Conserved Protein Domain Family
TFP_LU_ECD_Twit
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cd23593: TFP_LU_ECD_Twit 
extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar proteins
Twit is a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the bone morphogenetic protein (BMP) pathway receptor encoded by Wishful thinking (Wit). It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions. Twit contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467122
Aligned: 29 rows
Threshold Bit Score: 87.4615
Created: 21-Oct-2021
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_610067     33 HLQCWHCSSDTIgaedfCDVTFQedniptdlikerninLLRSCNGTins------dhERAVCRKTVEENNGk-lITKRFC 105 fruit fly
NP_001156181  26 AINCWVCSTDTDq---rCNDPMNmt-----------kgAIEDCSRAphs------afLQPVCKKQKQRVNGe-lLIIRSC 84  pea aphid
AGM32695      21 GLRCWSCTSSREh---hCGDPFNst-----------ffRIEDCDYNfspnt--ynqpSTTVCKKQKQIVNGq-eQVIRSC 83  Formosan subter...
VVC90377      22 GVRCWSCSTDLDptnpeCNDPFLpgqtl-----npgyfRLENCDANagaty-pyltsSKTACKKQKKIVNGq-lVVSRGC 94  Leptidea sinapis
AKK22143      31 RLRCYHCTSDHYnp--nCDDPFNst-----------giEVVDCLEQtrrr---sdprEVPVCKKIKQRINNgdlQTVRSC 94  migratory locust
GBP74002      82 SIRCWTCSSDNDp---mCQDPFRaeqnq-----ysnhfILTNCDANvnpnygfsnnpSRSVCKKQKTYVNGq-lITVRSC 152 Eumeta japonica
XP_026286450  22 ALRCWSCDSQNDy---aCDDPFRtan----------rfALIECDNRaaqgp--ayyhGYPVCRKVKQRIDGr-pLVIRSC 85  western flower ...
AKK22142      25 TLRCYTCSTVANk---nCGDPFNks-----------yvPMTDCQSVgvtg---aqpkEVPVCKKVKQRVNNgdlQTVRSC 87  migratory locust
RZF37015      31 SVHCWVCSSDVDp---rCGDPFNmt-----------hfAITDCNRDrmas---sylgSVGTCKKLKQIVGNe-vTVIRSC 92  small brown pla...
XP_021922381  21 GLRCWSCASSSDr---hCGDPFNkt-----------ffHLRDCDSDrspqt--ynrlTTPVCKKLKQLSNEq-eVIERTC 83  Zootermopsis ne...

NP_610067    106 YYtnks-dpvELCNITspeknVRRIFCEdCL-TDRCNGA 142 fruit fly
NP_001156181  85 AWasdsrsddGPCAINtp-anIRIEHCStCD-QDLCNGA 121 pea aphid
AGM32695      84 EYkk-----eTACIQShahtpVKVVSCEtCSnDDGCNTA 117 Formosan subterranean termite
VVC90377      95 TWkrqd-dysTTCPTTsngpnEVTTFCEtCD-YDGCNGA 131 Leptidea sinapis
AKK22143      95 AVml----pdQSCTTTdqssyIHEEYCItCD-TDLCNAA 128 migratory locust
GBP74002     153 SWkard-dytTSCPNNr---aDNYAFCEtCD-YDACNSA 186 Eumeta japonica
XP_026286450  86 GWvdpndggrSACNQLstpgyIHQEYCSiCN-SDACNSA 123 western flower thrips
AKK22142      88 AWvk----peEPCPPSpsgayIREEECStCT-SDLCNAA 121 migratory locust
RZF37015      93 HWdtndrspsDSCQTTs---yAKVEHCStCS-TDTCNAA 127 small brown planthopper
XP_021922381  84 VWnk-----eTACAPSsvhtsVKDVFCEtCA-EDGCNSA 116 Zootermopsis nevadensis
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