Conserved Protein Domain Family
C-C_Bond_Lyase

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pfam15617: C-C_Bond_Lyase 
C-C_Bond_Lyase of the TIM-Barrel fold
This family of TIM-Barrel fold C-C bond lyase is related to citrate-lyase. These genes are found in the biosynthetic operon, with other enzymatic domains, associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.
Statistics
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PSSM-Id: 406131
Aligned: 67 rows
Threshold Bit Score: 308.721
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_003969407             30 RMLSVALGATLYSPATRPSLADDVLKQAARGVVSMVLCLEDSIDDAEVIGAESNLIRQFAELAARDAAagpegrtegtaa 109 Stre...
ANG79089                  4 RLSPWNLGATLYMPATREDIADAVLHGKIPGLRSLVICLEDAVSEADIPVALKNLEHLLHELSNSMSSlg---------- 73 
PRJNA298211:APS44_24565   4 RLSPWNLGATLYMPATREDIADAVLHGKIPGLRSLVICLEDAVSEADIPVALKNLEHLLHELSNSMHSlg---------- 73 
WP_012124739              4 RLSPWNLGATLYMPATREDIADAVLNGKIPGLRSLVICLEDAVSEADIPVALKNLGQLLHELSNSMLSlg---------- 73  Cron...
LANL:CH62_133             4 TPSAYALGATLYMPATRTDIADIIIHNKISGLRSLVICLEDAVSEDDVPLAISQLSTLLGTLAVEKKRdg---------- 73 
WP_012988270              4 IPSPHQLGATLYIPATRQGIAEIVLHNKIPGLRSLVICLEDAVSDQDIPAAIENLDGVLQSLAGADISssh--------- 74  Xeno...
WP_013184744              4 IPSPHQLGATLYMPATRQDIAEIVLQNKIVGLRSLVICLEDAVSERDIPAAIDNLGGVLQILAEAGVRhagkq------- 76  Xeno...
Q6FAX8                    1 MLSALSLGATLYIPATRPDLWPIVTGEKYPELRSLVICLEDAITEQDVELAKQNLKQLLQKIQQQQWHe----------- 69  Acin...
jgi:PsycPRwf_0085        17 PLHPYQLGASLYMPATREDIWAVISRSKLPNLDSVIICLEDAVSESDVPYAWSNIQKLLSHWASVQQDtplsvsrsqcvn 96 
Q4FTQ0                   59 MHHPYQLGASLYMPATRQDIWQVIKRDKLPTINSIIICLEDAVSHNDVEVALERLQILLHTWATHVDSineptqq----- 133 Psyc...
WP_003969407            110 ----rdphgttdaagADVPLLFVRVREPAQIVDLVRRLgdSVRMLSGFVLPKFTEDRGKPFLEALAE--AEsecgrrLFA 183 Stre...
ANG79089                 74 --------------kNDWPLVFIRPRHAEMGRWLKAHY--DLSAVDGFVLPKFTLSSLAEWWDIMVG--TH------LCM 129
PRJNA298211:APS44_24565  74 --------------kNDWPLVFIRPRHAEMGRWLKAHY--DLSAVDGFVLPKFTLSSLAEWWDIMGG--TH------LCM 129
WP_012124739             74 --------------kNDWPLVFIRPRHAEMGKWLKEHY--DLSAVDGFVLPKFTLSSLAEWWDIMGE--TH------LCM 129 Cron...
LANL:CH62_133            74 --------------sAHWPLIFVRPRHEAMGLALITRF--NLSAINGFVLPKFTQASITTWWEIMKE--TH------LCM 129
WP_012988270             75 -------------teRDYPLIFIRPRNEEMGRYLVDNV--NLSAVDGLVLPKFTRASLAGWWNIVGS--TH------LSM 131 Xeno...
WP_013184744             77 ----------vsdtkRHHPLLFIRPRNEMMAKQLITNV--NLNAIDGLVLPKFTCASLPGWWEIIRS--TH------LCM 136 Xeno...
Q6FAX8                   70 ----------------QHPKVFIRPRHIAMAAELAEWQ--EITALDGMVLPKFGLANFKQWLDVLPA--TL------HY- 122 Acin...
jgi:PsycPRwf_0085        97 qideatgvqisavqkSNRPLVFIRPRNPQMLMQLAALP--NINLVDGYVLPKVDMDSLSNWRLACQQvqED------SLL 168
Q4FTQ0                  134 --------adiqpeqPTRPLVFVRPRHPVMLEQLSNFS--HIDLIDGFVMPKVDMYSLSNWRMACQNlsTN------MLL 197 Psyc...
WP_003969407            184 MPVLESPELLhletRGEILRGIARSVEKH--RDRVLALRLGVTDFCSAYGLRRAPDMTAYDvHIVASVIADVVNVLGRAd 261 Stre...
ANG79089                130 MPTLETEDVF----DVVQMRELATRLEEHpcHDRIIALRIGGNDLMNVVSLRRPRDLTLYD-SPMGYVIKMLVSVFGPR- 203
PRJNA298211:APS44_24565 130 MPTLETEDVF----DVVQMRELATRLVEHpcHDRIIALRIGGNDLMNVVSLRRPRDLTLYD-SPMGYVIKMLVSVFGPR- 203
WP_012124739            130 MPTLETEDVF----DVVQMRELATRLVEHpcHERIIALRIGGNDLMNVVSLRRPRDLTLYD-SPMGYVIKMLVSVFGPR- 203 Cron...
LANL:CH62_133           130 MPTLETEDVF----DVAKMSTLARELENHpsRQRIVALRIGGNDLMSVISMRRSRKLTLYD-GPMGYVIKMLVSVFCPK- 203
WP_012988270            132 MPTLETEEVF----DSRQLNQLADSLKAHpcYKRIIALRIGGNDLMNVISLRRSRDFTLYE-GPMGYVIKMLVTIFAAR- 205 Xeno...
WP_013184744            137 MPTLETKEVF----DVQKMNQLADILKAHpcEARIIALRIGGNDLMNVMSLRRPRDFTLYD-GPMGYVIKMLVAVFAAR- 210 Xeno...
Q6FAX8                  123 MPTLETADSF----DMEQMKELRQALPE---FHKVLVLRIGGNDLLNCLALRRPSDVTLYQ-TPIGTLIANLAGQFLPY- 193 Acin...
jgi:PsycPRwf_0085       169 MPTLETGRLF----DPAHNQALATALAHa-fDERVFALRIGGNDLFSALRLRRPSTQTIYE-TPVGTLMHQLIGTFVPQ- 241
Q4FTQ0                  198 MPTLETAALF----NPHHNQELAIGFKEa-fSQPVFALRIGGNDLFAALRLRRPKNSLVYD-TPVGTLAYQLLGCFVPH- 270 Psyc...
WP_003969407            262 gtGFTITGPVWEYFRRQErmfkpqlrrspflegraeelrtaliehdldGLLREIELDRANGLLGKTCIHPSHVAPVHALS 341 Stre...
ANG79089                204 --DFALTAPVCEHIDDHA------------------------------VMARELALDMAHGLVGKTAIHPGQIEVIQNAL 251
PRJNA298211:APS44_24565 204 --DFALTAPVCEHIDDHA------------------------------VMARELALDMAHGLVGKTAIHPGQIEVIQNAL 251
WP_012124739            204 --DFALTAPVCEHIDDHA------------------------------VMARELALDMANGLVGKTAIHPGQIEVIQNAL 251 Cron...
LANL:CH62_133           204 --NFALTAPVCEQIDNPQ------------------------------LLETELALDIAHGLVGKTAIHPSQIEVIQRAL 251
WP_012988270            206 --GFSLTAPVCEHIDDLR------------------------------LLEKELVLDIAHGLVGKTAIHPGQIEYIQRAL 253 Xeno...
WP_013184744            211 --GFALTAPVCEHIDDLK------------------------------LLEKELTLDITHGLVGKTAIHPRQIACIHQAL 258 Xeno...
Q6FAX8                  194 --GFALSAPVCEHFSQVK------------------------------LLQDELYLDLQYGLSGKTVIHPAQISIVHQAY 241 Acin...
jgi:PsycPRwf_0085       242 --GYYLTAPVCEYFDNTA------------------------------LFIQELATDVSLGLVGKTVIHPAQIALVQQAF 289
Q4FTQ0                  271 --GFYLSAPVFEYLDEPT------------------------------LFMQELTRDVSLGLVGKTVIHPSQIALVQQAY 318 Psyc...
WP_003969407            342 VVSHEEYTDAQDILSP-ERgggGVLRSAytNKMNEVKPHRAWAERTLQRAEVFGV 395 Streptomyces
ANG79089                252 MVTQGEHSDALRILNS-TQ---AVFKSQ--GAMCEPATHRRWAAGILDRARFYGL 300
PRJNA298211:APS44_24565 252 MVTQGEHSDALRILNS-TQ---AVFKSQ--GAMCEPATHRRWAAGILDRARFYGL 300
WP_012124739            252 MVTQGEHSDALRILNS-TQ---AVFKSQ--GAMCEPATHRRWAAGILDRARFYGL 300 Cronobacter
LANL:CH62_133           252 MVDTHDHADALRILNS-TQ---AVFKSQ--GAMCEPSTHKRWAAAILERAQYYGI 300
WP_012988270            254 MVNGHDYADALRILNS-SQ---AVFKSQ--GTMCEPATHRRWAVNILDRAKYYGI 302 Xenorhabdus bovienii
WP_013184744            259 MVSAPDYADALSILNA-KQ---AVFKSQ--GVMCEPATHQRWAMNILERAAHYGI 307 Xenorhabdus nematophila
Q6FAX8                  242 QVNEIELKQAQDILQDgCK---AVFACH--GSMLEPATHRRWAERILERAKVFGL 291 Acinetobacter baylyi
jgi:PsycPRwf_0085       290 SVSTRVLEEAQAILAQdAK---AVFKHN--NTMLEPATHYAWAVQTVKRAQIFGV 339
Q4FTQ0                  319 CVPLSILDEAQAILHSeAK---AVFKYN--NTMLEPATHRAWATEIVNRAQVFGT 368 Psychrobacter arcticus
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