSEEIIERYKDVs-kEEATRLAVEISTGIATEMSSYVDGFYIITPFKRIDIVSEIV 598
150016701 509 LAGLLPVVSYRNAMFLNNELPGVTIPDKYVQMFSENmSkEEAQEIGVKITVEIGKKLKGIADGLYFITPFNRVNMLIEII 588
153954387 501 LGGIIPVVSYRNACFMNNEISGIRVSEEIIKQYKDVs-kEEAVKLAVKISTDIAEQIYPYVDGYYLITPFKRIDIISEII 579
219854978 501 LGGIIPVVSYRNACFMNNEISGIRVSEEIIKQYKDVs-kEEAVKLAVKISTDIAEQIYPYVDGYYLITPFKRIDIISEII 579
134299604 512 LGGIMPLVSYKNALFLNNEVAGIKIPERIINKYNSNmGkDEAEIIGIEIAVEIANKIKESVDGFYFITPFNRVEMIMKII 591
238917210 511 LCGIMPFVSLRNATFMKNEMTGINVTDEILSRYRADmSkEEGEETGIQIAREIIAKTTDFVDGYYFSFPFNRVHMLKKII 590
146296190 523 LGGILPLRSSRHAEFLHNEVPGITIPDKIRERMKNSk---DPVKEGIEIACEIVDRIKEMVSGIYIMPPFEKYEMAAEII 599
222528356 524 LGGILPLRSPRHAEFLHNEVPGITIPDKIRERMRTSk---EPAKEGVEIACEIVEKIKHMVSGIYIMPPFEKYEMAVEII 600
251797752 621 DYVWA 625
15893583  592 ENVRK 596
302873410 599 SNIKN 603
150016701 589 KQINA 593
153954387 580 NNIKA 584
219854978 580 NNIKA 584
134299604 592 KKLKC 596
238917210 591 GKNNQ 595
146296190 600 KRFRV 604
222528356 601 RNFKI 605
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