Conserved Protein Domain Family
7TM_GPCR_Srsx
?
pfam10320: 7TM_GPCR_Srsx 
Serpentine type 7TM GPCR chemoreceptor Srsx
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Links
?
Statistics
?
PSSM-Id: 255903
Aligned: 23 rows
Threshold Bit Score: 232.099
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q9XVI7    14 MVLGIFGNVNVIVAVARKKVLRTKGAMLIFVLAISHLVINIAELKTLI-FRLrFQSLNGRECFLYNIPYSLAIMFQSWLF 92  Caenorhabditis elegans
O01473    19 CCIGLFGNINLIVATCRYKSLRTKLGCLIMISTISHTICLVSELISVK-LKLrFTQTHRDECFRFVVVYMFAVLFQSTLF 97  Caenorhabditis elegans
Q9U1X1    20 SIIGLIGNMTIVLATVISKRLQSRCNILIGLLALSDVVVCTYLIHLRVlMFLdMYMLTSTQCFLLSAYGLFALNMQSSLC 99  Caenorhabditis elegans
Q18767    20 IPVGIFSNVIMIICFFVNPRLRSPFHILLTLTCLADGIHVCGQIIFVF-QMLtNTYSYQSTCYMLNVLPVIGLTLAAPLL 98  Caenorhabditis elegans
Q6BES9    19 AIVGVVGNGIMILVFLKESKFKLPVNYLITLNCLADLFHVSGHFVFNY-QLFnDDKSSQAACFFMMIHTVIGYCISGPLL 97  Caenorhabditis elegans
CAP39830  19 AVVGIIGNGIMVMVFMKESKFKLPVNYLITLNCLADLFHVSGHFVFNY-QLVtDETSSQANCFFMLFHTVIGYCISGPLL 97 
Q19607    20 SIVSCTGNSIMIILFIKEKNFHSPCHYMITFSCLADMLHLCGHFVFNY-HIFaDVTDTQANCYWMLFFTSIGKTMSNPLI 98  Caenorhabditis elegans
Q7JLH4    19 ALVSMAGNIVMVVCFLKERKFNSPCHYLITLTCIADMLHLCGHFVFNF-QLFyQGPGSQELCFWLLLPSTIGLLMSGPLL 97  Caenorhabditis elegans
Q18770    20 SVIGIAGNFVMLLCSFRTKRFRSPCYILITVTCVADAIHISGQFPFCV-HLFgNLTSTQAQCFYMLTVPLIGLTSGGPLI 98  Caenorhabditis elegans
Q18766    20 SVIGVIGNVIMVICTIRTKRFRSPCHLLICATCIADLLHVCGQFPFCV-HLFgNLTSSQAQCFYILTIPIVGFTTGGPLI 98  Caenorhabditis elegans

Q9XVI7    93 LSMALDLCFCIMIPIKHMLWPKTK--YILIMCIMPTCCALIVFFVNFIFVTEE--DAPYCAYMLTMDDGVF---EIISTS 165 Caenorhabditis elegans
O01473    98 LMMAIDLLLAVIMPIRHKLWQRGP--YLLILCTPPVIFSTFAIFIEQLYINHE--NLLMCTVSLAAPRKVRfwgTIITFS 173 Caenorhabditis elegans
Q9U1X1   100 LIIGLDRLYNVTYPLRYSQLPNS---FYIALFLFCVGFSVLITYSGYSYASDSe-IVLVCLPPTAYTDKSR---IIWIGS 172 Caenorhabditis elegans
Q18767    99 MQIGLDRLLAVSFPIRYRELQFQKlfYTSIHLIFPILYTISILYLGFLERNNE---QVKCAIPTALAGISF---KVFTLS 172 Caenorhabditis elegans
Q6BES9    98 LAIGIDRIIACRFPITYRLLLSYGsvYLGIQLIFPITFTSALMIYGYQFIDYN--TQIICMAPLALPRQAF---GYFTYS 172 Caenorhabditis elegans
CAP39830  98 LAIGFDRLIACRFPINYRTLLSNGtlYLCAQLLFPVAFTTVLIGYGSQLIDFN--TQIVCMAPLALPRQAF---GYFTYA 172
Q19607    99 LMTGIDRLIACKSPVLYRALLERPnlYVCGQLILPTAYSSFLMVSGFLQRDTV--TQIYCAVPAAFAGTAF---SKFNTS 173 Caenorhabditis elegans
Q7JLH4    98 LSMGIDRLIACQLPVFYRQLCSRPsfYLCIQLSFPIIYTSYITVISFLQRDSE--TMVICQVPLAMSGNSF---ELFNQG 172 Caenorhabditis elegans
Q18770    99 LSMGIDRLIAVKFPTRYRYIQDEPtlYICAQLMFPISYAGIFLLYGFLVRDTNfkNQIICANPLALNGTAF---QMFTYS 175 Caenorhabditis elegans
Q18766    99 LSMGIDRFIAVKFPTKYRYYQEEPkfYVLGQLAFPLLYSVFFLVYGFIVRDTNvkNQLVCSNPLSLNGSSF---QMFTYS 175 Caenorhabditis elegans

Q9XVI7   166 VVACNILTLLITIVSVFV-----AIRKSQDmrnhrhssvtrrnsTVEERRKVFRSTFYMMSIYIFCWMTSSICFRVLFYM 240 Caenorhabditis elegans
O01473   174 TVLLAVALILVTAVKVHI-------NEQSSsspfirhsststktSRSSEVKLLKSLATLIFFFICSWTMSVILFHVAMYF 246 Caenorhabditis elegans
Q9U1X1   173 NFIIAILVIFVYGGAQIRcrilrARHVHEQ--------------SMDAVNRLLKSLSIVVTIYVCTWFLTISSLVVSQLI 238 Caenorhabditis elegans
Q18767   173 SHAIYVSIILAYLMTAIL-----LKFHDT----------------SSRFKAVFKSIGVTVGIVLFGWAITTVSNTFGLFV 231 Caenorhabditis elegans
Q6BES9   173 SNIINVKIVIVYAYTYFV-----LRGYKER--------------DANRMRYVFKSIALTVIVVLIGWTTVTIGNTIALGV 233 Caenorhabditis elegans
CAP39830 173 SNVINVAIVIVYIYSYVV-----LRGYKER--------------DARRMKYVFKSISFTVVIVLVGWTTVTIGNTVAIGL 233
Q19607   174 GIFINIAIVIVYFFTFLQ-----LRTYAG----------------ATQMKVVFRSILWTVIFVIIGWSSVTIANQFAI-F 231 Caenorhabditis elegans
Q7JLH4   173 GLLINVAVVLIYFTTYIK-----LKKVTA---------------NASQLKTVFKSILYTVIFVILGWCTVTVVNIGCIHL 232 Caenorhabditis elegans
Q18770   176 SGIIYVAVFIVYLSVYIL-----LKSNKA----------------SARFKSVFRSLAVTVGLVMFGWVSTTTANTLSYSI 234 Caenorhabditis elegans
Q18766   176 SAVIYVAVVLVYSAVYLM-----LKSNKA----------------SARFKNVFRSILVTVGFVLLGWVTTTTANTLAFVV 234 Caenorhabditis elegans

Q9XVI7   241 FENETNIVPYMPYLAIITMPNFCQAYFVTYFRSPRFRKAYREHF 284 Caenorhabditis elegans
O01473   247 DSSIGYQ--FHKYTFILQLPTFCQNFFVTALRSPRYARVYREQL 288 Caenorhabditis elegans
Q9U1X1   239 TFSPPVTAEINRQLGWLVIINASLNFFVYLWRNSEYRKAFIRLY 282 Caenorhabditis elegans
Q18767   232 TDDMEVYNLIQMYSGITVNIAISSNLIIFYTINPEYQLTVKMLM 275 Caenorhabditis elegans
Q6BES9   234 IEDRHTSEIISIHAGFGVNISCSINVIVFYAINSEYRSAIRRLF 277 Caenorhabditis elegans
CAP39830 234 IENQRISEIVSIHAGLGVNISCSVNVFVFYAINSEYRSGIRRLF 277
Q19607   232 AKDAATRKLISIYAGIGVNLACASNIFVFYAINTEYRNAIRRLF 275 Caenorhabditis elegans
Q7JLH4   233 VENIENQHIISIYAGIGLNLACVSNVFVFYTINSEYRSAIRKLI 276 Caenorhabditis elegans
Q18770   235 SDSPYTAQLIQMYAGITVNAAAASNVFVFYGINSEYREVIKSLF 278 Caenorhabditis elegans
Q18766   235 TSDLFTIQLIQMYAGITVNFAAASNVFVFYAINSEYRSVIKTMF 278 Caenorhabditis elegans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap