4DB3,2AP1,7P7W


Conserved Protein Domain Family
ASKHA_NBD_ROK_NAGK
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cd24057: ASKHA_NBD_ROK_NAGK 
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins
NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Links
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Statistics
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PSSM-Id: 466907
Aligned: 27 rows
Threshold Bit Score: 281.814
Created: 14-Dec-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:DClick to see conserved feature residue pattern help
Evidence:
  • Comment:the catalytic Asp acts as a catalytic base.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
4DB3_A        25 MYYGFDVGGTKIEFGAFNEklERVATERVPTPtddYPLLLETIAGLVAKYDqef-aceGKIGLGLPGMEDaDDATVLTVN 103 Vibrio vulnificus
7P7W_AAA     116 MYYGFDIGGTKIEFGAFDAdlVRVARERVATPtesYAAFLDAIVTLVNNADaef-gvkGTVGIGIPGIADvETGKLLTSN 194 synthetic const...
WP_010102986   1 MWGAIDLGGTKIEACLYDAqlQPVQRQRVATPqgaYAGLLDAIEQQCLWLQgcagdahLPIGMGIPGLIDrQTGLSTTAN 80  Verminephrobact...
A0KYQ6         1 MYYGLDIGGTKIELAIFDTqlALQDKWRLSTPgqdYSAFMATLAEQIEKADqqc-gerGTVGIALPGVVK-ADGTVISSN 78  Shewanella sp. ...
PHQ95163       3 NAGGIDVGGTKIEATLFDAnwQVLETRRIPTPtdsYNNLLAEILAQYHWLEsisdsanTPIGIGVPGIVDrTTGHMVIAN 82  Marinosulfonomo...
PRD20981       2 AVYGLDIGGTKIETAIFNNnlEQQQSWRITTPtddYQQFLQAIYQQVLKADelt-ssqGAVGIGMPGIIN-EAGKVLSAN 79  Trichonephila c...
WP_150445334   2 IAAGIDLGGSKIETRLFDEewQLAHSRRRATPg-dYGALLTALLEELRWIFetg--gkVPVGLGTAGLLDpVSGHMIAAN 78  Histidinibacter...
WP_110149584   1 MITSFDIGGSTIKAAIATStrDITPFGRVPTPrddFSAFAAAIASLIASGGap---erSPIAISITGVVDpASGHVTCAN 77  Nostoc sp. 3335mG
TQK11553       5 MITSFDIGGTAIKSAVATAdgQIGAAHRVPTPthdFAAFAAAMQALIDAGGp-----tEGVAISIAGVIDpDSGRIKCAN 79  Herbaspirillum ...
WP_125655893   1 MRLCADVGGSFVDIAAFDErgAIGWRAKRPTPvgdWAAFVALFADALRAVPc------ARVSIATAGLVDpANGIVTTAN 74  

Feature 1                                 #                                                      
4DB3_A       104 VPAAkGKPLRADLEAKiGRSVKIENDANCFALSEAWdeelqdaPSVMGLILGTGFGGGLIYEGKVFSGrnNVAGELGHMR 183 Vibrio vulnificus
7P7W_AAA     195 IPAAmGHTLQRDLEERlQRPVKIENDANCFALSEAWdedlrgePSVLGLILGTGVGGGLIFNGKVHSGraNIAGEIGHTR 274 synthetic const...
WP_010102986  81 LSAM-GQPLQADLSARlGRPIAVENDCKCFALSEAQggagagqALVFGLILGTGVGGGLCRQGELMLHhlGISGEVGHVA 159 Verminephrobact...
A0KYQ6        79 VPCLnQRRVAHDLAQLlNRTVAIGNDCRCFALSEAVlgvgrgySRVLGMILGTGTGGGLCIDGKLYLGanRLAGEFGHQG 158 Shewanella sp. ...
PHQ95163      83 LPVA-RQNLRDDLIREvNHPVPFVNDCRAFTLSEAKlgagrghSVVLGLILGTGVAGGLAVNTRLIYGknGAAGEFGHTP 161 Marinosulfonomo...
PRD20981      80 VPCAtGKVIADDLQALlKRPVAILNDTRCFALSEANggagegySRVFGAIVGTGAAGGMCIDGTLFNQglGMSGEYGHLP 159 Trichonephila c...
WP_150445334  79 LPIS-GRNLLSDLDES-WGPVSLVNDAQAFALSEAAfgaargaKSAAGVILGTGVSAGFIGGDRLAGGysAASGEVGHLA 156 Histidinibacter...
WP_110149584  78 IPCVdGRHLAKDLSVAlGRPVSVANDADCFVLAEATagagrghRVVFGAILGTGVGGGIVVDGMLHPGagGLGGEWGHGT 157 Nostoc sp. 3335mG
TQK11553      80 IPGIdGRTLAADLSAAfGLPVWILNDADSFALAEARagagrghRNVFGLILGTGVGGGLVIDGHLVGGpgGLAGEWGHGP 159 Herbaspirillum ...
WP_125655893  75 IACIhGRTLADDLAAAlGIPVRVVNDADAFVLAEATlgvaqghDRVFGIILGTGVGGGLVEHGRIVGGrgGLGGEWGHGP 154 

Feature 1                                                                                        
4DB3_A       184 Lpldawf-hlgdnAPLLGCGCGKKGCLDSYlsGRGFELLYAHYygeekkAIDIIKANAAgdEKAAEHVERFMELLAICFG 262 Vibrio vulnificus
7P7W_AAA     275 LpydalkllgmenAPIFPCGCKNSGCIDNYlsGRGFEQLYDHYfseklsAPEIIAHYEQgeRRAVQHVERFMELLAICLA 354 synthetic const...
WP_010102986 160 Lpvhct---eqwrLPVLRCGCGRTGCYETYvsGPGMARLCQHLtgralgAQDIAQGHARgdAQLQTVYRVWLWLLCELLH 236 Verminephrobact...
A0KYQ6       159 Vsanva---crhqLPLYVCGCGLEGCAETYvsGTGLGRLYQDIagqtadTFAWLNALRCndPLAIKTFDTYMDILGSLMA 235 Shewanella sp. ...
PHQ95163     162 Vpatls---rkfsLPILTCGCGQTGCYETLisGPGMVNLAANLfdltktPPEIASAAAGgdEIAGQIMDIWTEITCGLIQ 238 Marinosulfonomo...
PRD20981     160 Lsaylq---qkyqLPVLKCGCGLNGCVESYiaGPGVQTLYQHItqspksAIEWANDIKLgdEQALKVLACYLDILGETFA 236 Trichonephila c...
WP_150445334 157 Apahlv---gqfdLPVHACGCGRTGCVETYisGPGLAGLARHMtgtelsSETIGKRRAE--PALAPIWSLWCALTAEMLM 231 Histidinibacter...
WP_110149584 158 Ivatrvs-vppydLPHFACGCGLSGCLDTVgaARGLERLHRHLhgaelaSTEIVAAWEAgdAEAGRTVDLLAELVAPPLA 236 Nostoc sp. 3335mG
TQK11553     160 Vaaqfag-tppqaIPRFPCGCGQTGCLDTVggARGLERLHGALgqpgldSRAIIDAWQAgdAAAERTVAVFIDLLAGPLA 238 Herbaspirillum ...
WP_125655893 155 Vvqssr--vapdaMPVFACGCGRRGCLDTIgsARGIERLHAFLhghpadSIAITRGAAAgePRAVATVDYWCDLVGGPLA 232 

Feature 1                                                                     
4DB3_A       263 NIFTANdPHVVALGGGLSNFELIYEEMpkRVPKYLLSVAKCPKIIKAKHGDsGGVRGAAFL 323 Vibrio vulnificus
7P7W_AAA     355 NIFTCLdPHVVVLGGGLSNFELIYQELpkRLPAHLLHVAKLPKIIKARHGDaGGVRGAAFL 415 synthetic construct
WP_010102986 237 TMQLAIdPDCVVFGGGLSRIPGLPEQVaqAFPAHQLPGLRAPRFASAQFGDsSGVRGAAIL 297 Verminephrobacter aporrectodeae
A0KYQ6       236 SLVLAMdPDIIVLGGGLSEVEEILAALpqATKAHLFDGVTLPQFKLADFGSaSGVRGAALL 296 Shewanella sp. ANA-3
PHQ95163     239 SIILVVdPDCIVLGGGLSNIPEITDRLigQLPIGLLSGVKIPQILLAEGGDsSGVRGAAMV 299 Marinosulfonomonas sp.
PRD20981     237 AISKSLhPEVIVLGGGLSLIDAIVEKLpdAIQTHLFSGFAVPDVKRAKFGDsSGVRGAAII 297 Trichonephila clavipes
WP_150445334 232 GLVCTVdPEVIVLGGGLSRIVDVERDLgaALSRAQIAGLRTPEIRIAEGGDaSGARGAALA 292 Histidinibacterium aquaticum
WP_110149584 237 LVVNIVgPDIIPVGGGLGNSRALIQRLdaAVRPRILRRLDRPLVVPAELTAdAGLIGAAAL 297 Nostoc sp. 3335mG
TQK11553     239 MLVNTVgASILPVGGGLSNSAPLIARLdaAVRAAILRKTDTPIIVPGQSGAeAGLIGAAWL 299 Herbaspirillum sp. SJZ107
WP_125655893 233 MLLHALsATIVPVGGGLANAGGLIAALdaRVRANLLAPTTTPIVVPGRLGEdAGLIGAFVA 293

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