1RWR,4RT6


Conserved Protein Domain Family
TPS
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pfam05860: TPS 
TPS secretion domain
Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.
Links
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Statistics
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PSSM-Id: 461762
Aligned: 41 rows
Threshold Bit Score: 112.797
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1RWR_A      1 QGLVPQGQTQ---------VLQGGNKVPVVNIADpnSGGVSHNKFQQFNVANPGVVFNNGLTDgvsriggaltknpnltr 71   Bordetella pertussis
Q9CPI1    122 AHHDAKGDHQt-------kIKHTENHVIIVDIAKpnQNGISDNRFKKFNI-PNGAVFNNSAKEkrsqlvgylpgnqnlte 193  Pasteurella multo...
AAP96012  108 KQTAVDERDPkn----------gKEKVVVINIAKpdEQGISDNHFSKFNI-PNSAVFNNSIKEgnsqlvgllg-enknlg 175 
Q7VLE8    104 GKVYVDSQHSstriyeqktNDNSKDGIVVVEIANpeVDGVSDNRFKEFNI-PNSAVFNNSRTEstsqlvgkl--haniql 180  [Haemophilus] duc...
Q9HVG6     40 AMAAPTGAQFnpn---eikISQQGKTTLIDQSTQ-----RAIINWKGFDVSADEAVRFNQPGV----------------- 94   Pseudomonas aerug...
4RT6_A      2 ARDLPQGSSVvvg---eanVSTIGNKMTIDQKTP-----TTQIDWHSFDIGQNKEVEFKQPDA----------------- 56   Haemophilus influ...
Q8XQ42     54 AFAAPAGGTVtsg---sgsIGQNGTTTTITQTSS-----RLAIDWSAFGIQAGETVNFIQPGA----------------- 108  Ralstonia solanac...
Q9HVN6     51 AFALPSGATVvsgd-agfqTSTDGRHMVIDQQSH-----KLITNWNEFSVRADERVSFHQPGQ----------------- 107  Pseudomonas aerug...
Q9HWU6     51 AYALPSGGTVvggsangeiHLSGGNSLSVNQKVD-----KLIANWDSFSVAAGERVIFNQPSS----------------- 108  Pseudomonas aerug...
Q9I5N6    133 A-SLPFEQAWqnakgpvqtQAAGKTTVSIEQTAD-----KAVLNWETFNVGRNTTVDFQQHADw---------------- 190  Pseudomonas aerug...

1RWR_A     72 qasA--ILAEVTDTS--PSRLAGTLEVYGKgADLIIANPNGISVNGLSTLNASNLTLTTGR---PSVNgGRIG------- 137  Bordetella pertussis
Q9CPI1    194 gaeAkaILNQVTGPD--ASKIEGALEILGQkADLVIANQNGIVLNGVKTINANRFVATTSS---TIDPeQMQ-------- 260  Pasteurella multo...
AAP96012  176 sqaAktIFNQVTGDQ--ESKISGGLEVFGEkADLFIINPNGVTLNGVKTINTDRFVASTSEvvePHIKq----------- 242 
Q7VLE8    181 qkeAklILNQVTGDH--ESNIQGALEVAGKkADLIIVNPNGITLNGVKTINTDRFVVSTSD----IIPhRENGl------ 248  [Haemophilus] duc...
Q9HVG6     95 ---TssTLNRVTAGQ--ESVIAGRISAPGQ---VIIYNSNGVVFSGSAKVDVGSLITTTAN---ISDEhFRQGklif--- 160  Pseudomonas aerug...
4RT6_A     57 ---NsvAYNRVTGGN--ASQIQGKLTANGK---VYLANPNGVIITQGAEINVAGLFATTKDlerISENgNGNGnk----- 123  Haemophilus influ...
Q8XQ42    109 ---GaiALNRVTGHE--ATSILGSLNANGT---VFILNPNGVLFGSGAQVNVGGLVASTLG---LSNAdFEAGryals-- 175  Ralstonia solanac...
Q9HVN6    108 ---DavALNRVIGRN--GSDIQGRIDANGK---VFLVNPNGVVFGKSAQVNVGGLVASTLD---LADRdFLAGny----- 171  Pseudomonas aerug...
Q9HWU6    109 ---SsiALNRVIGTK--ASDIQGRIDANGQ---VFLVNPNGVLFGRGAQVNVGGLVASTLDitdAEFNgNSSRyr----- 175  Pseudomonas aerug...
Q9I5N6    191 -----aLLNRVNDPSarPSQIQGQIKADGT---VMLVNRNGVVFSGSSQVDVRNLTVAAAN---ISDEqFRQRglyydna 259  Pseudomonas aerug...

1RWR_A    138 -----LDVQQGTVTIERGG--V--------NATGL-GYFDVVARLVK------LQGAVSSKQgkplaDIAVVAGANR--- 192  Bordetella pertussis
Q9CPI1    261 -----LNVTQGTVTIGVDG-----------FATDGlPYLDIIAKKIEqkq-aiTKERTGNSEt----DITFVAGNSK--- 316  Pasteurella multo...
AAP96012  243 -----LNVQRGKVIIGKDG-----------VATNGlSHFDVVAKNIEqqgkvsIEGDSKPAKl---aNVTFAAGNLT--- 300 
Q7VLE8    249 -----LSVRNGKVTIDKGG--V--------ATNGL-SHFEVVARNIDqkg-kiTVAKTENQKsvnpaNITFAAGSLN--- 308  [Haemophilus] duc...
Q9HVG6    161 ---dqpgNPDARIVNDGSI-----------SVAEK-GLAAFVAPSVA-------NNGVINARl---gTVAMAAGNAAtid 215  Pseudomonas aerug...
4RT6_A    124 ---ftRKLKDGQVVKEGQVinK--------GKIKAkDFVVLNGDKVI------NEGEIDATNn---gKVYLSSGYNFt-- 181  Haemophilus influ...
Q8XQ42    176 ggstaGVTNQGTITVPSGG------------------KVALIANSVD------NAGNISAPR-----GSVLLAGAGN--- 223  Ralstonia solanac...
Q9HVN6    172 ---qfSGDSGATVSNAGSL-----------QASEG-GSIALLGARVS-------NDGLIQAQl---gDVALGAGQG---- 222  Pseudomonas aerug...
Q9HWU6    176 ---ftGPSTNGVLNHGGAI-----------TAAEG-GSIALLGAQVD------NRGTVLAQMg----GVGLGAGSD---- 226  Pseudomonas aerug...
Q9I5N6    260 gsrptFTDAAGAVRVEQGA--QlrtaapsgSTRGG-GYVLLLGSEVD------NAGSIVTPKg----QTVLSAGDSF--- 323  Pseudomonas aerug...

1RWR_A    193 --YDHa--------------TRRATPIAAGARGAaaGAYAIDGTAAgamyGKHITLVSSDSGLGVRQL-GSlssp-saiT 254  Bordetella pertussis
Q9CPI1    317 --YDL---------------NTHQVTEKHTAEAQ--GEIAISGASTgamyGKNIKLIVTDKGAGVKHD-GIilseadiqI 376  Pasteurella multo...
AAP96012  301 --YDVntrd--------vnrNTNPKKPITDNTRK--DNIAISGESAgsmyGRNIKFIVTDKGAGVNHQ-GVifaeddinI 367 
Q7VLE8    309 --YNL---------------KTREATPISSGTSRtsDTPAISADSAgsmyGSNIKFVVTDKGAGVKHK-GIifsendinI 370  [Haemophilus] duc...
Q9HVG6    216 lyGDGlvsiavtdpvtrkpqDAQALVSNGGAIQAdgGSVLITAEQAsrvvDNAVNLSGVILARGTEVReGSv------aL 289  Pseudomonas aerug...
4RT6_A    182 --FTLsdssis---valednAVQSIVQNEGIIKA--GDITLNAKGRnqalDSLVMNNGVLEATKVSNKnGKvvlsaddvQ 254  Haemophilus influ...
Q8XQ42    224 --VTLtladgsplgytisagAARTLVNNGGMIVAdgGRVVLTARGLdslsESVVNTTGVVRARTVGNNqGTieli----g 297  Ralstonia solanac...
Q9HVN6    223 --INLnfdgdgllnlqvdkgSVDALAHNGGLIRAdgGQVLMSARSAdsllKTVVNNQGTLEARTLRSAeGRiv-----lD 295  Pseudomonas aerug...
Q9HWU6    227 --LTLnfdgnklldirvdagVANALASNGGLLKAdgGRVLMAARTAnallNTVVNSQGAIEARSLRGKnGRiv-----lD 299  Pseudomonas aerug...
Q9I5N6    324 --V-----------------IRRGQGTDGNLTSTtrGNEVLPGFAAds-sAGRVRNSGLVQAAT-----GDisl--sgrE 376  Pseudomonas aerug...

1RWR_A    255 VSSQGEIAL 263  Bordetella pertussis
Q9CPI1    377 ETHEGDVEL 385  Pasteurella multocida
AAP96012  368 LTDDGNSRL 376 
Q7VLE8    371 KMDGGNASL 379  [Haemophilus] ducreyi
Q9HVG6    290 VSKSGDIQI 298  Pseudomonas aeruginosa
4RT6_A    255 LNNKSDIKG 263  Haemophilus influenzae Rd KW20
Q8XQ42    298 dpvAGLTQV 306  Ralstonia solanacearum
Q9HVN6    296 GGEQGTVRV 304  Pseudomonas aeruginosa
Q9HWU6    300 GGPDGKVMV 308  Pseudomonas aeruginosa
Q9I5N6    377 VEQAGVLLS 385  Pseudomonas aeruginosa
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