Conserved Protein Domain Family
TMEM43

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pfam07787: TMEM43 
Transmembrane protein 43
This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.
Statistics
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PSSM-Id: 462267
Aligned: 58 rows
Threshold Bit Score: 139.743
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A0BGH4           125 TYQWVQKSREEGSKKN-----KRTVYYYESEWSSKIEGSYPNH-------ENRrEDLTVQEQELTAENVYI---G-AYKL 188 Paramecium ...
Q8F2H1           115 VYAWDEQVKTEGSGSNkke-----vrNCVLKWTSSPENPSSFKlsg--crTKRyYRKSVQDQSDSASGALVhadGkNYSV 187 Leptospira ...
WP_014373579      98 MYAWKEDKDSKTKKNIggsetTTTDYSYRKVWTSSPENSSNFKvd---gyHNP-S-MSISGEELRAKEIEM---E-GFRL 168 Saprospira ...
jgi:Cal7507_5568  82 MLSWVEEQSQVSEN-------NPPEYTYTQLWLEYPPNSGKFKere--nhKNP--TLKIHSNSQSVQTANI---G-VYKI 146
XP_004030327     132 IYCWQEYKHSRRISNNy----EEIYYTHNIDWRNEFIDSQYFHeni--ghQNYkQDWLYDSKVIYAPNVFF---G-TFKL 201
A0DSK3           154 MYQWVRKTKEEN---------NTTVYYYVQEW------NTTFHsdcgeghFNNkNYWIVEQETQINMNVRL---G-AYLM 214 Paramecium ...
A0EH31           120 MYQWVVGEKQK-----------------EQQWVDHYVENSFGY-------NNDkSKWILNSETFLNISVKL---H-QFEL 171 Paramecium ...
A0BGH2            27 MYQWVKGDQKQ----------------YEQKWVDHHVENHFGY-------NNDkSKWVLKAQTFLNQCVKL---H-QFML 79  Paramecium ...
EFC50659         140 FCQWIESSRDETVKNRdgsetTVRTYYYTKGWVDHLIPSLAFDqpa--ahHNP-QRNPFPSMKSHASGVSV---G-KYHI 212
XP_001298636      92 YCMWTELEHSETINNV-----THYSYTYHKMWTHRPINSLFFHnpt---yhNP--SVEIIPERSFHNQMKA---G-TFFL 157
A0BGH4           189 T-DYLKSKAVDYVQVDSISQQQCEAAkvafqsrT---------QQYIFFDGRYIQFRKSENS------------------ 240 Paramecium ...
Q8F2H1           188 Q----LEDVDFTSQVPSRDANENEIL-----------------AGRFVYGDGYLYSSKSCVEs----------------- 229 Leptospira ...
WP_014373579     169 EqPE-------DLSLTSEEL-SLSQSml---kgQ---------SGVVWASDRYLFSGRGSLEa----------------- 211 Saprospira ...
jgi:Cal7507_5568 147 D--PLQISLPEPTEIQLTDSDVVIPKpktktdlilsptflslvgsiprregNYIYIGSG--------------------- 203
XP_004030327     202 S-EKQKEMCENSEIIRMNQQQYq----------G---------HKQIQIIQDYIYFRKIPNQ------------------ 243
A0DSK3           215 S-KSLAEQTNAKESIPMNLHNAQVVAnfygyekG---------FTNYEANEQYIYFQQNKGA------------------ 266 Paramecium ...
A0EH31           172 P-EDMKTQLNTPLETVKLNQANVQIFqqrykdkG---------YRRFLLQDDYIYMHQVEDQ------------------ 223 Paramecium ...
A0BGH2            80 E-EDMIKELNTPLQNVKFNQANVQIAqqkykdsG---------FSRFLLQDDYIYMHQVDDQ------------------ 131 Paramecium ...
EFC50659         213 G-PTLITKNQIPERTISFSKNQLESIrgt-vanT---------QHNFKYIGSGYFFSAYEPSnfektlrtlfgfvegsll 281
XP_001298636     158 S-DSLSYSGSTDTLHPHNQQIVQFQNs-----pY---------AKQFQFAGRGIFYSTYKDGyletllkvgqf------f 216
A0BGH4           241 ----------QSIGDQRVLFEKV--PCN-YAAIVARQ---HKE-SFKP---Ylfkdsfsddvnqdyaknpdmlksfnrfh 300 Paramecium ...
Q8F2H1           230 ----------EKEGCERIKISVIpiPEG-DMTFVGDV---KGN-RVGQ---F---------------------------- 263 Leptospira ...
WP_014373579     212 ----------PKVGDLRISYEALpsPSP-QLTLFAAY---ASSaSLAP---F---------------------------- 246 Saprospira ...
jgi:Cal7507_5568 204 ----------LLAGDVRIHYEGV--PQLkNVTVFGKL---DKN-QIVP---Y---------------------------- 236
XP_004030327     244 ----------NSCGDFRVQFTKC--TCG-ESTIIAKQ---HQN-TFEV---Fhpgdynegdthfgd-------------- 289
A0DSK3           267 ----------ITMNDLRVSFNAS--KTG-PTTVITYQ---QND-TFTP---Fvfqdkfnqtlardqnfenl--------- 317 Paramecium ...
A0EH31           224 ----------IVNGDLRICFKQV--ICS-DATIVARA---IIN-SLLV---Wqfedtynktvskqnq------------- 270 Paramecium ...
A0BGH2           132 ----------IVNGDLRISFKQV--ICS-DATIVARG---DTN-RLLV---Wqfedtfnktvardyd------------- 178 Paramecium ...
EFC50659         282 dwqvadlftsCEAGDIRIKFIDQkpALGkGVTIIGRQvstNGEiELLK---A---------------------------- 330
XP_001298636     217 dlgsrgysewCEPGDRRVWFEYW--APE-QVTVIGKA---MNG-LILPvslY---------------------------- 261
A0BGH4           301 elseeeqplnqidpssevssnifKSyeAPLNYINWYFNRSF-TLDQCFQSQLSKLVRMVWLCR--VGGFFMFLF------ 371 Paramecium ...
Q8F2H1           264 -----------------------VS--SEGNKFLNASVGNF-A--ETMADIKSDDNTMKWVGR--LIGFIAMFS------ 307 Leptospira ...
WP_014373579     247 -----------------------SN--NKVNGFYRALKG---DKEQAVDYLQTEHNTIRWILR--GLGFFLMWM------ 290 Saprospira ...
jgi:Cal7507_5568 237 -----------------------PY--KNSRIYNVYYGNRD-AAIAEINSQYKANLGFFLLMP--IVGFLLMWIivysys 288
XP_004030327     290 ---------aqccsccfsicefcRFlnQAVDEINWIKEKHI-SKEEFFNEKLQSQEFKTWLIR--LCGYLLLVF------ 351
A0DSK3           318 -----dnvefncancccfickyfRSieKPITEINWIYESIL-TLDQVFQKKADENQCTTTLQR--LGGYTIMGV------ 383 Paramecium ...
A0EH31           271 ------------vqekelsdtqlpnedKPIKQIYWIFQGLF-TPEECLQKVVNENALLFWVFR--SIGYILIAV------ 329 Paramecium ...
A0BGH2           179 ------------ahertccnlpvpndsKPIKDIYWIFQGLF-TPEECFSKVVNENALLFWVFR--SIGYILIAI------ 237 Paramecium ...
EFC50659         331 ---------------------------SNGYNVGEVHEGQFnSPRELFDATIS---IYRWSTL--LGARILIII------ 372
XP_001298636     262 -----------------------------DYKIGSAISGFVtTRDAIANNFSIIPTIFKWVMRasISGLILYFLsqniqf 312
A0BGH4           372 ----------GFVLLFTPITTLLYYIPLLggflSKLTGIVLAFLSGMISMPLTLGTIGIAWLYYRP 427 Paramecium tetraurelia
Q8F2H1           308 ----------SFTLMAGPLTSLLSFIPFVgdlgGGLIKVVLG----IVAFIITAITILLIKFWYIW 359 Leptospira interrogans
WP_014373579     291 ----------GLAMISGPVSVFLDLVPIA----GRISRALVGFASFLISAVLSTVTIIVSLIIHSW 342 Saprospira grandis
jgi:Cal7507_5568 289 pqptscrltfGIAIFISIVAIAVSCITY--------------NYFWVLFISLLLLVVALRWFQRRI 340
XP_004030327     352 ----------GIFLMLSPIYKLLYWFPFVgkflGTIGSLICLLVGLIVAIPPAIIVIGLAWLFYRK 407
A0DSK3           384 ----------GFWFIFSPITFIVSVLPFIgnflAQIT------VSFTISIPFSILIIAFAWLFYHP 433 Paramecium tetraurelia
A0EH31           330 ----------GSIILLSPVSQLSQLIQS-----DQLSGFGFIIYGLIGAIPINIFSICFCWLYYRP 380 Paramecium tetraurelia
A0BGH2           238 ----------GTIILLSPVSFLTDFIPI-----EKLTGISFFIFGCIAAVPITIFAICFSWVYYRP 288 Paramecium tetraurelia
EFC50659         373 ------------------WAVVISLVML-----GDYITSGTDI--FLSTISLSSLMIGLVWLSLTF 413
XP_001298636     313 nysyfgliiaGIILAQPMISGKYC------------------INKSTGGLLLFSAVVALPNFVFRY 360
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