1RJB,1T46,3EYG,3RHX,1FPU,3BKB,1JPA,2XB7,2IVS,3CC6,3GEN,1JQH,2OO8,3PLS,3IKA,1U46,1SM2,1BYG,1U59,2W1I,3NYX,3DTC


Conserved Protein Domain Family
TyrKc

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smart00219: TyrKc 
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Tyrosine kinase, catalytic domain
Phosphotransferases. Tyrosine-specific kinase subfamily.
Statistics
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PSSM-Id: 197581
Aligned: 108 rows
Threshold Bit Score: 281.342
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RJB_A         47 LEFGKVLGSGAFGKVMNATAYGISKTgVSIQVAVKMLKEK---ADS---S-------EREALMSELKMMTQLgSHENIVN 113  human
NP_494994     138 IKLGKMLGEGAFGGVYKAAFYCKG---EKRMVAVKVNKGNekiSTR---A-------MIEDVCKEARIMRQY-QHPNVVC 203  nematode
XP_002721714   39 LTLEEIIGIGGFGKVYRAFWI-------GDEVAVKAARHD---PDEdi-------sqTIENVRQEAKLFAML-KHPNIIA 100  rabbit
NP_501993     175 INLDKKLGCGAFGEVFKGQYKAVgsTnPPIEVAVKRILGN---AKRk----------QIQEFCNEAQIMTVL-QHENIVA 240  nematode
AAA34002      156 LFFGLKFAHGAHSRLYHGVYK-------DEAVAVKIIMVP---EDD---GngalasrLEKQFIREVTLLSRL-HHQNVIK 221  soybean
T26078        102 IHLENILGNGAFGEVLKARYIPRg-HtNGVEVAVKRALGT---AQR---Dq-------MQEFCHEAQIMGTL-KHDNVVK 166  nematode
NP_492594     195 INLGKKLGNGEFGEVFQGVLSVGIFt-NDVEVAVKTMKGS---KVT---Ad------ERITFLREANLMLKL-NHKYVVR 260  nematode
NP_496201     120 VIFQKKIGAGAYGTVYRGKLVKT-----DEVIAVKKLDPE---GADe---------dGLAEMMKEARVMQLY-DHPNIVK 181  nematode
NP_001040963  153 YDDTGKLGSGNFCIVYRGMLRKQGK---IIPVAIKVSKNS---DKE---Saal--meTRNLLLAEARIMMNY-NNINVIR 220  nematode
3DTC_A          9 LTLEEIIGIGGFGKVYRAFWIG-------DEVAVKAARHD---PDEdisQ-------TIENVRQEAKLFAML-KHPNIIA 70   human
1RJB_A        114 LLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKfsedeieyenqkrleeeedlnvLTFEDLLCFAYQVAKGMEFLEFK-- 191  human
NP_494994     204 FFGVCVEKEPIMLVMELASQGALDSFLKNEKNN----------------------VSLRDKLKYSFDASKGLEYLHQH-- 259  nematode
XP_002721714  101 LRGVCLKEPNLCLVMEFARGGPLNRVLSGKR------------------------IPPDILVNWAVQIARGMNYLHDEai 156  rabbit
NP_501993     241 FYGFASLEEPIMVVMELVTGGDLRKYLQTTQN-----------------------IPKLQILWFAMNVASGMRHLSSK-- 295  nematode
AAA34002      222 FSAACRKPPVYCIITEYLAEGSLRAYLHKLEHQt---------------------ISLQKLIAFALDIARGMEYIHSQ-- 278  soybean
T26078        167 LYGIASLEQPIMLVMELITGGDLKKYLQSTPS-----------------------IPNRQLIAFALDIANGMRHLVIK-- 221  nematode
NP_492594     261 LYGVATQQEPIMIVMELCSGGCLKSRIEKKDEQ----------------------LSDVLKRKYCKQIAKGMRYLEKK-- 316  nematode
NP_496201     182 FHGFILDDLPYLLVLEYCNGGAVEDRLRDKGEK----------------------IKVPTRVKYTYMAACGMDYLHKK-- 237  nematode
NP_001040963  221 IYGVACDVPPFMVCMEFCSGGSLEDALKKYGKD----------------------MEEFERQILLIDAARGMRYLHDK-- 276  nematode
3DTC_A         71 LRGVCLKEPNLCLVMEFARGGPLNRVL--SGKR----------------------IPPDILVNWAVQIARGMNYLHDEai 126  human
1RJB_A        192 -SCVHRDLAARNVLV--------THGK--------VVKICDFGLARDIMS--D-SNYVVR-GnAR-LPVKWMAPESL-FE 248  human
NP_494994     260 -GCIHRDVAARNFLM--------HKN---------VVKITDFGLSKQLSDlaH-KYKLKDiQ-AK-LPIRWLAPEVI-VT 317  nematode
XP_002721714  157 vPIIHRDLKSSNILI--------LQKVengdlsnkILKITDFGLAREWHR--T--TKMs--A-A--GTYAWMAPEVI-RA 218  rabbit
NP_501993     296 -GIIHRDLAARNCLV--------TQDL--------KAKISDFGLSLQGTE--V-TTKNL----EK-APIRWLAPESL-KS 349  nematode
AAA34002      279 -GVIHRDLKPENILI--------NEDN--------HLKIADFGIACEEAS--C-DLLAD----DP-GTYRWMAPEMI-KR 332  soybean
T26078        222 -KVIHRDLAARNCLI--------SRPTl-------QVKISDFGLAVQATE--V--IVKK--L-GK-APTRWLAPETF-QK 276  nematode
NP_492594     317 -QVIHRDLAARNVLL--------DKSD--------NCKISDFGLSLFGKL--HkEQK------LMkVPIRWLAPETL-LK 370  nematode
NP_496201     238 -NCIHRDIASRNCLI--------HKGV---------VKMADFGMCRAQSV--Y-KVDL-----KKpCNIRWLAPEVW-DN 290  nematode
NP_001040963  277 -KCVHRDLASRNCLI--------SFDG--------IVKIADFGLSKTLEK--DqKAFKEA---LKeAPLAWLAPECIqRE 334  nematode
3DTC_A        127 vPIIHRDLKSSNILIlqkvengdLSNK--------ILKITDFGLAREWHR--T-TKMSAA-G-A----YAWMAPEVI-RA 188  human
1RJB_A        249 GIYTIKSDVWSYGILLWEIFSLGVNPYPG-IPvDANFYKLI-QNGFKMDQPFY----ATEEIYIIM-QSCWAFDSRKRPS 321  human
NP_494994     318 ATYTFKSDVYSFGILLWEIFMDGAIPYPG-MK-LAEVKQKV-KNGYRMDAPDR----MPAFVRNIMiSQCWPQNPEDRGN 390  nematode
XP_002721714  219 SMFSKGSDVWSYGVLLWELLTGEVPFRGI-DG-LAVAYGVA-MNKLALPIPST----CPEPFAKLM-EDCWNPDPHSRPS 290  rabbit
NP_501993     350 GMFNEKTDVWSYGVFLTELMARCEHDPLYpKS-LKDAKAWI-LTEERPHKMENg---DPKELMVLI-DACCERNPNERLN 423  nematode
AAA34002      333 KSYGKKVDVYSFGLILWEMLTGTIPYED--MN-PIQAAFAV-VNKNSRPIIPSn---CPPAMRALI-EQCWSLQPDKRPE 404  soybean
T26078        277 GIFNEKTDVWSFGVVLTEILTRCAADP---LA-PRTLEECK-KYIIESPHPHRienkePKELADLV-EMCCDKNTICRAN 350  nematode
NP_492594     371 GIYSSKSDVWSFGVVMFEVFSGEYPYADv-KV-LKELRRKV-AHENLRLKPPSd---MPTDDAKVM-EMCFEP-VDNRAT 442  nematode
NP_496201     291 GETRFNTDVYAFGIMMWEFFETPFKSPYVeMK-AAQVKRKT-RAGYRLPPPPS----MPSRMVEIM-SECWQVDAEKRPT 363  nematode
NP_001040963  335 SEFSTKTDVWAFGVVIFEVYNNAEKLFAGe-E-DIAILRKI-KKANMPTIENRt---KVPAMQAVL-SSIWTRKPDDRPE 407  nematode
3DTC_A        189 SMFSKGSDVWSYGVLLWELLT-GEVPFRG-ID-GLAVAYGVaMNKLALPIPST----CPEPFAKLM-EDCWNPDPHSRPS 260  human
1RJB_A        322 FPNLTSFL 329  human
NP_494994     391 MNEIRLAM 398  nematode
XP_002721714  291 FTNILDQL 298  rabbit
NP_501993     424 FNTVKRQI 431  nematode
AAA34002      405 FWQVVKIL 412  soybean
T26078        351 FQNAKRRL 358  nematode
NP_492594     443 FVQVCNRY 450  nematode
NP_496201     364 AEELKEKL 371  nematode
NP_001040963  408 MQKVLEKL 415  nematode
3DTC_A        261 FTNILDQL 268  human
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