Conserved Protein Domain Family
7TM_GPCR_Srw

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pfam10324: 7TM_GPCR_Srw 
Serpentine type 7TM GPCR chemoreceptor Srw
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.
Statistics
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PSSM-Id: 402097
Aligned: 85 rows
Threshold Bit Score: 205.132
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9U2P2        37 PFTF---IFSCFGFLINIFHLITITRKSLRANSVYVLMIGITSSDLYTMFHINYVYIDTIISTylhn---kmyeGYKCWy 110 Caenorhabditis ...
Q965Z6        17 VFNYvicILQFFGFGINLIHFSILTRKHMRSNSIYCLMCGICACDLLTQINTFLIFSPFWIREtk--------vGEECY- 87  Caenorhabditis ...
XP_002647399  25 IFNYticIMQFFGFAINLIHISILTRPQMRSNAVYRLMIGICCCDLLTQINTFLIFSPFWIRNls-------kpEDECY- 96 
XP_002647398  27 IFEYvlaILQFFGFFINLVHLSVLTREDLRMNSVYRLMIGICSCDLISHTLTFIGFSPFWIKEvr-------keSQKCF- 98 
O45170        30 KLNFvlaILQFFGFGINLVHFSILSRKHLRTNSVYRLMIGICSCDIISHTLTFLAFSPFWIREvr-------kkNQECF- 101 Caenorhabditis ...
Q9U8C4        39 PFQC---LFALIGLIMNMFHLAIITRKSMRTNSVYVLMIGITISDMFTMFMVVYNNFNDFFK------------FVFCS- 102 Caenorhabditis ...
4_pfamImport   1 KYQC---VFSCSGLLINLVHLIIITRKSLRVNSVYVIMIGITLSDLYTMFHVVYVFLDNIVSNynwyecfqvctEQECFk 77 
XP_045096099  16 KFEF---FAKPFYALLSMFIAFVLST-------------------IMTLLFWSRYELVEVKAWt---------pPVNCI- 63 
Q19558        37 HYEY---YVAWIGAIVNVLHLYILSRKSIRCNSINIFLMGTGICDMFCLCLFIHAYTLTLIFP-----------DDRCW- 101 Caenorhabditis ...
Q19562        37 EIHL---LLACIGAVVNVFHLLILTRKSMSNNSINLMMIGISVCDIFIMSFCVYDILDTLLQK-----------YDECA- 101 Caenorhabditis ...
Q9U2P2       111 i-srVTHGYFHVLCELLMRALGDILRRLSTWLALFMALFRFLIIQFSMNAKFNFVSTPKFALKTIIATFLISFLLTLFAY 189 Caenorhabditis ...
Q965Z6        88 ----MTHTFIDAILYLHGTTVLDITQRGASWMAVFLAFYRTLAIMFPMNGRIQKLSRPVSAVVTIMVVLVFTSLTTWMVQ 163 Caenorhabditis ...
XP_002647399  97 ----MTHTFFDALLYLHGTTVLDITQRGASWMALLMALFRMLSVKFPLNAKIQKISRPVFALWTILAVIIFTSLTTWMVQ 172
XP_002647398  99 ----LTMSYKDAFLSLYPVVVLDITQRTSSWLALAMALYRTLSVMFPMSARMQKMSKPKWAVWTILVLLLVNTSWTLVVF 174
O45170       102 ----LTMTYRDAVLLLYPVIVLDITQRSSSWLAVLMALYRTLSVKYPMSTKMHKVSNPKWALWTIIGVLVVNTAWTLVVF 177 Caenorhabditis ...
Q9U8C4       103 ----FPDPYWKVLLELILAAIQEIVRRVSTWLAFFMALFRWLIIKNTMSGSLGFLSKSSFALKTNIGVLILSTIITSLTY 178 Caenorhabditis ...
4_pfamImport  78 fhkyQYHGYLHVVVELIMSALREALRRLSTWLAFCMALFRWLIIRNSMNAKFDFLSRPSFAFKTVLTLLLISPIITFLSF 157
XP_045096099  64 ----GFPPGYTVPRYK--------SSMDDAWLLKPMLSLQIFSVI---DGLIKIIPTLMFPILTVILVRELKKAADSRKK 128
Q19558       102 ----NYHSYINVFIEVWVSSLNDVLRRASAWLSVMMALTRFLIMKNSLNPKYQFLSKPKFALISMFLAFWVSLLVSVFYL 177 Caenorhabditis ...
Q19562       102 ----PPQSYFSKIFDFWASALEDHSRRLSAWYGVMMALMRFLIVKFALNPKYDALSKPLFSYLSMFIAFLVSTGMTLFFW 177 Caenorhabditis ...
Q9U2P2       190 iGQYRVvEDGLQASLY--CEep-lDFEVPHTYIVGNSRIFDDYWPVVVKYSLMSEGITKIIPAVTLPFLTIGLIKCLHEA 266 Caenorhabditis ...
Q965Z6       164 -ARRIIrPYDWDYD----CDgn-eIPLPETRYGVLVPNEFAAIQSKLVSVYGFi----KALPSLIDPILTILLIIELRKA 233 Caenorhabditis ...
XP_002647399 173 -ARRIIrDYDWDYD----CDkn-eIHLNQTRYGVLIPEEYIDIQARLVSIYGFi----KALPSLIDPILTVFLVLELRKA 242
XP_002647398 175 -GRHAIvERNIDTD----CDgn-eVHLNPVRYLILVQTNLEHLHSTITYIYGFi----KALPSLIDPILTVLLIIELRKA 244
O45170       178 -GRHKIdGRNIDYD----CDgn-eVHLSQLRFMVLVDTSLEHLHSIITSIYGIi----KALPSLIDPILTVLLIIELRKA 247 Caenorhabditis ...
Q9U8C4       179 -SQKEVkDVGFEVIST--CWflekNYKIAHTYSVGRSEFMDKNLNFVEEYAFMSDGIPKMIAAFFLPILAIALVRRLRQA 255 Caenorhabditis ...
4_pfamImport 158 -GQHTVtDNGFVDVs--qCSgi-pDYIVPHTYIIKKGRVFDDFWPLAVQLYFFSDGISKIIPAVCLPFLCIVLVTCLRTA 233
XP_045096099 129 -ASVGSeKHEENSK----------SH-QATKLVILMTITYMAAEGPLGIIYVV-QGFI--IPTLMFPILTVILVRELKKA 193
Q19558       178 -IRVTItEVE-PWTPAdyCAdy-lATYSEKQYSSSVTKYFEANIVAAVQIFLVMDGLSKTIPAAILPTLTVLLIRELKVA 254 Caenorhabditis ...
Q19562       178 -GRYEFtAKE-VWTPPkeCTqy-pLGFTLPLYKSSLDDIYLIDASVALIVFSIIDGLLKIIPALMFPVITFLLIKELRTA 254 Caenorhabditis ...
Q9U2P2       267 SRARQKLNs--pHKN--A--SNDKSVKMVAIMTIFSMIAESPSGIIHTYQFFYYDYSsiITCVKSLDKLFINLSILNAIV 340 Caenorhabditis ...
Q965Z6       234 AKRRKNRG----KSAc-D--KKDSTTKLVIFVTISFFFLEVPNGFSHVVNGFSYGNVplRTLSVMIPVFAEILPVMNSSS 306 Caenorhabditis ...
XP_002647399 243 SRRRKNCG----KSLtvD--KTDNTTKLVAFVTISFFLLEVPNGFSHIVNGLFQDNVpvRTISVMIPVFAECLPIINSSS 316
XP_002647398 245 AKRSKKCG----KPS-----NSENTTKLILFVTISFFILEVPNGFAHVTAGVFHGVPeiLSVSYMVQVFAEILPVFNSSS 315
O45170       248 SKRRKNIG----KEDc-G--KSDNTTKLVLFVTISFFILEVPNGFAHVTAGAFHGNPgiLTISYMIQVFAEILPVFNSSS 320 Caenorhabditis ...
Q9U8C4       256 AESRKHLSn--sKPL-----QTDKSIRMVTFMTLFSVFAEGPMGIFSFIRSFYLRFSsiEASVESLDKMLINLVIVNVIA 328 Caenorhabditis ...
4_pfamImport 234 RESRKNLS----KSSs----NNDRTIYMVTIMTAFSVFAEGPSGISYLFKALYYDHNaiKSALQTLDEILINAAILNSIV 305
XP_045096099 194 ADSRKKASvgseKHE--EnsKSHQATKLVILMTITYMAAEGPLGIIYVVQGFVTQPPgiVEMTMDLIDIFGVFVSINAIM 271
Q19558       255 SDSKRKISv--aMRKgnensKTDHTTKMVILMTICFMSAEGPMGICTVVQGFVVEKSgyLGITFDLVVIFGLFVTINAIS 332 Caenorhabditis ...
Q19562       255 ESIRRKTSq--gSFKkd-saASEQTTKLVILMAITFIAAELPIGAIYVAQGVLINQPviVEITYELVDVLGIFVAINATT 331 Caenorhabditis ...
Q9U2P2       341 HCVISFRVSTQYREVAKKLFSFK 363 Caenorhabditis elegans
Q965Z6       307 HFFICLLMSTQYRETVISIFERH 329 Caenorhabditis elegans
XP_002647399 317 HFFVCLLMSTQYRETARTVFKCF 339
XP_002647398 316 HFFICYFMSSQYKSTVKEVYGRF 338
O45170       321 HIFICLAMSSQYRETSCEIFCGE 343 Caenorhabditis elegans
Q9U8C4       329 HCFISMQMSSQYRDIATQLFLRK 351 Caenorhabditis elegans
4_pfamImport 306 HVIISLVVSTQYRETAKKLFGCK 328
XP_045096099 272 HCVIYLTVSSQYQKSAKSLFCCV 294
Q19558       333 HCLICLAVSTQYRKCAKKVFCWD 355 Caenorhabditis elegans
Q19562       332 HCLICLGVSSQYRRTVKALFKFC 354 Caenorhabditis elegans
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