5Z16


Conserved Protein Domain Family
IcdM

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COG2838: IcdM 
Monomeric isocitrate dehydrogenase [Energy production and conversion]
Monomeric isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Statistics
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PSSM-Id: 442086
Aligned: 222 rows
Threshold Bit Score: 1273.51
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Z16_A        10 EKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIVKSDISVAARVLAEFADYLSEEQKVSDNLAELGRLTQDPDTNII 89 
YP_002343962   1 --MQITYTLTDESPALATYSFLPIVKAFLSRAHIGVKTSDISLSGRILATFSEYLKEEQRCEDALELLGELVKRSDANLI 78 
WP_011397042   3 SNTKIVYTLTDEAPLLATYSFLPIIKKFASAAGVDVETSDISLAARVLANFPECLSEEQKVPDALAELGELVKQADANVI 82 
WP_041654413   4 SKAKIVYTLTDEAPALATRSLLPILETFAKPAGIDFETSDISLAARILAGFPDYLEEDQRVPDALAELGEYTKDPDANII 83 
WP_015045990   4 QTSKIIYTLTDEAPALATYSLLPIVNAFAAAAGIEVETSDISLAARILAHFPECLTFEQRVPDALAELGALTQDPNANII 83 
WP_020915457   4 NKSTIFYTLTDEAPMLATYSFFPIIKKFTTLANIKIISSNISIAARTLSKFSSYLRKDQKILDDLDELSKLIKKPYINII 83 
WP_062479996   4 SKSKIIYTKTDEAPALATYSLLPIIRSFAAPAGIEVETSDISLAARILATFPDYLNDDQKVPDALSILGELTQEPETNII 83 
WP_085759980   3 ELSKIIYTKTDEAPALATYSLLPIVNAFTKAADIAVEKRDISLSGRIIANFPENLSDEQKISDALAELGELTLLPEANII 82 
WP_087464161   4 PISKIIYTQTDEAPALATYSLLPIISAFAQKADVEVETSDISLSARILANFPENLTDEQKVPDALTELGELALDPSANII 83 
WP_101894303   4 NKSKIIYTLTDEAPALATYSLLPIVNHFTSAADIEVETSDLSLAGRILASFPERLTDDQKVTDTLKEMGELTQEPTANII 83 
5Z16_A        90 KLPNISASVAQLTACIKELQSKGYAIPDYPENPATEEEKTIKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHPHS 169
YP_002343962  79 KTPNISASIPQLKAAIKELQDKGYMLPNYPDEPKNDEELQIKTKYQKVLGSAVNPVLRQGNSDRRSTKAVKDYAKNNPYR 158
WP_011397042  83 KLPNISASIPQLKATIKELQQQGFNVPNYPEEAVTEEEKKIEQTYTKVLGSAVNPVLREGNSDRRAPAAVKQYARKHPHK 162
WP_041654413  84 KLPNISASIPQLRAAIKELNEQGYKVPEYKEHPETDEEKEIHARYSKVLGSAVNPVLREGNSDRRAPAAVKAFARKYPHT 163
WP_015045990  84 KLPNISASIPQLKAAIKELQSQGYGLPDYPDSPANEKEQDIKARYAKVLGSAVNPVLREGNSDRRAPRAVKEYARANPHS 163
WP_020915457  84 KLPNISASLPQLINVISELQLHGYKIPNFPENPKTEKEKLIKIKYSQLLGSVVNPILREGNSDRRIPVFIKNHARKNPYY 163
WP_062479996  84 KLPNISASIPQLNAAIKELRNKGFMVPVYPAEPKDDKEKEIKDRYSKVLGSAVNPVLREGNSDRRAPTAVKNYAKKHPHS 163
WP_085759980  83 KLPNISASIPQLKAAIAELQAQGFAVPDYPEDPQTDEDKAIKARYANVLGSAVNPVLREGNSDRRAPPSVKQFAKTNPHK 162
WP_087464161  84 KLPNISASIPQLKAAIAELQSQGFDIPDYPEDPQNDQEADIKDRYSKVLGSAVNPVLRQGNSDRRAPAAVKAYARKHPHS 163
WP_101894303  84 KLPNISASIPQLAAAIAELQEKGYDIPDYPNDPLNPEEVDIKERYAKVLGSAVNPVLREGNSDRRAPAAVKRYARNNPHW 163
5Z16_A       170 MSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRPRNVKMELITNSGKSIVLKPKVALQEGEIIDSMFMSKKALCDFYEKQLD 249
YP_002343962 159 VVEFNPNSKTRVSYMKEGDFFSNEKAVLIDQDCVANIEFTSVDGKKEILKEGLKLEKNEILDATFMDVQKLQEFYAKEIK 238
WP_011397042 163 MGKWSQASRTHVAHMREGDFHATEKSVIIDRPMVARIEFVGKDGAVE-LKRELKLQKDEILDSMRLSVRELCKFLEQEME 241
WP_041654413 164 MGEWSPASRTHVAHMRGGDFYSSEQSVTLDKATNARIVFENKKGEQTVLKSDLPLQEGEVLDGMFMSKKALVKFFEDAIA 243
WP_015045990 164 MGKWSQASRTHVAHMREGDFYASDISTTMTQADSLKIELVEEGGKTTLLKE-VPVQDKEVVSAQFMSTKALRKFLDEEME 242
WP_020915457 164 IKKWSSTSKTHVSYMTKGDFYDNEKSITLNKSCNIRMELLCHNKKILILNKKIPLLKDEILDSSFLSKELLCDFYENQIK 243
WP_062479996 164 MGKWSQASRSHVAHMRGGDFYSGEKSLTVDKAGYVRIEFTDKNGQVTVLKPRVDLLEGEVIDGMFMSKKALCRFFEEQIE 243
WP_085759980 163 MGAWSQASRTHVAHMRGGDFYSSEQSTVIESPCDVRIEIVNKAGETTVLKEKTSLLAGEIIDGMFMSKKALCQFFEEQIE 242
WP_087464161 164 MGPWSQASQTHVAHMRHGDFYSSEQSTVVEKEGDVRIEFVAENGDIRVLKEKTHVLAGEVIDSMRMKAQALRDFFEDQLN 243
WP_101894303 164 MGKWSQASRTHVAHMRAGDFYNSDISTTLKKADTLRIELVDESGKVSVLKE-VKVQDKEIVSAQFMSTKALCKFLNEEMD 242
5Z16_A       250 DCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMAGLYEKIETLPTSLREEIIEDLHA 329
YP_002343962 239 ASKDDDVLFSLHLKATMMKVSDPILFGYAVKVFFKELFIEFQDEFEKLGINPNNGLSELLSKIEN--SSKKDEILKKYSE 316
WP_011397042 242 GARRVGILLSLHVKATMMKVSHPIVFGHAVKVFFKDVFKKHAETFKELGVEPNNGMGNVYEKIQQLPMSKREEIEKDILN 321
WP_041654413 244 DCENTGVMFSLHVKATMMKISHPIVFGHAVKVFYKELFDKYGELFQEIGVNPNNGLSSVIEKIKQLPESKQEQIQEDLHA 323
WP_015045990 243 GARNAGLLFSLHMKATMMKVSDPIVFGHAVEVYFKHAWKKHEKTLKELGVNPNDGLGAVLQKIDSLGYSKRSEIEYDLRK 322
WP_020915457 244 HAYENNLLLSLHLKCTMMKKSDPIIFGYAIKTFYKNVFIKHKKIFKKLNINVNNGLSNLLNKIKILPKNKYEEIIYDIKK 323
WP_062479996 244 DAKETGVLFSLHVKATMMKVSHPIVFGHCVKVFYKELFDKYADLFEELGVNPNDGLGSVYDKIESLPESQRSEIQKDINA 323
WP_085759980 243 DAKNTDVLFSLHVKATMMKVSHPIVFGHAVKVYYKDLFEKHADTFAKLGVNANSGLGNVYEKIEQLPSSKRTEIERDIQA 322
WP_087464161 244 DAKNTNLLFSLHVKATMMKVSHPIVFGHCVTVFYKDLFEKHAETFEELGVDPKNGLSNVYQKIEQLPFSKRSEVEEDILA 323
WP_101894303 243 GARNAGLLFSLHLKATMMKVSDPIVFGHAVRVYFKDAFEKHADTLEELGVEPNDGLGSVLRAVDNLPYSKRSDIEYDFRK 322
5Z16_A       330 CQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNFDP 409
YP_002343962 317 ILAKSADISMVNSDKGITNLHVPSDVIVDASMPAMLKNGARLWDKEGKEKDTNAVIPDQTYATIYEAVIEDLHKNGTLNP 396
WP_011397042 322 CFEHRPELAMVNSDKGISNLHVPSDVIVDASMPAMIREGGKMWGADGKLKDTKAVIPDSNYATIYQEVINFCKHHDAFDP 401
WP_041654413 324 CYEHRPEIAMVDSVKGITNLHVPSDVIVDASMPAMIRNSGKMWARDGKLKDTKAVMPESTYATIYQEVINFCKTHGAFDP 403
WP_015045990 323 CYEARPMLAMVDSDKGITNLHVPSDIIVDASMPAMIRAGGKMWSSDGKLQDTKAVIPDSCYATIYQEVLNFCKHHDAFDP 402
WP_020915457 324 CDINRPSFAMVDIKKGISNLHAPNYIIIDSSMPTMIRNGGKMLDKIGNEKETKAIIPDSTFAKIYQEIINFCKKNN-LDP 402
WP_062479996 324 VYANRPPIAMVNSDKGISNLHVPSDVIVDASMPAMIRSSGQMWGPDGKLHDTKAVIPESTYATIYQEVINFCKTHGAFDP 403
WP_085759980 323 CYLDRPAMAMVNSDKGISNLHVPSDVIVDASMPAMIRESGKMWGPDGKLHDTKAVIPESTYARFYQEMINFCKTHGAFDP 402
WP_087464161 324 CYQNRPEIAMVNSDKGISNLHVPSDVIVDASMPAMIRNSGKMWGPDGKLKDTKAVIPDSTYATIYQEVINFCKHNGAFDP 403
WP_101894303 323 CYEKRPMMAMVDSDKGITNLHVPSDIIVDASMPAMIRNGGKMWSADGKLQDTKAIIPDTCYATIYQEVINFCKHHDNFDP 402
5Z16_A       410 KTMGTVPNVGLMAQKAEEYGSHDKTFEIPEAGIANITDlDTGEVLLTQ-NVEEGDIWRMCQVKDAPIRDWVKLAVTRARN 488
YP_002343962 397 SKLGSVSNVGLMAKKAQEYGSHDKTFVAKEEGTFKIVS--NGKVLLEH-KVRKGDIYRANQAKFDAVLNWIDLGIERSEL 473
WP_011397042 402 TTMGTVPNVGLMAQKAEEYGSHDKTYELDADGVMRIVD-DQGNVLMQH-EVEKGDIWRACQTKDLPVRDWVKLAVTRARL 479
WP_041654413 404 TTMGTVPNVGLMAQKAEEYGSHDKTFEMKEDGVVRVVA-EDGTVLTEH-KVEEGDIWRACQTKDLPIRDWVKLAVNRSRS 481
WP_015045990 403 RTMGTVPNVGLMAQKAEEYGSHDKTFVIPADGTVRVVN-KAGEVVLQHdKVEQGDVWRMFTAKDAPIQDWVKLAVNRSRL 481
WP_020915457 403 SIMGTVQNIGLMAQKSEEYGSHDKTFEIPYDGIARIVDvYNNNILIEH-HVKKGDIWRVCQTKDESIKNWIMLAINRSKQ 481
WP_062479996 404 TTMGTVPNVGLMAQKAEEYGSHDKTFEMKADGVVRIID-QDDKVLMEH-NVEEGDIWRMCQAKDAPIRDWVKLAVTRARH 481
WP_085759980 403 TTMGTVPNVGLMAKKAEEYGSHDKTFELPFDGTVRIVD-NNDTVLMQH-ECEEGDIWRMCQAKDGPIQDWIKLAVNRARA 480
WP_087464161 404 TTMGTVPNVGLMAQKAEEYGSHDKTFELEGTGVVRVVD-EAGTVLMQH-DVEKGDIWRMCQTKDAPIRDWVKLAVNRARA 481
WP_101894303 403 RTMGTVPNVGLMAQKAEEYGSHDKTVELPCNGTMRIVN-SAGEVLLQHeNLEAGDVWRMFQAKDAPIQDWVKLAVTRARA 481
5Z16_A       489 SGMPAIFWLDPYRPHENELIKKVQKYLKDHDTTGL-DIQIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIME 567
YP_002343962 474 SGAEAIFWLDSKRASNKIMITLVQNRLKE---KGK-NVAILTPKEACLRSLELIREGKDVISITGNVLRDYLTDLFPILE 549
WP_011397042 480 SGMPAIFWLDEDRPHDMNLKTKVVEYLKVHDTDGL-DIHIMGYDVAMRTTLERLRRGKDTISVTGNVLRDYLTDLFPILE 558
WP_041654413 482 SGMPAVFWLDDERAHDAQLIKKVKTYLADLDTEGL-DIRIMSPVRAIRWTMERLIRGLDTISVTGNVLRDYLTDLFPILE 560
WP_015045990 482 SGMPAVFWLDPKRGHDRQMIQKVQTYLKDHDLTGL-DIQILPPEAAVRLTMERMKEGKDTISVTGNVLRDYLTDLFPILE 560
WP_020915457 482 TNIPTIFWLDTQRPHEFEIIKKIEFFLKECNVKDIkNIKIMSKIDAMNYTLKRLINGKDTISVTGNVLRDYLTDLFPILE 561
WP_062479996 482 SGMPAIFWLDDERAHDAQLIEKVITYLKDHDTEGL-DIQIMSPVRAIRYTMERCIRGLDTISVTGNVLRDYLTDLFPILE 560
WP_085759980 481 TDTPAVFWLDTARAHDVQLIKKVEQYLPDHNTEGL-VIKIMDPVSAIRYTMERLIRGEDTISVTGNVLRDYLTDLFPIME 559
WP_087464161 482 TGSPAVFWLDPKRAHDTQLIHKVTEYLKEHDTDGL-DIQIMSPVNAIRFTMERLKDGEDTISVTGNVLRDYLTDLFPILE 560
WP_101894303 482 SKMPAVFWLDEYRGHDREMIKKVEHYLQYHDTEGL-KIRVLNPDMAMRYTLERLLRGKDTISVTGNVLRDYLTDLFPILE 560
5Z16_A       568 LGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEEMGIKENNARTKLLAKTLDEATG 647
YP_002343962 550 LGTSAKMLSVVPMLNGGAMFETGAGGSAPKQVEQLVEENHLRWDSLGEFLALQASLEFYANKCGNHKAKVLAECLDEAIG 629
WP_011397042 559 LGTSAKMLSVVPLMAGGGLFETGAGGSAPKHVQQFAEENHLRWDSLGEFLALAVSFEDIAVKTGNKKAEILAKTLDKATE 638
WP_041654413 561 LGTSAKMLSIVPLLNGGGLYETGAGGSAPKHVQQLIQENHLRWDSLGEFLATAVSLDELGEKQNNERARLLGQTMDKATE 640
WP_015045990 561 LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFAEENHLRWDSLGEFLALAVSFEDVANKTGNKKAKVLADALDAATG 640
WP_020915457 562 LGTSSKMLSIIPLLSGGNLFETGSGGSAPKHIEQFLIENHLRWNSLGEFLALLSSLECLFIKTNNKKANILSKTLEIAIN 641
WP_062479996 561 LGTSAKMLSIVPLMAGGGLFETGAGGSAPKHVQQFVEEGHLRWDSLGEFLALAVSFEDLAIKQGNGKAKVLATALDKATE 640
WP_085759980 560 LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFEEEGHLRWDSLGEFLALAVSLEDLADKTDNAKAKVLAKTLDAATA 639
WP_087464161 561 LGTSAKMLSVVPMMAGGGMYETGAGGSAPKHVQQFVEEAHLRWDSLGEFLALAVSLEDLGNKTGNNRAKILAKTLDQAIE 640
WP_101894303 561 LGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVQQFVEENHLRWDSLGEFLALAVSIEEVAKKSNNPKAQILATALDDAIE 640
5Z16_A       648 KLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQNEDAELKAKFAPLAKALAENEQKIVAELAQVQGKPADIGGYYAV 727
YP_002343962 630 EWLENNKAPSRKVKEDDNRTSHFYLAMYFANHLARQASDMELQSFFKDIALELSSNEEKIRAEFNDAQGVKVDLGGYYKF 709
WP_011397042 639 KLLMNGKSPSRKVGELDNRGSHYYLAMYWAEAVAAQTDDAELAAQFAPLAKELAANEDKIVSELLAKEGTPVEMGGYYHA 718
WP_041654413 641 RLLENNQSPSRVTGELDNRGSHFHLARYWAEELSKQDEDKELKEFFTKLSAQLEENKDKILEEMTVVQGHPADIGGYYHP 720
WP_015045990 641 KLLANDKSPSRKVRELDNRGSHFYLAMYWAEALAAQTEDADLAKAFAPLAKDMAAKEEAILKELADCQGVPVDMGGYFYP 720
WP_020915457 642 KLLDYNKLPSPIVNELDTRESQFYLTIYWAQALATQKLDKDLNYFFTPFFNSLLNNQKKIIKEFQYIQGKPVNIGGYFMP 721
WP_062479996 641 TLLNEGKSPLRKAGELDNRGEHFYLAMFWADEVAKQTEDAEMAALFKPLADKLRENEQQILTEIDATQGKPADIGGYYYP 720
WP_085759980 640 KLLQNNKSPSRKVGELDNRGSHFYLAMYWAEALAAQTEDTQLQASFAALSANLLDNESAIIDELNAVQGAAIELGGYYRP 719
WP_087464161 641 KLLDNDKSPSRKVGEIDNRGSHFYLALYWAKFLGSQSEDTELQTIFSGLAQSISENRSKIIEELSAAQGRPMDIGGYYHP 720
WP_101894303 641 KLLENGKSPSRTVNELDNRGTHFYLAKYWAEALSVQSHDAELKTHFTKLAKALADNEEAIVTELTNCQGVSVDMGGYYLP 720
5Z16_A       728 DPAKVSAVMRPSATFNAALSTV 749
YP_002343962 710 DDEKANKIMRPSATFNAILEKI 731
WP_011397042 719 DPKLVSKAMRPSDTLNALIDG- 739
WP_041654413 721 PMEKVCEVMQPSATFNKILAEA 742
WP_015045990 721 DAKKLEQAMRPSQTLNQLLGNI 742
WP_020915457 722 INKLINHAMRPSKTFNKLLNLI 743
WP_062479996 721 DEEKTRKAMFPSETFNNILAEL 742
WP_085759980 720 DDALAEKAMRPSATFNSALDSI 741
WP_087464161 721 DIEKVTGAMRPSETFNTILANL 742
WP_101894303 721 ELEKVEKLMRPSETLNALIGG- 741
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