4JET,6JLG


Conserved Protein Domain Family
HasA
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pfam06438: HasA 
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Heme-binding protein A (HasA)
Free iron is limited in vertebrate hosts, thus an alternative to siderophores has been developed by pathogenic bacteria to access host iron bound in protein complexes. HasA is a secreted hemophore that has the ability to obtain iron from hemoglobin. Once bound to HasA, the heme is shuttled to the receptor HasR, which releases the heme into the bacterium.
Links
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Statistics
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PSSM-Id: 428943
Aligned: 3 rows
Threshold Bit Score: 244.481
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4JET_B   1 MSTTIQYNSNYADYSISSYLREWANNFGDIDQAPAET----KDRGSFSGSSTLFSGTQYAIGSSHSNPEGMIAEGDLKYS 76  Yersinia pestis
Q6D6Z2   1 MSFAITYDAYYANYSIANYLTEWSAAFGDVNHTTGNTqvggNNTGGFYGGDTFIDGSQYAITSTQNDFSALIAGGDLTYS 80  Pectobacterium atrose...
6JLG_C   1 MSISISYSTTYSGWTVADYLADWSAYFGDVNHRPGQVvd-gSNTGGFNPGP--FDGSQYALKSTASDA-AFIAGGDLHYT 76  Pseudomonas aeruginosa

4JET_B  77 FM--PQHTFHGQIDTLQFGKDLATNAGGpSAGKHLEKIDITFNELDLSGEFdsgKSMTENHQGDMHKSVRGLMKGNPDPM 154 Yersinia pestis
Q6D6Z2  81 LFspPAHTLYGDLDSLSFGNVLQGGTTA-GTTYSLVEPEVTFSGLDLSTDV---ANLTVSDRGVVHDVIYGLMGGQVQPL 156 Pectobacterium atrose...
6JLG_C  77 LFsnPSHTLWGKLDSIALGDTLTGGASS--GGYALDSQEVSFSNLGLD------SPIAQGRDGTVHKVVYGLMSGDSSAL 148 Pseudomonas aeruginosa

4JET_B 155 LEVMKA--KGIN----VDTAFKDLSIASq-yPDSGYMSDAPM-VDTV 193 Yersinia pestis
Q6D6Z2 157 LDALTN--AGID----INASLDSLSFAT---ATSDAALSADTvVDVV 194 Pectobacterium atrosepticum
6JLG_C 149 QGQIDAllKAVDpslsINSTFDQLAAAGvahATPAA----------- 184 Pseudomonas aeruginosa
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