5FIR


Conserved Protein Domain Family
XRN_N

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pfam03159: XRN_N 
XRN 5'-3' exonuclease N-terminus
This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus.
Statistics
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PSSM-Id: 460832
Aligned: 133 rows
Threshold Bit Score: 124.954
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FIR_C          2 GVPAFFRWLTKKYpatvvnanedrqrdqdgnrvpvdctqpnPNFQ-EFDNLYLDXNGIIHPCThpe-------------- 66   Caenorhabditi...
EGG20252        2 GIDGLNTFIRKEFkvtrewnnnndnnfrggggggqqpqqqqSQQPlRATHLYFDLNNILHVCSr---------------- 65  
EFC46364        2 GVPFLFSFLLSECpemikeii------------psssasssSNTTmTIDHLYLDMNGIIHTFKdtnlqtkllerlvssss 69  
Q555U6          2 TVPGLSGFINSKFqgtc--------------------ikerGNGKiKVDHLFVDVNNLLYRKYky--------------- 46   Dictyostelium...
EGR32559        2 GVPGFYSWLSRRYplivn-------------------qlnsKLDVpYIDCFYLDMNGLIYKCTkeedtv----------- 51  
XP_001027386    2 GVPGFYSWLARRYplilh--------------------qikkGEVpNIDCFYLDMNGIIYKCSkdegtv----------- 50  
A0CLH9          2 GVPNFYSWLSKRYpmcky--------------------pftkHHGhQIDFLYLDMNQVIYKCAtnqti------------ 49   Paramecium te...
A0CZ91          2 GVPNFYSWLMRRFplcl----------------------yehtRAqRVDYFYLDMNQIIYKCAtdptvl----------- 48   Paramecium te...
XP_001610853    1 ----mFYWLLDNFgsfksgl-------------------ekvierrPVDHLYMDMNAVIHVAThgni------------- 44  
Q4UI27         79 GVPRLYGWMMENFsrvri-------------------plddSEISkGVDYFYVDMNAVIHSAThgni------------- 126  Theileria ann...
5FIR_C         67 -----------drpAPKNEDEXFALIFEYIDRIYSIVRPRRLLYXAIDGVAPRAKXNQQRSRRFRASKEXAEK------- 128  Caenorhabditi...
EGG20252       66 --------------KCKSKKLFFKKLHAALRRHLVFFKTTDTIFYAIDGPGPHSKLLEQRKRRWDSALKTVRSnheyvas 131 
EFC46364       70 ssssssssnneeveIPMTMEKFIFSILLYLEEVIYRFRPSKTLMFALDGSAPCAKINQQRERRWVSFNNHSGLpkrhhhh 149 
Q555U6         47 -------------sKTKPDRTLFDIVNLQIYSLFDKVDVEKSIFFAVDGPGPISKFSEQKDRRFKNDALPNFLhklntkk 113  Dictyostelium...
EGR32559       52 ---------fkdllLQKNMQEIFTLIFNYIDEMVNLVQPKKVLYLFLDGPAPRAKQNQQRTRRFLSAKSHKDLnnslknc 122 
XP_001027386   51 ---------fkdllLQRNIQEIFSMIFNYIDEMVNLVEPKKVLYLFLDGPCPRAKQNQQRTRRFQSAQSWKDLndslrnc 121 
A0CLH9         50 ---------lkdymIEKSIESLWTSILNYIDTIINLVDPQLVIYLTFDGVAPRAKANQQRQRRFASSKGDAKIkqllkql 120  Paramecium te...
A0CZ91         49 ---------fkdqlRERDFDDIWVSILNYLDMIINLVNPQQLLFLAFDGVAPRAKMNQQRQRRFQSQKRYKYLsahlqqi 119  Paramecium te...
XP_001610853   45 -----------spvVQMANEQRLRRITSAIEMMFDIVRPRKMLYMAVDGVCPTAKINQQRGRRFLTSKNVDPLadicsav 113 
Q4UI27        127 -----------fpiLMMEDQQRMRRIVAALLNTFNLVKPKKMMYIGVDGVCPSAKINQQRTRRFRLYKSSNSDneyykve 195  Theileria ann...
5FIR_C        129 --EA-----S-IEEQRNRLXAEGIAVPpk--------------------------------------------------- 149  Caenorhabditi...
EGG20252      132 ddEDgddedTdHQKGGGEDQDELDEELedfddeddeddlyldedaimpdkadtdalssssddekivyqnndyegrggaat 211 
EFC46364      150 hqHGnhhgeQhDLHHGEENRKKKED------------------------------------------------------- 174 
Q555U6        114 lnLQegdenKsDLQLVEDSWFDQSSIv----------------------------------------------------- 140  Dictyostelium...
EGR32559      123 giLAen-------------------------------------------------------------------------- 128 
XP_001027386  122 gfLSeg-------------------------------------------------------------------------- 127 
A0CLH9        121 dlEQqn-------------------------------------------------------------------------- 126  Paramecium te...
A0CZ91        120 glFQkn-------------------------------------------------------------------------- 125  Paramecium te...
XP_001610853  114 saEDgytyiAkRLPFDEYDNVS---------------------------------------------------------- 135 
Q4UI27        196 dgKMkykvnKlKIGAYDNVS------------------------------------------------------------ 215  Theileria ann...
5FIR_C        150 ----------------------kkEEAHFDSNCITPGTPFXARLADALRYYIHD---RVTndaswA--N-IEIILSDANV 201  Caenorhabditi...
EGG20252      212 ssttttttttsttppsisiplkilAEDDFESVMLTPGSSVMEQLKQELMDFSKE---SIK-----KsfHpRSIVISPANT 283 
EFC46364      175 -------------------------ESLFDSISITSGTSFMKELSEHLQFFIKR---KLQddpnwR--NiENIIFSDSSV 224 
Q555U6        141 ------------------------EDKCYTSDSFTSGTDTMGYVKAILYSITKNfkwKGYf----E--DlENVYISPHDR 190  Dictyostelium...
EGR32559      129 --------------------------qtMQNNAISTGTTFMHELNQQIQFYIKN---KFKqdpqwK--N-LEVFFSGSNV 176 
XP_001027386  128 --------------------------etMKNNSISTGTEFMHDLNKQLHFYICK---KFEqdprwS--N-LEVFFSGSNV 175 
A0CLH9        127 --------------------------htFKNNQITAGTEFMYELNEQVKFFINR---KFKedekyA--N-LQVIFSGSDV 174  Paramecium te...
A0CZ91        126 --------------------------etYKNNQFSPGTEFMTQLNQQIKFYIER---KYSedpkfK--N-LKIIFSGCDV 173  Paramecium te...
XP_001610853  136 ----------------------------FNPNYISPGTDFMKIVDSEISNWLAL---KTEegffgK----CMVTYNGVTV 180 
Q4UI27        216 ----------------------------FNPSYISPGTQFMSMMDSEIRNWIALqnyEGTw-------NdCYIVYNGTDV 260  Theileria ann...
5FIR_C        202 PGEGEHKIXDYVRKQRgnPAHDPNTV---HCLCGADADLIXLGIATHEANFNI 251  Caenorhabditis elegans
EGG20252      284 KGEGEWKIYHHINHHL--DKTNPNQT---VVVFSSDSDLVLYALLSQVRTLLV 331 
EFC46364      225 FGEGEHKIMSHIRKVQ----QIPNRKsekFMIYGMDSDLILLSLVTHEEDIYV 273 
Q555U6        191 YGEGEWKIFEMINSDN----IKPREP---ILIYSSDSDVILFSILAKNKSINI 236  Dictyostelium discoideum AX4
EGR32559      177 PGEGEHKIINFMHQYCssDNYDPSTT---HCIYGVDADLIMLGLSTHIKYVSI 226 
XP_001027386  176 PGEGEHKIINFMHQYCssQDYDPTTT---HCIYGADADLIMLGLSTHIKYVSI 225 
A0CLH9        175 PGEGEHKILEFMRGIKnqQNFNPDWT---HCIYSADADLIMLGLGIHLKYVSI 224  Paramecium tetraurelia
A0CZ91        174 PGEGEHKLLSFIRNLQ----CDPNSV---HMIYGADADLIMLGLLTQLKNVLI 219  Paramecium tetraurelia
XP_001610853  181 PGEGEHKIFQCIRKMN---KVCKRSRkdvHLVYGLDADLMMLSMAVKMPNIKV 230 
Q4UI27        261 PGEGEHKIYDTIRKML---ELDPDVRnstHLVYGLDADLVMLSLITKLPKMYI 310  Theileria annulata
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