Conserved Protein Domain Family
SMC_Nse1

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pfam07574: SMC_Nse1 
Nse1 non-SMC component of SMC5-6 complex
S. cerevisiae Nse1 forms part of a complex with SMC5-SMC6. This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism. It is conserved in eukaryotes from yeast to human. This domain lies immediately up-stream of the DNA-binding zinc-finger domain, zf-RING-like pfam08746.
Statistics
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PSSM-Id: 462214
Aligned: 80 rows
Threshold Bit Score: 141.979
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003688301  22 RYLLQYLLfCQGICNESFMLLALMRLHltdgsssddfyrlnMVELNAELDAIIDLVNVKLDKLKFKICKVSHPLGkdevs 101
XP_003062341  12 HVFLQAMM-SRCVMSETDARAMYAEIVga----------dvARADARGFDRFWGEIASQLGYLDLDLRRVKYQDD----- 75 
EFN55351      36 HCFLQAIM-GRQYLKESDAKELYRQITga--------------aHDGNYLHFMADINQQLNFAQFELRRVKYPGD----- 95 
CBI24358       9 HALIQALL-SRGPLIEDDFHAIFSGVTgk-----------nPGAHQQQFNDYLLKINKELSYVHLELRGCRNQYD----- 71 
ACF88202       9 HTLLQSLL-HRGPLSERDFHAIFAGVSgk-----------nPATHQQLFNDTLLKINKDLAYLQFELRACINQYD----- 71 
XP_006663780   9 HTLLQALL-SRGPLSERDFHALFTAISgg----------knPATHQQLFNDTLLKINKELSYLQFELRACIHQYD----- 72 
XP_003578992   9 HTLLQALL-SRGPLPEPDFHALFTDMTgg----------knPATHKQLFVDTLGKINNELKYLNFDLRAGINQYD----- 72 
XP_020157732   9 HTLLQALL-SRGPLSERDFHALFTAISgg----------knPATHQQLFSDTLMKINNELGYLQFDLRACINQYD----- 72 
XP_006354180   9 HTLIQALL-SRGPLKEKDFQSIFTKITgk-----------sPGNHQSLFNEYLRKINGELAFVQLELRACRNQYD----- 71 
EEF40760       9 HTLIQSLM-SRGPLKEDDFHKIFSSVTgk-----------nPRTCGREFNDFLLKINKELSYVQMELRRCRNQND----- 71 
XP_003688301 102 sytkddieklllainddsdedtlskdvilefasqvqaSNKyYVYVNLESDKETELATTYTVKE--------IECMKRLIK 173
XP_003062341  76 -------------------------------------DELyLGIVNKVASDSAKLATTMTPEQ--------IALFRVVLD 110
EFN55351      96 -------------------------------------GEWyLGFVNREGDEPSKRATKYRGAKdgkpdtriTAYFRALLD 138
CBI24358      72 -------------------------------------GKVyYGVVNNVSDEQSKLGTKYTVPQ--------LAFYKGIIE 106
ACF88202      72 -------------------------------------GMVyYGVVNNIADEESKLGTKYSVPQ--------IAFYKGLLE 106
XP_006663780  73 -------------------------------------GTVyYGVVNNIADEESKLGSKYSVPQ--------IAFYKGLLE 107
XP_003578992  73 -------------------------------------GTVyYGVINTIADEESKLGSKYSVPQ--------IAFYKGLLE 107
XP_020157732  73 -------------------------------------GTVyYGVVNNISDEESKLGSKYSVPQ--------IAFYKGLLE 107
XP_006354180  72 -------------------------------------GHVhYGVVNNVSDESSKLGTKYSVPQ--------IAFYKGIIE 106
EEF40760      72 -------------------------------------GQLfYGLVNNVSDDQSKLGSKYSVPQ--------ITLFKAAIE 106
XP_003688301 174 MMVNNsTRPREV-----DTTVRANPvfKEIKNmlsRYerdrggdteeevnvpmwtsyisyqigSTEAAsn---------- 238
XP_003062341 111 EILRE-DATCDAknggvDVISALNAtqIWTGAtqgAT--------------------------QGGEGgatqltqaqtes 163
EFN55351     139 QMVA--SSAADQg---lGYLTSQQAlyIQISPda----------------------------aTQAEEeeaaavrqqade 185
CBI24358     107 AIVQDvTa--------qGSISDIDAlnIRLENqvlTG-----------------------------TShsqgippnvpaa 149
ACF88202     107 AIVQEaGn--------dGSITSIDAlnVRLDNqvaVL----------------------------DGSqdsqsrl--pss 148
XP_006663780 108 AIVHEaGn--------dGSITNIDAlnTRIDNqvvIA----------------------------DGSqshdsqsrlpts 151
XP_003578992 108 AIVQEaGn--------dGTITTIDAfnVRIDNqviIA----------------------------DSTqdsqsrl--pss 149
XP_020157732 108 AIVHEaGn--------dGSITSIEAlhVRIDNqvvIA----------------------------DGTqdtqsrl--pss 149
XP_006354180 107 AIVQDaAa--------qGFISTIDAlnIRLENqflAG----------------------------TESqtqggsthipaa 150
EEF40760     107 AIVQDaTa--------qGSISWSGAlnIRLENqvyNS----------------------------AESqsqgsssqvppa 150
XP_003688301 239 -mvMTSTETQVFLNTLCADKWFYRTRN--GRYGLDLKGAFE 276
XP_003062341 164 vakMSKTEKEATLKRLCEEGWLRRGDDeaGKLTIGVRSFLE 204
EFN55351     186 vrkLSMKERETVLAQLATDGWLAHMPSraGCYTLGPRSFLE 226
CBI24358     150 fknFSISQKEKTLDELVQDQWLSSTPD--GKIRLGVRSFLD 188
ACF88202     149 iknFSMSQKEKTLDELIRDRWLSYTAT--GKIGLGTRSFLD 187
XP_006663780 152 itnFSLSQKEKTLNELIQDHWLSYTPT--GKIGLGIRSFLD 190
XP_003578992 150 itnFSFNQKEKTLDDLIQDRWLSYTSP--GNIGLGIRSFLD 188
XP_020157732 150 itnFLFSQKEKTLTELIQDRWLAYTSE--GKIGLGIRSFLD 188
XP_006354180 151 frnFSMSQKERTLEELARDHWLSLT-D--GKVGLGVRSFLD 188
EEF40760     151 lrnFSLSQKEKTLDELVCDKWLCRTPD--GGIGLGVRSYLD 189
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