Conserved Protein Domain Family
FctA

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pfam12892: FctA 
Spy0128-like isopeptide containing domain
The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonization of human tissues. Members of this family have a conserved N-terminal lysine and C-terminal asparagine that can form a covalent isopeptide bond.
Statistics
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PSSM-Id: 463742
Aligned: 104 rows
Threshold Bit Score: 42.0031
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
kribb:BLA_0249 2281 VPMTKTIagrdl---kdgeFEFA-LTKAD----------------------------Gtlvgtak--------------- 2313
jgi:Xcel_0148  1454 VDVLKVLtgrel---rlneFEFR-VSPENaasaarlnispegktvasgerpdepaltT---------------------- 1507
CCY26148        862 IRGTKTLtgdtl---akdqFSFA-LTKAEkvgsegatvplpvidenslevgntvkntEata------------------- 918 
CDC54989         38 AGVTKNLhiaegitvpdttFTFN-ITQTAgdattvtktttaafkadtvtndlvskaaTt--------------------- 95  
jgi:Shel_00430   46 AAVTKVLhsnegs-tvtatFSFT-ATGTTvaiddegtvseptdglgvtiasvelttaGdgedvs---------------- 107 
CDA15080         63 AQITKELklaegitipratFHFT-ADKite-------------------------daPkaeiesvsysaedlkgdlsegv 116 
WP_155236496   1652 LKVTKELtgrkw--ldtdtFSYT-LTA-AdeatveaiengfitlpenaggleitkasAgh-------------------- 1707 [Ruminococc...
WP_012289938   2919 LKISKNVlnltds-iknkeYSFK-ISLTKdn------------------------------------------------- 2947 Finegoldia ...
SCH28518       2932 IEASKKLtgrdm---kaneFRFEiVTRAAenpegfketfaaag---------------------------------tnte 2975 uncultured ...
WP_155236496   2100 LQITKALngrdm---ekdqFTFT-VTPKAtegsttaeeaaekfglanaantykneaaEagavttin-------------- 2161 [Ruminococc...
kribb:BLA_0249 2314 --naadgsvKLpav----------------------tfDAPG---N-YAYLVREnaad------adngV-T--------- 2349
jgi:Xcel_0148  1508 ---------VLgpvt--------------------fdqDDLG---EhFTFNVSEvkgs-------apgV-Tyddraytvi 1547
CCY26148        919 ------nniFFgtit--------------------ydvQDAGt----YKYYFQEvvped-----eepgM-V--------- 953 
CDC54989         96 ---------ELada---------------------tkyPHAGv----YTFTVNEvkgd-------vagM-T--------- 124 
jgi:Shel_00430  108 ----gtgkiTFpa------------------------yTHAGv----YAYMIEEaqqativnddgsegTmT--------- 146 
CDA15080        117 ykinkagtiTFge------------------------fPHAG---E-YQYHVQEtadtyh--tasgegM-T--------- 156 
WP_155236496   1708 -------qaAFgdi----------------------qfTIAG---T-FKFNVTEqpsg-------iagI-T--------- 1737 [Ruminococc...
WP_012289938   2948 -------------------------------------kPLAG------EYNAQSsn-----------gL-Tqvvkngatl 2972 Finegoldia ...
SCH28518       2976 aaegaegavKFagndgaltyttesldqavkdgyavkseNDDGsdvWtVSYTAREitdk------lpggV-T--------- 3039 uncultured ...
WP_155236496   2162 --vldgknvTFt-------------------------qADAG---KtFTYEAAEtag--------tntAyT--------- 2194 [Ruminococc...
kribb:BLA_0249 2350 ----YD-N--RTY--A---VVAQVTdkgdgtlavqwq-----------------iadsdgnavkamAFENTYA 2393
jgi:Xcel_0148  1548 lkpvYDaE--SGEldVlttVTVGLTtttysar---------------------------aaeqpvvTFTNAYA 1591
CCY26148        954 ----YDdE--EKV------VTVTVTydegvlnstvsvd---------------tgdgtaagksaslTFHNVKK 999 
CDC54989        125 ----YD-T--KTY--T---VNVYVVndgdtlkvdsit------------------andgetkvsdmSFDNTYV 167 
jgi:Shel_00430  147 ----YS-T--DKYlmR---VYVENEdtgvaikavtfeknp------------satsngekvdggdvKFENTFV 197 
CDA15080        157 ----YS-T--EAY--T---MHVYVIntenggtevekit----------------asntagdkvsemNFENIYI 201 
WP_155236496   1738 ----DD----QEAerT---VVVKVTdkkngtleaa----------------------vvegesenlTFINTYG 1777 [Ruminococcus] tor...
WP_012289938   2973 tiknNEiLtiEKLpeN---VDVKIEeilpkgfelnsnsv--------------vqtkiikdktselKLVNEYK 3028 Finegoldia magna
SCH28518       3040 ----------AVEgkTsfdFTVVVTdrtdgtlta-----------------------qvqlpeggiVFENAYT 3079 uncultured Ruminoc...
WP_155236496   2195 ----YD-T--DVR--T---VTVKVKdnnnstltvttrvtkvkdgqevivdeqevttgevgqkkatiSFVNTYN 2255 [Ruminococcus] tor...
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