1AOI,6K00,2CV5,5WCU,2XQL,6K0C,5CHL,4M6B,2RVQ,5VEY,5BT1,1U35,6A7U


Conserved Protein Domain Family
HFD_H2A
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cd00074: HFD_H2A 
histone-fold domain found in histone H2A and similar proteins
Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Links
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Statistics
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PSSM-Id: 467020
Aligned: 116 rows
Threshold Bit Score: 81.0402
Created: 1-Nov-2000
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2CV5; Homo sapiens Histone H2A interacts with DNA within the nucleosome structure, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ###  #       ##  #           ####                             ## #              
1AOI_C        12 KTRSSRAGLQFPVGRVHRLLRKGNy--aERVGAGAPVYLAAVLEYLTAEILELAGNAArd-nKKTRIIPRHLQLAVRNDE 88  African clawed ...
2CV5_C        16 KTRSSRAGLQFPVGRVHRLLRKGNy--sERVGAGAPVYLAAVLEYLTAEILELAGNAArd-nKKTRIIPRHLQLAIRNDE 92  human
Q54HV9       178 SSRSTRAGLTISVSRVEKLLRGRRy--sKRVSPTSCVFLAAVLEYMVLELLELSLNELslskKSRRIKNRHINLSILKDV 255
EFX87422       1 KSSPKRTGIRFPVKKLKFRMLSDYs---IDICKDAPVYMAAVLEYLVTEVISFAGEAAn--aRMSKIKPRHLQIVFQNNE 75  common water flea
XP_028156301  33 QSLTSRAGLKLPVSHVDKLIRQLVp---QKINRPASIFLTAVLQYLCSELLVISKMAMe--tREKLILPRHIEKAILHDD 107 Asian corn borer
XP_012756156 127 KPPAKNAGLIVKPSYVRKQLKIAGf---GRVAKMASVYFAAVLEYVLSEVLELSSNNAqs-cGKTTITSQHIFFAVSNDA 202 Acytostelium su...
EFA86344     323 GSKKSKEVYIIKASKIRMALKRTGm--fQRVEKMAMEYLAAVIEYIISEVLELAYNSCiq-fKKYRIMASHINTGIRSDM 399 Polysphondylium...
XP_003292215 535 VSLSKKCGLTFPVSRVHSILKSNKffkvPRISKCSTVYLTAVLQYVCEELLILSMEYCeq-rKRNRIQRRDILKSIKRDC 613 Dictyostelium p...
KYQ90844     132 DDKTTKFTSVIPPSYIKRQIREKMac-sLRFGKAFHVYLAAVMDYLLSEILELASNIAkt-eHKRIINPHMINMAILNDQ 209 Tieghemostelium...
QBK85747     120 VRRETLAGLVFSVALSEKYLREFGas-eLHVGKMAPIALSAILQYVIGEILRFAINCArd-lKRVIVKVRHIRLAVGNDP 197 Marseillevirus ...

Feature 1                    
1AOI_C        89 ELNKLLGRVTIA 100 African clawed frog
2CV5_C        93 ELNKLLGRVTIA 104 human
Q54HV9       256 ELSALLNDVIIC 267
EFX87422      76 ELRELMTGEDRS 87  common water flea
XP_028156301 108 EIARMLPGVIIS 119 Asian corn borer
XP_012756156 203 ELNSLCEHVTFP 214 Acytostelium subglobosum LB1
EFA86344     400 ELDSLFKDVTIA 411 Polysphondylium pallidum PN500
XP_003292215 614 EFKRIHNNLIIN 625 Dictyostelium purpureum
KYQ90844     210 ELSNMFHNTTIP 221 Tieghemostelium lacteum
QBK85747     198 DISQLFQNFKIE 209 Marseillevirus LCMAC101

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