Conserved Protein Domain Family
DUF4354
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pfam14263: DUF4354 
Domain of unknown function (DUF4354)
Several members of this family are annotated as being ATP/GTP-binding site motif A (P-loop) proteins, but this could not be confirmed. The one PDB:3NRF structure solved for this family exhibits an immunoglobin-like beta-sandwich fold. Crystal packing suggests that a tetramer is a significant oligomerization state, and a disulfide bridge is formed between Cys 125 at the C-terminal end of the monomer, and Cys 69.
Links
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Statistics
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PSSM-Id: 433820
Aligned: 5 rows
Threshold Bit Score: 156.157
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ACQ67907                1 MRKkifiASILLAGCCLTAA---AKTVDKIIVFSTEKSKGALSIGRQQTYTKTFDIALSNNSQQDIELSTSCLKAFdSNG 77 
TriplettUF:B488_01880   1 MKK----SYLLLYPICFLFSiaaSSVPPEVIVYAKQKETGSIFSPHKFTYTKDFDVTVVNFSQGEIDLSKYCFKAM-LGM 75 
CBJ89203                1 MKVstfvASIALAGFCFVAN---ASTLDRVAVYSTEKSNGSVSVGGKNAYTKSFEVAVANLSDKDIDLSKLCLKAYsPDK 77 
Q11IS2                  1 MKNty-aYSILAMAFVLLSCsekAIVEGPIKVTSTRDALEVETDEPGDQ--KAFKVKVENIGVAPVDLTDGCFVLVgPDK 77  Chelat...
Q9I2H0                  1 MKNa---MALTLAGLLAAPSlgfAAAPDAVMVFARQGDKGSVSVGDKHFRTQAFKVRLVNAAKSEISLKNSCLVAQsAAG 77  Pseudo...

ACQ67907               78 KEFKLDTVDEKLIPNKLKKGELVKGIAMFVSDDASVYGANIVRL-VK 123
TriplettUF:B488_01880  76 KEFNVDTIDEKLASKKLKNGERLRGVVVFSSNNSDVTQANIVQL-TD 121
CBJ89203               78 KEFRLDTVDEDLNQGTLKAGKSVRGIAVLASENDVVHKAALIKI-SA 123
Q11IS2                 78 YKIVANT---PVLDRTILPGQILEGSVVFAGPR-SIFSAREVKFsTS 120 Chelativorans sp. BNC1
Q9I2H0                 78 QSFRLDTVDEELTADTLKPGASVEGDAIFASEDDAVYGASLVRL-SD 123 Pseudomonas aeruginosa
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