Conserved Protein Domain Family
Na_H_antiporter

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pfam03553: Na_H_antiporter 
Na+/H+ antiporter family
This family includes integral membrane proteins, some of which are NA+/H+ antiporters.
Statistics
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PSSM-Id: 281542
Aligned: 32 rows
Threshold Bit Score: 125.874
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y8U6 161 VAGMMLVSTWIGFEVGLIKEAIaTLEEEALaglipaaptieAYAAWLQSvpYRFYSIFALLLVLLVVL------TRRHFG 234 Aeropyrum pernix
Q97L22 149 GVYFGDRCSPMSSSAALVANLTkTNIFTNMk----------N--MIYSSivPFSLSLFFYYILSISQP-------LRNMN 209 Clostridium acetobuty...
Q57007 162 GAYFGDKLSPLSDTTNIASAAAgVDLYEHIa-----------H-LLYTTlpSFILSATVYVVYGLNYDfsn-vatPEKVN 228 Haemophilus influenza...
Q2G2J3 158 GAVFGDKMSPLSDTTNLAALVTkVNIFKHIh------------SMMWTTipASIIGLLVWFIAGFQFKgh---sNDKQIQ 222 Staphylococcus aureus...
Q9KQG1 161 GCYFGDKMSPLSDSVILASSMSnVEVMEHIk-----------G-MLPIAliSYVITGILFTLFGFHYAgn---vdMSQVE 225 Vibrio cholerae
P54571 159 GAYFGDKLSPLSDSTVLASSLSkVDVLAHVr-----------A-MLYLSipAYVITAILFTVVGFMYGgkn--idLDKVE 224 Bacillus subtilis sub...
Q9HHN1 171 GVYMGDKQSPLSDTTLLASGVSdVDLWDHVr-----------G-MFPNTiiVGVISLALYAVLGLMAEtggtggTGAEVA 238 Halobacterium salinar...
Q9HNF7 171 GAYAGDKQSPLSDTTNLAAAVTnADLYDHIn-----------G-MRLGTaiAFGLSVLAYAVLGVLIVdg----gAANVT 234 Halobacterium salinarum
P27611 157 GACFGDKMSPLSDTTNFAPGIVgVDLFDHIr-----------H-LLWTTvpSFVITVILFLMIGRSQAt----sTTQDIQ 220 Alkalihalophilus pseu...
O07553 159 GACFGDKMSPMSDTTNFAAGIGeIPIFEHIr-----------H-MMGTTipALLITVVLFYFLGSSVSada--asTDNIQ 224 Bacillus subtilis sub...
Q9Y8U6 235 PMLKAehrAVatgkvlrdgaqplmptetVLGEKPAAkthapawlfaVSIAVLIGVTLLgmwVTGGGD---RWWETSFIDA 311 Aeropyrum pernix
Q97L22 210 SNLSNeisG-------------------TFNIAFITl---------FPAIIILILSLFkvkLYFSASi-sIIIASIFALV 260 Clostridium acetobuty...
Q57007 229 TMIHEleqVY------------------HFNFLLLI-----------PVAIVLWGSITkkpTIPVMLlsaFI-AIINAIL 278 Haemophilus influenza...
Q2G2J3 223 TLLSElaqIY------------------QINIWVWV-----------PLIVIIVCLLFkmaTVPAMLissFS-AIIVGTF 272 Staphylococcus aureus...
Q9KQG1 226 TVIAAmeqQF------------------YITPYSFV-----------PVLIVLGLLAMrmpSFPVISfgsLL-GIVWAVM 275 Vibrio cholerae
P54571 225 FLKSSlqnTF------------------DIHIWMLI-----------PAVLVIVLLAMkkpSMPVIVigaLL-GAIWAVV 274 Bacillus subtilis sub...
Q9HHN1 239 QIQGGlagTY------------------TLSVLVLL-----------PLVITFGLAIKgypALPSLGagvFS-AAGVSIL 288 Halobacterium salinar...
Q9HNF7 235 AISGPlagSY------------------ALGPLVFL-----------PLVVTFGLAFRgypALPSLVagvFA-GALTTIA 284 Halobacterium salinarum
P27611 221 AMLTAldsQF------------------TLSVLTLLs----------PLLVVI-LAMRrfpTIPVLVvgiLT-GIITAAF 270 Alkalihalophilus pseu...
O07553 225 QVITGikdAA------------------NVTPWALLs----------PLLVVL-LAMKrvsVIPVLTagiISSGILTAIF 275 Bacillus subtilis sub...
Q9Y8U6 312 LmnadsaTALLWGSFAAYLVALAGALAtrslSFSTAMEYTVKG-MYLMVYANAILLLAWSIKSAADAVG-TAEYVVHLAT 389 Aeropyrum pernix
Q97L22 261 FqqhnllDIIKFIILG-FQTSPHSP----------LHNVLKGGgIVSMLQPCLVMFVSCSLSGIFKELNiFNSFKKVITN 329 Clostridium acetobuty...
Q57007 279 IqkfslsDVIN-SAVNGFDTSMIHHTsv----sSDLSRLLNRGgMNSMMGTLLICFCALSFAGVLQLSGaLTVIIQKLLT 353 Haemophilus influenza...
Q2G2J3 273 NhhfkmtDGFK-ATFSGFNESMIHQSH----ISSSVKSLLEQGgMMSMTQILVTIFCGYAFAGIVEKAGcLEVLLTTISK 347 Staphylococcus aureus...
Q9KQG1 276 IqdvdflQAFN-TAWAPYNIESGVSF---------IDAILNRGgMSSMLGSVAVIVFGLGFGGLLDRVGvLETIAKLFER 345 Vibrio cholerae
P54571 275 FqgmdiaHAIA-TAYNGFSIKTDVEF---------LNGLLNRGgIVGMLDSLVVIIFGLGFGGLLEKLGvLKVIVSTFEK 344 Bacillus subtilis sub...
Q9HHN1 289 IqgrgfaEAWQ-IIYSGTGPKTGVDL---------VNNLLSTGgLEGSIWVITIVFGALSIGGILEATGvLSVIAHNTAK 358 Halobacterium salinar...
Q9HNF7 285 VqgasftAAWD-IFLNGTTPETGSEL---------VNNLLTTGgIAGSAWTIAVVVAALSLGGLLERTGvLPTLTHHLTR 354 Halobacterium salinarum
P27611 271 VqgnadvARWFTIIQNGFSMETGNEV---------IDGIVNRGgLQSMMWSISLVMIALTLGGVIQRIGvIDTLLQSLTR 341 Alkalihalophilus pseu...
O07553 276 Vpys-slQAFMTALQNGTTFETDNEA---------AAKIINRGgLQSMMGSVSLIMIAFALGGLMEKIGlISALLEGVMK 345 Bacillus subtilis sub...
Q9Y8U6 390 AAgVSPLLVPPIIFLSAMFISFTTGTSWGTFGIMMPIAVPMAWKLAIQTgdvdlaytvmYASIAAVFAGGIYGDHSSPIS 469 Aeropyrum pernix
Q97L22 330 KN-LTKHKLFSVISIVSIMTAAFGCNQTISSVMTNEIMKDSYKNIGKYR------------FALDLENSGIIIAALIPWN 396 Clostridium acetobuty...
Q57007 354 FV-HSTLSLIITTILCGLTMIGVTCNGQISILIPGEMLKNAYVEKGLHP----------KNLSRTAEDSATIIEPILPWT 422 Haemophilus influenza...
Q2G2J3 348 GI-HSVGSLICITVICCIALVFAAGVASIVIIMVGVLMKDLFEKYQVSR----------SVLSRTLEDSSTMVLPLIPWG 416 Staphylococcus aureus...
Q9KQG1 346 RV-TSPGSLATSTIGTAFMGNVFGSAMYVSLILTPKICAKNYDRLGYQR----------KNLSRNAEFGGTLTSGMVPWS 414 Vibrio cholerae
P54571 345 KL-TSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR----------RVLSRNSEVGGTLTSGMVPWS 413 Bacillus subtilis sub...
Q9HHN1 359 AV-DSVGGATLVTALGPLVINALTADQYMSIVIPGMTFRDLNDEYDLDG----------TSLSRTLEETGTVSEPMIPWN 427 Halobacterium salinar...
Q9HNF7 355 AI-WSPESLVAGTGVAAIATNAFSAQQYMSIVVPSVSLRTLYDEYDLNE----------RDLSRAVEAAGTPTGPFFPWH 423 Halobacterium salinarum
P27611 342 KL-SSRGHLIAATATSSIGVNVVTGEQYLSILLPGKTFESFYTKLNVAK----------KNLSRTLEDAGTLVNPLIPWG 410 Alkalihalophilus pseu...
O07553 346 GI-RSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQR----------KFLTRSLEDGGTLINPLIPWG 414 Bacillus subtilis sub...
Q9Y8U6 470 DTTIMSSMFTGAD--HIDHVN-TQIPYALWAAit-ggVLYVLFAI 510 Aeropyrum pernix
Q97L22 397 ISALVPTTTLN-----VSAIKyIPYAFYLYMLpiiyfIYLRYSNK 436 Clostridium acetobutylicum
Q57007 423 AAGAYMAGTL-----GVATLSyLPWAILCWSGii-faIIYGASGI 461 Haemophilus influenzae Rd KW20
Q2G2J3 417 TSGIYYTNQL-----HVSVEEfFIWTVPCYLCai-iaIIYGFTGI 455 Staphylococcus aureus subsp. aureus NCTC 8325
Q9KQG1 415 DNGIYMASIL-----GVATLSyAPFMWLSFVCil-vtIITSYCGW 453 Vibrio cholerae
P54571 414 DNGIYMAGIL-----GVSTFSyLPFMWLSFVAig-laIIYGYTGK 452 Bacillus subtilis subsp. subtilis str. 168
Q9HHN1 428 SGGVFMASAL-----GVPVLSyLPYYFVGILSpi-lvVIMGFTGW 466 Halobacterium salinarum NRC-1
Q9HNF7 424 AGAVFMTGALYTSqpGAISWWwAPYYFFGILSpl-vlFGLVLAGR 467 Halobacterium salinarum
P27611 411 VSGAFFASTL-----GVDVIDyLPFAFFLFLSpf-mtILFGYLGI 449 Alkalihalophilus pseudofirmus OF4
O07553 415 VSGAFMASAL-----GVPVIDyIPFTFFLYISpm-isILIGFVKK 453 Bacillus subtilis subsp. subtilis str. 168
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