3HQI,2Q81,3E4U,3GA1,2Z8H,3B84,1NN7,1BUO


Conserved Protein Domain Family
BTB
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smart00225: BTB 
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Broad-Complex, Tramtrack and Bric a brac
Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.
Links
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Statistics
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PSSM-Id: 197585
Aligned: 209 rows
Threshold Bit Score: 42.6781
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3HQI_A        176 DCCLCVAG-QEFQA-----HKAILAAR-SPVFSAMFEHEMEES------------------------------------- 211  human
NP_012265     123 DITFRVSNgKLFTA-----HKFLLCAR-SEILAEKMVNEWAK-------------------------------------- 158  Saccharomyces...
NP_587711     620 DVTIYCGT-SMFHS-----HKFILCAR-SSFLRKLLLQKKKSSvsniiy------------------------------i 662  Schizosacchar...
NP_498473     233 dfiIVASCgREFPT-----HMCILAAR-SEYFKVLLRNHSTKEf------------------------------------ 270  nematode
EGA85824       27 VFKIRIGQ-KLFEI-----SGATLNSDaPNFFTQFFNTh----------------------------------------- 59   Saccharomyces...
EGA79516       28 mykIQVGK-SLFKI-----SGASLSSDgPSFFTEYFSKKRSPSnnddsn------------------------------n 71   Saccharomyces...
NP_494231       7 iVKLNVGG-TVFVT-----LKSTLTKH-HGIFKALVKTEMPAE------------------------------------- 42   nematode
NP_001122573    5 tVKLNVGG-TVFET-----LKSTLTKH-DGFFKALIETDVPAe------------------------------------- 40   nematode
T25980          4 iIKLDVGG-TIFKT-----SKDTLTKL-DSFFKTMFESDIAPKl------------------------------------ 40   nematode
T31922         20 ffyFSIEQ-KYFSArfspqNQRFLKDN-SARSGGLKKTRKKHTekgggsgqyaanappltpilslglsknlenkinnyyk 97   nematode

3HQI_A        212 -----KKNRVEINDVEPEVFKEMMCFIYTG---KAPNLDK-------MADDLLAAADKYALERLKVMCEDALCSNL 272  human
NP_012265     159 ------HEIVSLEVR-PDIFDIFLKFLYLI---PILHQIEp-----gQYEELIELSSKFDIELLPEFLDKARHTAD 219  Saccharomyces cer...
NP_587711     663 eeitqSHSTIRVEDIPPLAVAILLHYLYTD---TLLSPWHldsrfspLKENLSKLANLLELPHLAEVLPFSVSRQP 735  Schizosaccharomyc...
NP_498473     271 -----MSKRLQFDDISARTLDVLLRHMYASaagRVVKLEEd-----qLTEDLISAMDRLMINSLRDEVARLIGSKV 336  nematode
EGA85824       60 -----DKNTILFVDRSEDVFIIIYRHLQGY---FPDIKNEv------QFTCLFADALYFQLPKLVKLIKEYDYHFT 121  Saccharomyces cer...
EGA79516       72 dtmesNKNEVLFIDRSAEVFEWIYQHLQGY---IIEIKDEv------QYTMLFADAMYYNLPRLRSLLKETDYYFT 138  Saccharomyces cer...
NP_494231      43 ------DGDSFFIDRSPKHFETVLNYIRSG---DVDLPDSe-----nELKELKREAEYYSLEKLATLCQSSMPKIK 104  nematode
NP_001122573   41 ----kDDSNCFFIDRSPKHFETVLNYMRSG---DVVLPDSk-----kDMLELKKEAEYYLLSNLAKLCQPPTDNFK 104  nematode
T25980         41 -----EKSGCIFIDRSPKHFELILNLMRDG---NLWLPETe-----kELRELCAEANYYQMFGLYNKCGVKLSTII 103  nematode
T31922         98 fqlqkDDSNCIFIDRSPKHFDIILNFLRDG---DVDLPEQe-----kEINEVKREAQFYLLEELVDLCHRKINTKI 165  nematode
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