5Y88


Conserved Protein Domain Family
NTR2

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pfam15458: NTR2 
Nineteen complex-related protein 2
Family members include the NTR2 or Nineteen complex-related protein 2 found in fungus and plants. NTR2 proteins form a complex with the DExD/H-box RNA helicase Prp43. Along with NTR1 it is an accessory factor of Prp43 in catalysing spliceosome disassembly. Disassembly of the spliceosome after completion of the splicing reaction is necessary for recycling of splicing factors to promote efficient splicing. NTR2 and NTR1 associate with a post-splicing complex containing the excised intron and the spliceosomal U2, U5, and U6 snRNAs, that supports a link with a late stage in the pre-mRNA splicing process.
Statistics
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PSSM-Id: 464728
Aligned: 64 rows
Threshold Bit Score: 73.6471
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y88_V        76 SHYEDLYHSKKn-----tNASTRNkddlLILNMEDLMEGnhhllsdsseagsssEGEHISSIPTRGEIAKLKAQKslsR- 149 Saccharomyces c...
Q754H1        47 AGYADLLQAPG-------RSPKAVpqalRTMNLEDLSDDd---------------DDDAYPVFSKQEILDIKKLRaerQq 104 Eremothecium go...
XP_003647532  95 HDYTDLFVISK----------EPKhvqeKIINLEGISDVd--------------DGDESE---LKEKVQEMRRHKivmDq 147
OEJ84289     104 KTINDLTVNINstptptpTFHSLAepkpEVWNMDDMEDEe----------------------dSDLVVLTEKQKEmllQk 161
SCW00937      76 VSYRKSAAGTA--------NVEDVrqdvRIMNMDDFDDGp---------------ESDLEGIPSKQDIESIKMQRtlmQq 132
CAR22443      80 DITEIAYRKPL------------PksgvQIMNLEELGDDc--------------EDDTLEGVPTRREIESIRTQRamlQq 133
CEP63617      79 TQYEIPYSAPAr---------------pQILNLENMSEEeqnde------dfdtSASDWKTVPSESEIETIRKRRailQe 137
SCU83114      76 RTHDITFSAKQn---------------sQILNLDNLDEDfdd----------gdEDELMFSVPSHSEIKRIRELRalqQq 130
XP_001643313  74 EEYSDIFHPSK------------NnddsKILNLSDMSDVdvmdsk----tndcsISDNDNVIPSKELIERLKSERrklS- 136
XP_003680941  70 TSYGDIFSKKPv---------------sRVMNLEDMAEEd---------------DDDSLSFPSKKEIEELKSNKlkaQ- 118
5Y88_V       150 ------------RKIsesdvtTerDYVKLLDSEDkreimetirlngglkrnnekEITN-----------FSDDEMQGFQD 206 Saccharomyces c...
Q754H1       105 e---------aaAGSavdqqfSekSYVRMLDREDkedlqellgrp--------------lhkglsedegPQEAEPEMISD 161 Eremothecium go...
XP_003647532 148 kyrts--htgfyDHAeksleyDekAYVRLLDSDDkeqlneilgkrrtntppgkyAQEFd----------DDAAAATMVED 215
OEJ84289     162 kmthgtfsslgsRNSqrdilkQenEYAKLLNQDDleelnaiynkgkgatatldnAKKLqipgngrlsedEDRLDQALLSN 241
SCW00937     133 rgtss-gtgfyaNSKkksveyDerSYVKLLNDDDkhelmetl-----gkkesteDVEVn----------ALEASLHEFDD 196
CAR22443     134 qtdtl-ktgfydSSknp-vehDehQYIKLLSKDDkhdlmeiiggesqgakdvqdSYMD------------AYLEIHGLED 199
CEP63617     138 qqsdysgtgfyaSKGkmtskeNerSYVKLLSRDDkqdlldvig---dgrkvdqeDSTTm----------PVDTLPSGFED 204
SCU83114     131 rvspt-gtgffdSSHekpvefNeaAYVKLLNEEDkldlletlg--ertagndktDVLS-------------EPMSNAFDD 194
XP_001643313 137 ------------EKPrnfgkvNerEYVKLLDKDDeveimeiieknggkqkknenDYIG------------LELDLGEFED 192
XP_003680941 119 ------------ATQkkkdaiSekVYVSLLDDDDkleimesikknggtentpsdPDID------------------MLDE 168
5Y88_V       207 E--------------MLALTDNQIAIQKDSKRKIIEKAINevp---yrTNEEWETQLLSKgninkSNEKII--------- 260 Saccharomyces c...
Q754H1       162 G--------------RLALSKSELSAEALRRKISIEDALNad-----lGGGVWESTQLNKhsrtaETR------------ 210 Eremothecium go...
XP_003647532 216 E--------------KLALTKSEAIDQTLRRKKEIEAALNhh----ddEGDEWETTQLNKfdkttNSTLK---------- 267
OEJ84289     242 EhfvedhntmmgghsKLALSEREKQIESLQRKRYITEQLDayg----------------------------------dhv 287
SCW00937     197 E--------------RLALSKAEITQKDDRRREEIEKALNd------kQSSEWETHQLNKvsnvgVI------------- 243
CAR22443     200 G--------------RLALSKNDLDRDEQERKLAITSALKn------vEGDEWEARQLEKmdrglSL------------- 246
CEP63617     205 S--------------RLALSEGELQKDEMDRRRAILSAINda-----hVEDEWETQQIGKtdnnsVA------------- 252
SCU83114     195 K--------------PLALSEQELRRDESERKTTILNALDd------vQDNEWESQQISKnengySI------------- 241
XP_001643313 193 N--------------RLALSSKEKLLESERRKDEIMKAVEvdsqshesDGDSWQEQIIKRstanvDSLQDGnifdskefm 258
XP_003680941 169 E--------------RLPLSSRESLLHKERLKQTIEEALKsqd---deSSNAWESQLLSKgsgqsQQAIDI--------- 222
5Y88_V       261 TPLPVLFPDDDEsgns-ierINEMV---SKICLQRKKVEMRLQALEKTKIDLEKSKA 313 Saccharomyces cerevisiae S288C
Q754H1       211 FYKPILSSAVSKyddlssaqLAVNLlgdGKTSQKMSLLHKQLAMVHSEISALTERQN 267 Eremothecium gossypii
XP_003647532 268 RQLPRRFKAQAEdihtieemLQTLLp--SNASIRISLLQKQLDLVQAELAALNIRKV 322
OEJ84289     288 VRAPHPKDMTQR----------------GSVLQIRQELQNSQETLVSELDEIKLELS 328
SCW00937     244 SSMPDLDTDIWTfdem-mknLNDLV---SSTQSKKTVLNGQIKAIYKECDALEGRKQ 296
CAR22443     247 IAHPILHENDFEleel-vseLDSML---LSIQTKKKMFISQRDSVQKENKKLCEAQD 299
CEP63617     253 VALPIPYQGKIDlesv-vsaLQDHT---LKVQAKKKILVARKVSLETQKNEFLREKD 305
SCU83114     242 ASLPITHGDDFSldsv-lseLKTLV---LKAQQKEKINFLRRDALQGERETLLNLRS 294
XP_001643313 259 VSLPTLSDDSHLegi--dikLSEMM---SSFTVRKKQLETQIKILENQKENTELNII 310
XP_003680941 223 PKLPKLHPSESEdnvndsdpLAQTI---ESVSFRKTQLMKQLTTLQAQKATLKTQQD 276
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