Conserved Protein Domain Family
AdhE

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COG1012: AdhE 
Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase [Lipid transport and metabolism]
Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase is part of the Pathway/BioSystem: Proline degradation
Statistics
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PSSM-Id: 440636
Aligned: 678 rows
Threshold Bit Score: 165.299
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013952976   1 MShlfferhqalleqatqaiaergywspftE--MPSpRVYGEta-nAdGkaafEaRLnrpfalsqpgtvgqagKEVSPY- 76 
WP_011157452   1 MTa---------------------------I--LQS-LACDRwetpA-T----G-LV----------------DIPSAId 28 
WP_012784184   1 Mq----------------------------T--LGS-FVEDSwwfsT-D----P-GQ----------------PVLDATt 27 
WP_117396484   1 MTl--------------------------mQ--LES-FAAGQwvapS-G----K-VR----------------KIYSAVt 29 
WP_068616331   1 M-----------------------------K--LGC-YAENQwvtgS-D----D-GV----------------LLRSAVd 26 
WP_053235350   1 Mi----------------------------T--LKS-YLRGEwvagT-G----R-AT----------------TLVNPTt 27 
WP_062406024   1 MT----------------------------TalLPN-FFAGRwqtgT-G----A-GT----------------PLFDPVl 29 
WP_050430651   1 M-----------------------------SeiLKN-YVGGEwiagR-G----D-GT----------------PLRDPVt 28 
WP_011237391   1 M-----------------------------K--LAN-YVYGQwlegA-G----D-GI----------------ALQDPVt 26 
WP_013870245   1 Me----------------------------K--IKH-YVQGSwttgK-E----E-GT----------------PILDAVt 27 
WP_013952976  77 GAELGiTYPK--PDLDQLFAGVAEGM-PAWRKAGPEAWVGVSLEILQRLNRRSFEIAYAVMHTTGQAfmMAfQAGGpHAq 153
WP_011157452  29 GRVVA-RASSagLDFAAIARHARQVGgPKLRAMTFHQRADMLKALGAYLGERKEQLYAL-AADTGAN--RR-DNAI-DI- 101
WP_012784184  28 GEEVA-RLATrgLPTEAMVRFARDVGgPALRALGFQDRGALLGALGAYLSEHVDTLHDA-SAVAGAT--AR-DAWF-DV- 100
WP_117396484  30 GEEIA-EAGSdkLDFQQMIDFAKQKGgPALRKMTFHDRARMLKALATYLNERRDPLYEL-AYKTGAT--LA-DSKI-DI- 102
WP_068616331  27 GEPIA-SASSagLDFGAMLQYARQKGgPALRAMTFHQRALMLKALALHLNECKKELYAL-STQTGAT--KS-DSWI-DI- 99 
WP_053235350  28 EEPIA-EASTqgLDLGAALEFARTKGgPALRAATFAQRGAWLDAISKALHARRDALLDESIASCGTT--RS-DAKF-DV- 101
WP_062406024  30 GTELA-RVSSsgIDLAEGFAFAREQGgAALRTLSYGQRAALLSQITEVLQANRVAYYEIATANSGTV--AK-DSGV-DI- 103
WP_050430651  29 GEELA-RVSSegLDLDKAFDFARTKGgTALRDRTYAERAALLGDVAKALQAKRDDYYAISIANSGTT--KA-DSGM-DI- 102
WP_011237391  27 GEELV-RVSSegIDTGRALEFARQSGgPALRALGYEGRAALLGAIVEVLSAKRAEYFDIALRNSGST--EA-DAAF-DV- 100
WP_013870245  28 GEAFT-SVAIegLDVPEILNYGRTKGgEVLRKMTFQERGNMLKKLALYLTKRKDAFYDL-SYRTGAT--KV-DSWI-DI- 100
WP_013952976 154 DRGLEAVAYAWDEMRR-IPkqaiwekpqGKNe--Pl-rM-EKRYSVVPR-GVGLVIGCCTFPTWNGYPGLFASLATGNAV 227
WP_011157452 102 DGSLVTLAAFASRGRReLPdagf--iteGEVealSkrgSfVGQHILTPLhGVAVHINAFNFPCWGLLEKLAPALLAGVPV 179
WP_012784184 101 EGGIGVLYSYASLAKRsLPegnv--lrdGEVerlDrggRfAGRHIFVPRrGVEVQINAFNFPVWGPLEKLAPALLAGMPT 178
WP_117396484 103 DGGIGTVFVYASKGRReMPdahi--ypdGDLeilSrngTfLGQHYCTPLlGVAVHINAFNFPVWGMLEKLAPTLLAGVPA 180
WP_068616331 100 DGGIATMFVYSSKGRReLPndhv--lvdGPAeviSrqgTfTGQHIFVPRrGVAVQINAFNFPCWGMLEKLAPTLLAGMPV 177
WP_053235350 102 DGAIGTLAYYAGLGKK-LGettt---ilePAeqlTksaRfFGAHVWTPReGVAVHVNAFNFPAWGLGEKLAVALLAGVPV 177
WP_062406024 104 DGAIFTLGYYAKQGAA-LGdatl--lldGQRirmAkdpAfQTQHIQVPTrGVALFINAFNFPSWGLWEKAAPALLSGVPV 180
WP_050430651 103 EGAIFTLSYYAKLGAS-LGdakv--lldGDVtslSkdgSfRAQHILTPTrGLALFINAFNFPAWGLWEKAAPALLSGVPV 179
WP_011237391 101 DGAIFTLKSYARAGKA-LGparh--lkeGARvalAktdAfQGQHFLMPLtGVAVFINAFNFPAWGLWEKAAPALLAGVPV 177
WP_013870245 101 EGGFGNLFANAS-LRKlFPnqpy--hveGDAidlSrggRfMAHHIMVPKkGVAVHINAFNFPVWGMLEKCAVNWMAGVPA 177
WP_013952976 228 VVKPHPGAILPLAITVEVArevlQEAG-FDPNLVTLVANDpTERMastLALRPEVRLIDFTGSSANGDWLERNAh----q 302
WP_011157452 180 IAKPATATAYVAEALVKMI----DESKlLPQGALQLVCGG-LGDL---LDHLNGQDVIAFTGSLETSEKLRAHPnvarhs 251
WP_012784184 179 IIKPASQTAPVTHRLVQLI----IDSGlLPPGALQLVAGG-AEDL---LDHLGPQDTIAFTGSAATAELLRSHPsvrtrg 250
WP_117396484 181 IVKPATSTSYVTEACVKMM----VESGiLPEGAIQLVMGG-TGDL---LDRLDCQDVVSFTGSAATASYLKSNQniqkng 252
WP_068616331 178 IIKPATSTAYLTELVVRKM----IEANvLPPGAVQLVCGS-VGDL---LDRLDCQDVIAFTGSKGTADYLRKHPnvmeqs 249
WP_053235350 178 ISKPATSTALLAMRVAEAI----VDANvLPPGAFQFVAGS-TGDL---LDKLGPQDVLAFTGSADTGAKLRGGKgpvers 249
WP_062406024 181 IIKPATATAWLTQRMVKDV----VDAGvLPVGALSVICGS-SAGL---MDQLQAFDVVSFTGSAETGQIIRSHRavtels 252
WP_050430651 180 IIKPATATAWLTQRMVADV----IAAGvLPEGALSVVCGS-AAGL---LDRVQAFDVVSFTGSADTAAKLRAHPafvsra 251
WP_011237391 178 LVKPATPTAWLTQRMVEDV----VKAGiLPAGALSIVCGS-ARDL---LDHVGECDVVSFTGSADTAARMRTHPnvvars 249
WP_013870245 178 VVLPAPSSSYLAEAVARTI----IDSGiLPEGALQIINGT-VKNI---LDTVESQDVVTFTGSAQTGRLLKAHPrliqes 249
WP_013952976 303 AQVYTEKAGVNQIVIDSTG-----DFKGMVRNIAFSLALYSGQMCTAPQNIYVPTDgIDtpeghlsfDQVAAAIGEGVVR 377
WP_011157452 252 IRFIAERDSLNAAVLGPDIkpadpEFDLFAHEIVREMTAKAGQKCTAIRRVLVPRA-QE--------AAVIEALKARLAD 322
WP_012784184 251 THLTVETDSLNASILGPDAvpgtnEFDLYVSQLVDELTIKAGQRCTAIRRALVPAS-LV--------GPVVEAATERLSA 321
WP_117396484 253 VRFIAEQDSLNASVLGPDVtpetpEFDLFVKEALREMTAKAGQKCTAIRRMIVPDT-QV--------QNVIDALSAKLAK 323
WP_068616331 250 VRFTAETDSLNCSVLGPDAgagtpEFDLYIDEVVKEMTTKAGQKCTAIRRIIVPEQ-HS--------ADVVRRLSERLAA 320
WP_053235350 250 VRVNVEADSLNSAVLGPDIepgsdVYATFLRDVVREMTQKTGQKCTATRRIFVPAA-VI--------DRVQEDLAEQLGA 320
WP_062406024 253 VRCNIEADSLNSALLSPAAttdseAFKLLVAEVAREMTVKSGQKCTAIRRIFVPRA-LY--------QAAAEAIGARLAK 323
WP_050430651 252 ARLNIEADSLNSALLGLDAspgsgAFDGFISEVAREMTIKSGQKCTAIRRAFVPAA-HF--------DAAAEALRAKLAK 322
WP_011237391 250 VRINIEADSINSAILGPDAqpgtpEFDLAVKEIVREMTIKTGQKCTAIRRVFAPAA-AS--------RSLADAVAAKLAS 320
WP_013870245 250 VPFTMEADSLNASILGEDAvpgtpEFDLFIKEVRKEMTVKAGQKCTAIRRIIVPEK-LV--------DDVETALAKQLDK 320
WP_013952976 378 L-TSDAAKAVELLGAIQNDGVVQRIESSRAL----GE-IVADS-RVlehp---efpGARIRTPLVLKv-Da-SDEGKIMQ 445
WP_011157452 323 VkLGDPRRDDKAMGPLVSRGQREAVRAAIATlq-sEAeIVFGDpNVceaeg-idtqAGAYMSPVLLRarEpmQASHVHAT 400
WP_012784184 322 VtVGDPRRPDVVMGPLASLAQRAEVRARIDEla-rAAdVVVGG-DLddvlg-adpeRGAFVAPTLLVarDa-DRDEPHRI 397
WP_117396484 324 NvIGDPTAEGTRMGALASLDQKKDVLEKAAEig-tECdLVFGDqDNlqlng-egleNGAFVAPMLFHckDpdKATIVHCT 401
WP_068616331 321 IkVGNPANPEMDMGALVSQGQREEVMERIADlq-kDGtIVHGSlDNfavad-gdikKGAYFAPVLLEcaDpmSATTPHSV 398
WP_053235350 321 IkIGDPARDEVRMGPLATKQQHEDFRSGVAKlvasGArVVH-T-Revs------epKGYFVAPTLLRadApaSATAVHAH 392
WP_062406024 324 TtVGNPRSESVRMGALVSQEQKASVLAGLAQlk-tEAtVLFDG-SAaglv--dadaSSACVAPVLLGteSpmTAQVLHGV 399
WP_050430651 323 ItVGNPRNETVRMGSLVSRDQHTSVKAGIDAlr-rETeLLFDG-SAtplvd-adpeVSACVAPHLLGlrDg-EASAVHDV 398
WP_011237391 321 YrVGNPKSEGVRVGPLVSRAQQAAALEGLAKlr-eECeTVFGG-GVdfapvdadpaVSAFVQPTLLYcdKglDARHVHDV 398
WP_013870245 321 VtIGDPRLKEVRMGSLVSHQQVQAVRDSVNDls-kEAqIVYGNlNEintig-adakKGAFISPILLRadNpfQNTVIHER 398
WP_013952976 446 ELFGPISFIVATDNTAHSIALAHRgAKehGALTLSAYTTDAGVNEAIRDaaedagvALslnLTGGVFVNQ------S--- 516
WP_011157452 401 EAFGPVATVLAYDDVAQAVELVRR-GE--GSLVASLFTYDDVVAEQMIL-------GLa-pFHGRLLIVDrddaaeStgh 469
WP_012784184 398 EAFGPVATVLGYQDPQHAAKLAAR-GA--GSLVASVVSADARVVDELVM-------ELa-pWHGRILVLDatsapaStgh 466
WP_117396484 402 EAFGPVATVMGYRDLGHAIELMNK-GG--GSLVASVITHDADVARELTM-------GAa-aWHGRLYFNNrdsmkeStgh 470
WP_068616331 399 EAFGPVATVLPYRDLESAAELVRK-GG--GSLVCSLFTNDNAVARELVL-------DCa-aYHGRIMTINrdcaaeStgh 467
WP_053235350 393 EVFGPCATLMPYAEIAECVKLVAM-GE--GGLVASVYGDDRALLRELVL-------GIa-pWHGRVVIASskvadqSiap 461
WP_062406024 400 EVFGPVSTLMPYDSIGEAYTMIRR-GE--GSLVCSVYSEDPAFTAQASV-------ELa-sSHGRVHAISpdvaalHsgh 468
WP_050430651 399 EVFGPVATLIAYRDEAHAIDLARR-GG--GSLVASVFSDDEGQLAHFAV-------ALa-dTHGRVHAVSpavaktQtgh 467
WP_011237391 399 EVFGPVATIVPYADTAEAIALARR-GR--GSLVASVYSGDAAFLAELVP-------GIa-dLHGRVMVVDaavganHtgh 467
WP_013870245 399 EAFGPVSTIMPYKNLDEAITLAQM-GK--GSLVSSIATNDDKIAKEYVI-------NAa-sHHGRILVLNresakqStgh 467
WP_013952976 517 ------AAFSDFHATGANp-AAN-ASLSDaaFVanRFRVVQS 550
WP_011157452 470 gtplpaLLHGGPGRAGGGeeLGGlRSVYH--YM--QRTAIQC 507
WP_012784184 467 gsplprLLHGGPGRAGGGeeLGGmRAVTR--HL--ARTAVQG 504
WP_117396484 471 gsplphMVHGGPGRAGGGeeLGGvRGVTH--YM--QRTAVQG 508
WP_068616331 468 gsplphLVHGGPGRAGGGeeLGGiRGVLH--YM--QRTALQG 505
WP_053235350 462 gmvlpsCVHGGPGRAGGGeeLGGeRGLRF--YM--QRTSIQA 499
WP_062406024 469 gnvmpmSLHGGPGRAGGGeeLGGlRALNF--YH--RRTAVQG 506
WP_050430651 468 gnvmpqSLHGGPGRAGGGeeLGGlRALNF--YH--RRAAIQA 505
WP_011237391 468 gnvmptCLHGGPGRAGGGeeLGGlRALAT--YH--RRCVVQG 505
WP_013870245 468 gsplpyLVHGGPGRAGGGeeMGGmRGIKH--YL--QRTAIQG 505
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