Conserved Protein Domain Family
SLC12

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pfam03522: SLC12 
Solute carrier family 12
Statistics
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PSSM-Id: 460955
Aligned: 64 rows
Threshold Bit Score: 382.351
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAP36148      700 RSCLVDFANNITKGSSLLVCGQVVPYDPSDRVHTVIrk------------------lDDVVSIWMRKR--------HLKA 753 
P34261        490 RPGLVDFAHSITRGKSLLICGYIIPKISNKVEQPMTwteylmqqspcsrsyllqlkiDKQINDWLRAR--------EVNA 561  Caenorhabditi...
EFO88059       89 RSCLVDFANNITKGSSLLVCGQVVQYDPSDRIHTVIrk------------------lDEIVAIWMRKR--------HLKA 142 
4_pfamImport    1 RPALLHLVHAFTKNVGLMICGHVHMFPL-----------------------------TKLSLSFLKKRysilrcsnRTSV 51  
EKC27450      617 RPELVDFVYSLTNKISLMVCGNIVEGPQSDNLKHLRgm------------------rPKEAYHWLHNR--------RVKA 670 
XP_009029757  691 RVPLVDFCSSITKNIGLMIAGHVVLTPVQYKLMDLRq-------------------sVQKAHLWLNKQ--------KIKS 743 
XP_009013574  620 RPALVDFCTSMTKNISLMVCGHVIIGDPSQKLKDAQl-------------------lTKLAHMYLTRK--------RSKS 672 
EDO41391      585 RPNLTYIVSQITKNVGLMVCGQVNVGSLCQ---------------------------VKSEKDWLRER--------KIRA 629 
EKC33789      758 RPALIDFASSITKKQSLLITGHVFTGEMSDHVKNLR---------------------SHGAYKWFESR--------KIKA 808 
XP_014340414  563 RPSLIDLAHAFTKNVGLLICGHVHLGPLRQTLK-EMsv------------------nQVRYQRWLIQQ--------KKKA 615  coelacanth
CAP36148      754 FYRAVANSSFRKGAQSLIQLTGIAKMKPNIVL-VGFKSN---WymggpTEQNL--NEMNEYFGTIQDVFDWNMAVCVLRn 827 
P34261        562 FGAAICCTKQAEGANILLQTAGLGRLRPNILM-LGYKTG---W-----EKLSK--ESISEYYGMLSNAFDKQVGVIIFRn 630  Caenorhabditi...
EFO88059      143 FYRAVANSSFRKGAQCLIQLTGIAKMRPNIVL-MGFKSN---WykegpTEANL--NEMNEYFGTIQDVFDWNMAMCVLRn 216 
4_pfamImport   52 WYA----------FYHLLVLKGILQWSLSALVsFGLKYSimpW-----LH-----EYMASFPHCVSVKQDMFIAMLIFL- 110 
EKC27450      671 FYSVTTAPDFRCGVQNLLQNVGIGKLRPNILI-MGFMSR---W-----NDPEVnkNEVDEYVHVVHDAFDLEYGVGILR- 740 
XP_009029757  744 FYSVVAADNLRRGVQAMLQAIGLGKLRPNVML-LGFKSN---W-----NDCSP--EEVQDYFNIINDAFDLHYGVGILR- 811 
XP_009013574  673 FYTAICAPSLRLGVQSLLQSVGVGKLRPNTLI-MGFKSD---W-----LTSDV--KEVEDFCNIIHDAFDLKHSVGVLR- 740 
EDO41391      630 FHTVCSAASLRDGVQSLLQTAGLGKLKPNTLV-IGFKRN---W-----MRAPH--SEVEEYVNIINDAFELNYGVAILR- 697 
EKC33789      809 FYNAVVTPTLRIGTQVLLQALGIGKLRPNTLF-LGYKSN---W-----RKSEP--EDLEDYFNIIEDAFDLKYGVGILR- 876 
XP_014340414  616 FYSGVCSEDFRQGVQYLIQAAGLGRMRPNTLV-AGFKAD---W-----TTCGV--RAVENYVNIIHDAFDFQYGVIIVR- 683  coelacanth
CAP36148      828 GGVGLDFS--EAMRNLNLVESsSKINVPNIENQekvEKSTNGNlspetvhliekdetarteksaddassrlsYRgSFrsm 905 
P34261        631 EASGFDVT--SSIRKN-GAPI--NDDEDLAEYVdsaTPKLADQ------------------------------Gsqk--- 672  Caenorhabditi...
EFO88059      217 GHVGLDFS--EAMRNLNLVEP-NRLNVPNIEE----KNEKEKNsspetv-----------------hliekgDEtARtek 272 
4_pfamImport  111 IQPKLNIFtaTLQQQQ--------------------------Qqqkkqqkmkn---------nvitlstrteCTvLRtsk 155 
EKC27450      741 LKEGLYCE------------------------------------------------------------------------ 748 
XP_009029757  812 LQSGLDFS--NLHKKEGTTNSdSFSKLATPTTAtvgGLGGDDDd----------------------------DDeFDf-- 859 
XP_009013574  741 LAEGLQLK-------------------TVPQQPsqkQQKQRHRkgktsttrhqqqhqlqllqllqqlqppvtTEpCSssq 801 
EDO41391      698 VREEFDID----------------------------------Dld-------------------------dgDDwMEddd 718 
EKC33789      877 IPEGLDIN--KIPDESETNDDdDDDSDREEHYDdsdEEEDENGdktkqhgsshpde---rkvsggsynfreaSKgAVgpi 951 
XP_014340414  684 IKEGLDISt-HEIQG-----T----------------HSQEKShavgkeattetqteddgspeaeksserdpSTpHGhkk 741  coelacanth
CAP36148      906 emFQRINAFYINASISINETYGseenpddd----------------------------dhdhdddDDDVGDSGADDDDER 957 
P34261        673 kdVPRGKLLNTFRKMSMAVNKD--------------------------------------------LESGGRRSTSSSTR 708  Caenorhabditi...
EFO88059      273 sgDDA------SSSISINETYGsdenpddn----------------------------ddddndeDGDESGADDEKAN-- 316 
4_pfamImport  156 qmSLKEKTERKDDQNLTLPLKK---------------------------------------------------------- 177 
EKC27450      749 ---------ETNANESLPVNDSv------------------------------------------HHKADPEDDEEEKRP 777 
XP_009029757  860 -hERKNREESPNKNEKLGLMGI-------------------------------------------------NNNNSNNNN 889 
XP_009013574  802 lrADRNLIKKVTETAGL--------------------------------------------------------------- 818 
EDO41391      719 elYNKSQTSRGKESLSVRMDPDsgssdksrsrnvrifhtpptslkhfpgdertpptslkhvpgdeQTSQVRFSSEPSSTL 798 
EKC33789      952 klKRLNTVEEGTENPAFDPDAP-----------------------------------------------NGNTKGVRPKL 984 
XP_014340414  742 idERESERKSRRSRPLLWKAIE-------------------------------------------NWRPIRAFTAAGQKM 778  coelacanth
CAP36148      958 PNKDDDVELGVMDhQDtekrhfslrrrgsrrhtveqKALLSSI-QRFQRKIKKGVID----------------------V 1014
P34261        709 FQVIDKHSISEPD--Q--------------------KIIMAQM-FRFRKRIPNARID----------------------V 743  Caenorhabditi...
EFO88059      317 ---EEDVELGVIDqEEkrhfslrrr--gsrrhtveqKALLSSI-QRFQRKIKKGTID----------------------V 368 
4_pfamImport  178 --------------------------------------------HSISQKFSENTLDlqllspkvsqcdtenhfttsqiL 213 
EKC27450      778 SSPSSPTMLRRSStSSndsdeaddngndvnvelglgKAIQENFkNRFAKKQKRGTID----------------------V 835 
XP_009029757  890 NNDDDGCENCDATgGV----------------------------RYFRSKQSRGFID----------------------V 919 
XP_009013574  819 --------------------------------------------SRFSHKQK-GFID----------------------V 831 
EDO41391      799 RS------------------------------------------VTFKGKQ-KGTVD----------------------V 813 
EKC33789      985 RTMLSSMSTATLS-------------------------------SRFQ-EVQYGTID----------------------V 1010
XP_014340414  779 A---------EVR-------------------------------SHFQKKQGTGTID----------------------V 796  coelacanth
CAP36148     1015 WWLYDDGGLTLLIPHLLSIPKSYlEGARLRIFTIs--TSSRTMEQEQRGMAALLSKFRIDYSDVYVIADIGKKPRQETMA 1092
P34261        744 FWLREAGGLTMLAPYLLTQAGSFlEGAHIRVFTKtdgKDNKRINEEQKNMAAILRKFHIDSSDLHILPEFSKPPCKQTYD 823  Caenorhabditi...
EFO88059      369 WWLYDDGGLTLLIPHLLSIPKSYlEGARLRIFTIs--TSSRTMEQEQRGMAALLSKFRIDYSDVYVIADIGKKPRQETMN 446 
4_pfamImport  214 WFL---GILILSQRKKKSKKKKW-KECKIRVFIGgkiNRI---DHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKESIA 286 
EKC27450      836 WWLFDDGGLTLLLPYILSTKQYW-RNCPLRVFAAg--TKRGEIDREQRQMATLLSRFRIQCEKMTILSDIGKSPSEESMK 912 
XP_009029757  920 WWLFDDGGLTLLIPYLLSTKKLW-KNCQLRVYIAg--SKATELDREQRQMANLLSKFRIEYSSLVVLPDIGKKPSEQSIT 996 
XP_009013574  832 WWLFDDGGMTLLMPHLMTTKKLW-SHCKLRIYMAg--TKKEALDHDQRHLASLLHKFRIKYSSMHVVMDIGKRPSAGKME 908 
EDO41391      814 WWLFDDGGLTILIPYLLTLHSLW-KGCRLRIFTPg----SSNIKNNEIRMANLLKKFRIDFSSIEVVHGIDKAPSNKSVQ 888 
EKC33789     1011 WWLFDDGGLTLLIPYILSKRKIW-KNCKLRIFCAg--TKKGNQYQDEVRMSSLLTKFRIEYSQLTVIPDMWKKPTLTMYK 1087
XP_014340414  797 WWLFDDGGLTLLIPYLLTTKQQW-KECTIRVFTGgkiNTM---DENKRIMANLLSKFRIDFSDIVIIGDINMKPGKDSVR 872  coelacanth
CAP36148     1093 TWQSVIDPFTAPDGSCPMGM-----------TTKS--ELSAQRDKTYRQLRAGELLQEHSIKADLIVMTLPVPRKGMVSS 1159
P34261        824 EFRAKIDKYKVETSSSGEPVdg--------sFDNN--QIFNLREKTRSFLRASELIREHSSDADLIVCTLPSARPE-IPS 892  Caenorhabditi...
EFO88059      447 TWQTVIDPFIAQDGSCPTGM-----------TTKS--ELSAQRDKTYRQLRAGELLQEHSIKADLIVMTLPVPRKGMVSS 513 
4_pfamImport  287 AFEEMIEPFRLHEDDKEQEVadkmkegepwrITDN--ELELYKTKTYRQIRLNELLKEHSSTANVIVMSLPVARKGAVSS 364 
EKC27450      913 NFDKLLEGWMLDEENGESAEkfp------wkVTEE--QKLFLKDKTKRNVRLRELLMEHSKDAALIVMTLPVPRKNTCPA 984 
XP_009029757  997 DFSKLISKWTINKQLKETEQthp------wkITEA--ELVAQNAKNYRHLRLKELLKQHSSDSKFIVMTLPIPRRGICSF 1068
XP_009013574  909 MFMDMLNDWRLKEGETTEEFpw--------kITDS--ELSTFRNKTYRQLRLRELLEEHSHDATFIAMTLPMPKKGLCST 978 
EDO41391      889 DFRRLP-------------------------IKEEldEGVQLDKRILRQIRIGELLRQHSKDARLIVMTLPVPKPTLMSP 943 
EKC33789     1088 DFESLIHQHRLRPHESPDDYpw--------kISDA--DLLANKQKIYRNIKLKEQLLIHSPEASLIVLTLPVPKREACPA 1157
XP_014340414  873 DFDDLIEPFRLHEEDFDKETvekmrtaepwkITDD--ELEMFREKTQRQIRLNELLQQHSSSANLIVMSLPVARKGAVSN 950  coelacanth
CAP36148     1160 SLYLSWLEVMTRNLPPILLVRGNQQSVLTFYS 1191
P34261        893 PIYLGWIDMLSRQTPPTCLVRGNQVSM----S 920  Caenorhabditis elegans
EFO88059      514 SLYLSWLEVMTQNLPPVLFVRGNQQSVLTFYS 545 
4_pfamImport  365 ALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 396 
EKC27450      985 GLYMAWIETLTKDLPPILLLRGNQSSVLTFYS 1016
XP_009029757 1069 GLYMAWLDTLTSDLPPFLLLRGNQENVLTFYS 1100
XP_009013574  979 GLYMAWLDVLSRSMPPMLLIRGNQENVLTFYS 1010
EDO41391      944 LMYMSWLEVLSADLPPVFLIRGNQTSVLTFYC 975 
EKC33789     1158 ALFMAWLEMISSGMPPLLFLRGNQENVLTYYS 1189
XP_014340414  951 TLYMAWLETLSKDLPPLLLIRGNHQSVLTFYS 982  coelacanth
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