1DBX,1DBU,2DXA,1WDV,2CX5,1VKI,1VJF,2J3L


Conserved Protein Domain Family
YbaK_like
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cd04332: YbaK_like 
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YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze mischarged cysteinyl-tRNA(Pro)'s, thus helping ensure the fidelity of translation. Organisms whose ProRS lacks the INS domain express an INS homolog in trans (e.g. YbaK, ProX, or PrdX).
Links
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Statistics
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PSSM-Id: 239824
Aligned: 494 rows
Threshold Bit Score: 50.2341
Created: 4-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative deacylase active site [active site]
Evidence:
  • Comment:A mutation of the conserved lysine to arginine in Haemophilus influenzae YbaK abolishes activity.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     #                                                 
1DBX_A       16 ILHTYDHDpnnqhfGDEAAEKLGIDpNRSFKTLLVAEngd--qkkLACFVLATANXLNLKKAAKSIGvkkVEXADKDAAq 93  Haemophilus infl...
YP_535458   250 KDLEKVATpna-ktIVEVAEFLGTDtQNEIKTLLFIAdd-----ePVVVLMRGIDEVNEVKLKNHLGaidLRPAEEEEAv 323 Lactobacillus sa...
YP_804385   250 EELTKVATdda-hsIDEVAAKLDVDsNRLIKTMVLIVde-----aPVLALLRGNDQLNEVKLTNLLHadeVREATEEEAf 323 Pediococcus pent...
ZP_01274506 249 APIEKKATpga-htVDEAAESLDLDpNQVIKSMLYIAkmsedeyqPVLVLMRGDDEVNEAKVTNAIDceeLELATEEDAe 327 Lactobacillus re...
NP_269934   288 DALAEVETphc-ktIDEVAAFLSVDeTQTIKTLLFVAdn-----ePVVALLVGNDHINTVKLKNYLAadfLEPASEEEAr 361 Streptococcus py...
NP_268284   288 LELEKVATpga-ktIDEVSKFLEIDeEQTVKTLVYHAdd-----eLVVVLLNGNDQLNEVKLTNYLGasfIEAASEAEVe 361 Lactococcus lact...
BAD64769    250 GLLEKRATpea-ktVDEAAEALGFDaDDIFKALVVVVdd-----vLSLFILRGNDELNEVKALHELGaktLRMASEEEVv 323 Bacillus clausii...
YP_753581   251 LELEKVHTpgq-rtIQDLVDYMNIPkEKQIKTLIYYAde-----eLVAAIVRGDRELNEIKFKNVLGcnqLFMADETAVk 324 Syntrophomonas w...
YP_818171   250 LALEKISTpne-ktIDDVATLLDKPkNELVKTIMFVAdd-----eLVAVVTTGDFEVNEVKVQNYLHadsLVMAEEADVr 323 Leuconostoc mese...
ZP_01594083 249 QALTKVHTpdk-ktIAEVAEFLGLPqSGTVKALVLSNge----gqFVMALVRGDHELNELKLKNRLGwdeIQMATDDEIl 323 Geobacter lovley...

Feature 1              ##                            #                           
1DBX_A       94 kstGYLVGGISPLGqk--krVKTVINSTALEfETIYVSGGkrglsVEIAPQDLAKVLg---AEFT 153 Haemophilus influenzae
YP_535458   324 kflGANFGSLGPVGid--enLKVLADLDVEGmINASVGANed--gYHYINVNIDRDYh--vDEFL 382 Lactobacillus salivarius subsp....
YP_804385   324 ellGAHVGSLGPVLenkpenLKIVADKYIEQmVNSVVGANed--gFHLKNVNVERDFt--vDEYA 384 Pediococcus pentosaceus ATCC 25745
ZP_01274506 328 kylNAHPGSLGPVGvs--eeVKILADNYVKVlVNMACGANed--gYHYINANIDRDFr--vDQFG 386 Lactobacillus reuteri 100-23
NP_269934   362 affGAGFGSLGPVNla--qgSRIVADRKVQNlTNAVAGANkd--gFHMTGVNPGRDFq---AEYV 419 Streptococcus pyogenes M1 GAS
NP_268284   362 ekfGAHFGSLGPIGle---nVKIIADRKVEQiKNAVVGANvd--gFHYKNANFGRDYe--vEEFV 419 Lactococcus lactis subsp. lacti...
BAD64769    324 aafGATPGSIGPVGvk---dVPIYADYRIRSmERIACGANet--gYHYVNVGPGRDYe--vTAYK 381 Bacillus clausii KSM-K16
YP_753581   325 qlcSAGFGSLGPVGl----pLKTYIDLEVSQmKNFACGANed--dYHFINVNLGRDFt--pAGIN 381 Syntrophomonas wolfei subsp. wo...
YP_818171   324 kavGAGFGSLGPVGlp--eeVKLLVDERAADlANFAAGANed--gMHYVNINWNRDVdllaENVS 384 Leuconostoc mesenteroides subsp...
ZP_01594083 324 rftGSPPGFLGPLGlk--aeLQVVADYAVETmADFVIGANet--dQHYTGANTGRDFq--iSQIA 382 Geobacter lovleyi SZ

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