2IX0,2WP8


Conserved Protein Domain Family
RNB

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smart00955: RNB 
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This domain is the catalytic domain of ribonuclease II.
Statistics
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PSSM-Id: 214935
Aligned: 349 rows
Threshold Bit Score: 115.057
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2IX0_A        208 REDLTALDfV-TIDSASTEDMDDA--LFAKALpdDK-LQLIVAIADPTAWIAE-GS----K-LDKAAKIRAF-TNYLPG- 275  Escherichia coli
NP_892965     238 RLDLSSKNsY-MFKSWETENSPILpiFQIDKIk-nNsYKLWIHTNTIAERLDLiNK----K-SLQIFFDRFE-SFPLLE- 308  Prochlorococc...
YP_001011237  238 RLDLTNKNsY-MFKSWNGENSPTLpiFQIDKNkdDs-YKLWVHTNTIAEKIDL-SS----K-KGLEVFFNSFeSFPLLE- 308  Prochlorococc...
YP_001484255  238 RVDLTDKNsY-LFKSWNSNNSPMLpmIQIEQGknKGtL-LWIHTNNLAERVDL-NS----KkSLEILFNGFE-SIPLLN- 308  Prochlorococc...
XP_001386742  388 IYALPs------LKASNKKSADSFlaISLEKLnsRk-YVINVHIPDIITKIAP-NSnlfnS-LATNSTSMCS-MSRMVDg 457  Pichia stipit...
XP_637628     629 RVIFNENLpvvaLDNKTTIAVDDAfsIDFNSSdt--fDKLYVHIADVSRWIPQ-EQ----Q-QEQQQQQRQQ-EEVQKEe 699  Dictyostelium...
YP_001227736  237 RDDLTALPtv-lLQGWSAKDAPLLpaVSLEALdd-gaQRLWVHTPSVAERLAL-ES----P-LERWLRQHGE-ALSLGS- 306  Synechococcus...
YP_001224829  239 RVDCTDQPal-lLTGWSATDAVSLpaLHVIPHeg--gTRLWIHAPAVAERLAP-GN----S-LDQWLLNQSE-SICLGQ- 307  Synechococcus...
YP_001014865  240 RSDLTAQPsl-lFESWESTNSPSLpgLYAQPye--ggNRIWVHAPTISERINL-GG----K-LDRYLKDKGE-VICLGN- 308  Prochlorococc...
NP_875380     238 RNNLESQPci-lFKSWSSKNCPLLpaLYSEPsn--ggMTLWIHIPTIGERLNY-GS----K-LDEWIRNRSN-SICFGE- 306  Prochlorococc...
2IX0_A        276 FNIPMLP------------RELSDDLCSL-RANEVRPVLACRMTLSADgT-----------IEDNIE--------FFAAT 323  Escherichia coli
NP_892965     309 KWQNYLS------------DEICN-AAKF-NINEINDAISLCIEMNSE-N-----------EIINWS--------FHLTK 354  Prochlorococc...
YP_001011237  309 KWQPYIS------------EEICN-SSKF-NVGEINEAISLCIDINTE-N-----------EITNWS--------FHLTK 354  Prochlorococc...
YP_001484255  309 DWQNYLS------------RSIIND-SEF-KLDEKNEAISLCLHLNSD-N-----------EIVDWS--------FHLTL 354  Prochlorococc...
XP_001386742  458 TSANELFspkiieefkfknQNLNDKSADMfQVGDIAIKKSSNSKLTSDsTcitisytyntyEGNPFAnipekisvSFDSL 537  Pichia stipit...
XP_637628     700 QESVLNNil---------yKTSFMNLKSTyFPQGTYHLFPPELILSIS--------------LSSAS---------KERP 747  Dictyostelium...
YP_001227736  307 SWISLLP-------------ATLHKAAAL-VAGKSQDALSVALDLSADg------------TLQHFR--------FCRSQ 352  Synechococcus...
YP_001224829  308 HWLPLLS-------------PALTKASAF-RVGEVQDAVTLRLDLSADg------------EWKDWD--------FSLTR 353  Synechococcus...
YP_001014865  309 NWLEFLN-------------ESLRSASQF-KINEECEAISLMIDINADg------------NITDWK--------FTLSI 354  Prochlorococc...
NP_875380     307 EWQCFLG-------------DKLNKEAGF-EIGKSNSAITLELFIDKNg------------KCQSWE--------FYLST 352  Prochlorococc...
2IX0_A        324 IESKAK-LVYDQVSDWLEN-TGDwqp-------------------eseAIAEQVRLLAQICQRRGEWRHNHALvFKDRPD 382  Escherichia coli
NP_892965     355 VKCSLL-VENQHIDALLTRkSKAritsri--------------lkpikDYIEDLDKIIEISNEFRKNQLLDGKiELPKSN 419  Prochlorococc...
YP_001011237  355 VKCTLL-VENKHLDALLTRkSSTritsri--------------lkpikDYIEDLDKIIEISKFFRTKQILHGKiEIPKPN 419  Prochlorococc...
YP_001484255  355 VKCSLI-VGSDHTNALLSRkSKTritsrv--------------lkpikEHIDDLDKILEISCSFRKKNLLEGKvEIPAPL 419  Prochlorococc...
XP_001386742  538 SSVTIKnLGWQDLEDSLNGkSEVspfrlfrsrskkdtyngndrllvtnEDSHNLNFVYSVMRTHFKIRNLAGSsQINPAV 617  Pichia stipit...
XP_637628     748 ISAITVeMNFLKGSGKIDSy---------------------------kIYPTYLTNVVSLTKGQATRYIEDSLnSIKSDG 800  Dictyostelium...
YP_001227736  353 VQVDGV-LDRKGLAALLARkPKArttpaa--------------lkslkDHLPLLEQLQALVELLRQQRLATGGlELDLPV 417  Synechococcus...
YP_001224829  354 IRPVAQ-ITQTHLEALAGRkPKSraipad--------------lkaikEQISQLETLIFSAKSAHESERSAGLiELDLPR 418  Synechococcus...
YP_001014865  355 IKPVKI-ITPKHLTAINNRkAKSksvpia--------------lkgikDNLEVLYTLLHSAKIINN--MNNNSiKLDEYI 417  Prochlorococc...
NP_875380     353 IKPVAK-VSQKNLDDILKRkKRSrivpas--------------lkllkDYINNIEDLLYISKIINENLIKAGLiQLDLPV 417  Prochlorococc...
2IX0_A        383 Y------RFILGE-------KGE---VLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGF-GIYNVHMGFDPANAdA 445  Escherichia coli
NP_892965     420 NnieslkEILVHN-------PAEf-sKEYFEPLNNNDIQTYLSPLLYEANSIWFNHSNNYGLN-NASYISQELDYINVtE 490  Prochlorococc...
YP_001011237  420 Sn-----IDSLREllvhnpvDYS---KEYFEPLNNNDIQSYLSPLLYEANSLWFKHSNKYGLI-NASYISQELDYINIsE 490  Prochlorococc...
YP_001484255  420 Nk-----INSLEEffihnpaEYS---KGYFESLNKEDCQTYLSPILHEANLIWYKHSIQYGLK-SAGYISKGLDYVNAnE 490  Prochlorococc...
XP_001386742  618 Endv-edASSLTK-------ELNiinSNRPEEKHYEKSRFFMAELELFAANLTSNYCEYNDIP-VLTVRQELMDEDGDnA 688  Pichia stipit...
XP_637628     801 Dt-----VIESFS-------VG------QKLLYDAYDLLNRRKQFRIENNKNLENFSRIPNDKnSLVVKRQGFYINDNdK 862  Dictyostelium...
YP_001227736  418 PpleplaELASGL-------PDQr-wQGWLPAWSADQPLHWLRELLRPAEQALGRHFAALELP-GLFLTHGAPDPGQLnD 488  Synechococcus...
YP_001224829  419 PqldmlgDLNPLA-------PDGd-aANWAEPLNPSSPESVMAVLLRTAHRVWHAQSEDLKLP-SVLLGAPPADDSALmD 489  Synechococcus...
YP_001014865  418 PklerlsELSKTF-------PGRd-fHGWSKTYDCCDPQSLIDIYIRLSNNILSKHLIGYRLP-FIYKEHEEIDQSSInE 488  Prochlorococc...
NP_875380     418 PvienleDLDKTV-------PGGe-fNGWSDTYKDKDPQSIISVFTKYANIILKDHFISYNIS-FIALKFKQPDNIQLnD 488  Prochlorococc...
2IX0_A        446 L-AALLKTHGLHVDAEEV----LTldGFCKLRRELDAQPT-G--------FLDSRIRRFQS--FAEIST-EPGP------ 502  Escherichia coli
NP_892965     491 IiKNSELIDSNIELNDNG----TL--SFKKLVELCTDDNK-Kr-------ILHKILFNVVR--DNEVTLiSNDN------ 548  Prochlorococc...
YP_001011237  491 IiKNSELINSDIELNENG----TL--TFKQLVELCSDDDNkKr-------ILHKLLINVLR--DNEVKL-ITKDf----- 549  Prochlorococc...
YP_001484255  491 IiKYSEFIDSDIELNEDG----NV--SFSQIIKLCGDDNK-Kr-------ILHKLLINEFKenQIRLIS-KNPD------ 549  Prochlorococc...
XP_001386742  689 DtSKRQSHPDNAIVSHDNkllpSY--EANSYFQTLLARDE-NgfvsssaaIIGRNFLNKSI--VEVFSG-DSSRn----- 757  Pichia stipit...
XP_637628     863 KtVVFDNDNSVTFNHGNv----DF--KVSKSFHSIGNEIV-DeflsstddVLTDFFKKNGI--HGFYKR-FGQMt----- 927  Dictyostelium...
YP_001227736  489 LvKLAVGLDIPLELGSDGn----A--PAAQALAAAFAGTdr-------srVLQQQLREVTT--PVQLSA-EPGAnala-- 550  Synechococcus...
YP_001224829  490 VaKAAIALDVPLELDEDG-----T--PSADELAKAVAGCqs-------srVLNLQLRHALP--DSLYRL-NEAAatagnp 552  Synechococcus...
YP_001014865  489 LtKSALALDKKITVNVDG-----T--ITSSELIKSFESSse-------kkILHKLVKHIIP--GVHLKL-YEINthedit 551  Prochlorococc...
NP_875380     489 ViKSALVLDTKINVNEEG-----I--ISFKDLILSLKESpn-------krLIEKIISNTIL--DKYYSI-PTSNsddlg- 550  Prochlorococc...
2IX0_A        503 ----------------------------HFG-LGLEAYATWTSPIRKYGDMINHRLLKAVIKG 536  Escherichia coli
NP_892965     549 ----------------------------TID-DSKNIISPWTLPSFDFTNLMNQYNIYNMIIN 582  Prochlorococcus marinus subsp....
YP_001011237  550 ----------------------------NKI-DSKKIISPWTLPSYDFINLINQYNIYNMIIN 583  Prochlorococcus marinus str. M...
YP_001484255  550 ----------------------------NDE-SEKLFISPWTIPGFDLTNLINQYCIYNMIIN 583  Prochlorococcus marinus str. M...
XP_001386742  758 ---------------------------vAKG--LSKGYVDIINVTNNFGSMLNQMQLLSHIQL 791  Pichia stipitis CBS 6054
XP_637628     928 ----------------------------YQRiSNTNTFIAATSPLRNFPHLFNQIQLTSILIK 962  Dictyostelium discoideum AX4
YP_001227736  551 -------------------------aeeT-------AYAPWCCPSLHYSAIWNQLLLVALLSE 581  Synechococcus sp. RCC307
YP_001224829  553 qpdadnttdpdsetttsddvdeqtsraeSPGsVGAQSLAPWCCPTLHYADLLNQQVLCQLLNE 615  Synechococcus sp. WH 7803
YP_001014865  552 -----------------------hlnhdAA---QTNIESPWCCPSLNYWNIFNQFILSLLLSE 588  Prochlorococcus marinus str. N...
NP_875380     551 -----------------------lskedSTNlISADIEAPWSSPGMNYADVINQFILLKLLNE 590  Prochlorococcus marinus subsp....
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