4K1C,4KPP,4K1C,4KJS,5HYA,4KPP,5HYA


Conserved Protein Domain Family
Na_Ca_ex

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pfam01699: Na_Ca_ex 
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Sodium/calcium exchanger protein
This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Statistics
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PSSM-Id: 426387
Aligned: 91 rows
Threshold Bit Score: 39.8934
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4K1C_A   257 SSLVILLGTTVIISFCADFLVGTIDNVVestGLSKTFIGLIVIPIVGNAAEHVTSVLVAMKDK---MDLALGVAIGSSLQ 333 Saccharomyces cerev...
Q32GZ0    38 vvIAINLLALIGILSSAFSVVRHADVLA---HRLGEPYGSLILSLSVVILEVSLISALMATGDa-aPTLMRDTLYSIIMI 113 Shigella dysenteria...
BAF89034  64 SGILLAIVLIPVIFGAIFAAVYHAEVIG---HATGEPFGTLVLTAAVTIIEVALIASVMLSDDggsPELARDTVFSVVMT 140
Q740P8    32 LGPVLVALAALFLIGAVVAAVHHAEVVA---HRIGEPFGSLVLAAAVTIIEVALIVELMASGGnetATLARDTAFAALMI 108 Mycobacterium avium...
O53910    27 IGPVVGLLAAVLLAGAVLAAVNHAEVVA---ARVGEPFGSLVLAVAVTTIEVALIVALMVSGGddaATLARDTVFAAVMI 103 Mycobacterium tuber...
Q9RXE0    23 PPLWVFFTATIAIIPLADWLRQATEQIA---ERVGQTIGGLLNVTFGNLAELIIAIFVLLSGN---AVVVKAQITGSIIG 96  Deinococcus radiodu...
4K1C_A    64 SHTLTFLFNFLAIIPLAAILANATEELA---DKAGNTIGGLLNATFGNAVELIVSIIALKKGQ---VRIVQASMLGSLLS 137 Saccharomyces cerev...
O59768    81 NAKSVFILNMLAIIPLASLLSFATEQLS---IISGPTLGALLNASFGNAIELIVGVLALKRGE---LRIVQSSLLGSILS 154 Schizosaccharomyces...
4KJS_B    25 PSAVLFAVYCVTIIALASYMGRATESLS---IIAGPRIGGLLNATFGNAVELIISMFALKEGL---TGIVLASLTGSVLG 98  Bacillus subtilis s...
P74072    27 GETTVFILAGLAIVPLAAFMGTATEEIA---VVIGPNAGGLLNATFGNATELILAYIALKEGL---IEVVKATLTGSIIG 100 Synechocystis sp. P...
4K1C_A   334 VALFVTPFMVLVGwmIDVP--MTLNF-STFETATLFIavflSNYLil-----------------------dGESNWLEGV 387 Saccharomyces cerev...
Q32GZ0   114 VTGGLVGFSLLLGg-RKFAtqYMNLF-GIKQYLIALFplaiIVLVfpmalp---------------aanfsTGQALLVAL 176 Shigella dysenteria...
BAF89034 141 VCTGLTGICILGGg-LRFKe-qVYETtGAGAYLTVLIvlvtLTLVlpnytqg------------tpgpfysSSQLAFFSV 206
Q740P8   109 TTNGIAGLSLLLGs-RRYGv-tLFNAeGSGAALATLTtlatLSLVlpafttt------------qvgkefsPGQLTFAAV 174 Mycobacterium avium...
O53910   104 TTNGIAGLSLLLGs-LRYGv-tLFNPhGSGAALATVTtlatLSLVlptftts------------qsgpelsPGQLIFAGA 169 Mycobacterium tuber...
Q9RXE0    97 NALLGLGLAILIGs-VGRQr-qKFSWqNAGQLNSMLVlv-tIALLipalfdyterlpgfaagsdlarsdldERLSLAVAV 173 Deinococcus radiodu...
4K1C_A   138 NLLLVLGLCFIFGg-YNRVq-qTFNQtAAQTMSSLLAia-cASLLipaafratlph----gkedhfidgkiLELSRGTSI 210 Saccharomyces cerev...
O59768   155 NLLLVFGMCLVTTg-IRREi-tTFNItVAQTMIAMLAls-tATILipatfhyslp-------dnansenalLHVSRGTAV 224 Schizosaccharomyces...
4KJS_B    99 NLLLVAGLSFFVGg-LKYAr-qEFNIhDARHNSGLLIfaiiVAFVipevfsv------------gmgnaskLNLSIGISI 164 Bacillus subtilis s...
P74072   101 NLLLVMGFAVFLGg-LRYKe-qNFQPlAARLNASTMNlg-vVAILlptalqyts---------tgveetvlQNLSVAVAV 168 Synechocystis sp. P...
4K1C_A   388 MSLAMYILIAMAFFY 402 Saccharomyces cerevisiae S288C
Q32GZ0   177 ISAAMYGVFLLIQTk 191 Shigella dysenteriae Sd197
BAF89034 207 LTLILYGVFLYIQMV 221
Q740P8   175 ASLLVYLLFVFTQTV 189 Mycobacterium avium subsp. paratuberculosis
O53910   170 ASLGLYVLFLFTQTV 184 Mycobacterium tuberculosis
Q9RXE0   174 VLIAAYALNLVYTLV 188 Deinococcus radiodurans
4K1C_A   211 VILIVYVLFLYFQLG 225 Saccharomyces cerevisiae S288C
O59768   225 IVLIVYVLLLVFQLK 239 Schizosaccharomyces pombe 972h-
4KJS_B   165 IMILLYVAALYFKLV 179 Bacillus subtilis subsp. subtilis str. 168
P74072   169 VLIGVYLLSLVFSMG 183 Synechocystis sp. PCC 6803 substr. Kazusa
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