4OBY,1BS2


Conserved Protein Domain Family
argS

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TIGR00456: argS 
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arginyl-tRNA synthetase
This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Statistics
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PSSM-Id: 273085
Aligned: 15 rows
Threshold Bit Score: 559.652
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OBY_A     4 IQALLSEKVRQAMIAAgapa-----dcepQVRQSA-KVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLN-GIASKV 76  Escherichia coli K-12
P56128     1 MHTLIKGILEEILEEE-------------VIVEYPkDREHGHYATPIAFNLAKVFKKSPLAIAEELALKISTHeKTQGLF 67  Helicobacter pylori...
P46906     7 MKDVLKEEIKAAVLKAglaee---sqipnVVLETPkDKTHGDYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGkASIEKL 83  Bacillus subtilis s...
P75222     4 INTDLQECLNALNLEFdeh--------keLVKLVK-NNSFSGFASTVVFHLKGVNQKETAQQIAAWLLKHKKA-HYRRVF 73  Mycoplasma pneumoni...
O27496     5 IEKEARDSITAALEKLgikv-----ppeiKLEEPP-NPQLGDLASTVSFELAGKLRRAPIEITADIMSVIETP-EIFETI 77  Methanothermobacter...
Q57689     3 IKSNIINALKEVISKEicke------idiKLDKTP-NLELGDYSVNICFRLAKELKKNPKIIAEELVDKLKAM-NIEGVK 74  Methanocaldococcus ...
O29368     5 FIEEVIKALGEYGDKK-------------FLRES----EHADLASTIAFKLAKERKKSPKEIADEIVENLEVEsEYIGSV 67  Archaeoglobus fulgi...
O51540     5 VKKKIKDEINVIVTNLalsnnikldniniNIQKPP-KSDLGD-ISILMFEIGKTLKLPIEIISEEIIKNLKTK----YEI 78  Borrelia burgdorfer...
AAB68931  69 PLDVLRLDISKALHDIsgidh---slilnALESTN-SMDRGD--LLLPLP--KIKVADPVAVANRWAIELSTH-GCIGKV 139 baker's yeast
Q05506    31 IVDLMRNYISQELSKIsgvds---slifpALEWTN-TMERGD--LLIPIPRLRIKGANPKDLAVQWAEKFPCG-DFLEKV 103 Saccharomyces cerev...
4OBY_A    77 EIAGPg--FINIFLDPaFLAEHVQQALASDR--LGVATPE--KQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFL 150 Escherichia coli K-12
P56128    68 DSVVAckgYINFTLSL-DFLERFTQKALELKekFGSQVKSerSQKIFLEFVSANPTGPLHIGHARGAVFGDSLAKIARFL 146 Helicobacter pylori...
P46906    84 DIAGPg--FINFYMNN-QYLTKLIPSVLEAGeaYGETNIGn-GERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKA 159 Bacillus subtilis s...
P75222    74 VANNN---FINFEISPqKYLDFLKTKPT-----FAPKPTK-----VLIEWVSANPTGELHLGHVRNAFFGHVLNNLMVFL 140 Mycoplasma pneumoni...
O27496    78 ESKGP---YINFFVDYgRFSSRLLESIQd---dYGSHPPR--DERVILEHTSANPNGPLHIGHIRNAIIGDSLARILRMA 149 Methanothermobacter...
Q57689    75 EIKAVn-gYINFYIDYnKFAKNLMEEIDKKGnnYGRGDKK--SIKIILEHTSANPNGPLHIGHLRNAIIGDCLKRILEFY 151 Methanocaldococcus ...
O29368    68 ESVNG---YINFFASY-EFLEDTVNVILDEDenYGHLNLK--G-EILIEHTSANPDGPLHIGHIRNSIIGDTIARIFAKA 140 Archaeoglobus fulgi...
O51540    79 KAVGP---YLNIKISRkEYINNTIQMVNTQKdtYGTSKYLd-NKKIILEFSSPNTNKPLHVGHLRNDVIGESLSRILKAV 154 Borrelia burgdorfer...
AAB68931 140 CAKGP---FLQFFLDQrYLIQSTVPNILLQKgkYGQKKSRh-QKKVVVEFSSPNIAKPFHAGHLRSTIIGGFLSNLYEAM 215 baker's yeast
Q05506   104 EANGP---FIQFFFNPqFLAKLVIPDILTRKedYGSCKLVe-NKKVIIEFSSPNIAKPFHAGHLRSTIIGGFLANLYEKL 179 Saccharomyces cerev...
4OBY_A   151 GHKVIRANHVGDWGTQFGMLIAWLEKQQQE---NA-GEMELADLEGF-YRDAKKHYDEDEE-------FAERARNYVVKL 218 Escherichia coli K-12
P56128   147 GHEVLCEYYVNDMGSQIRLLGLSVWLAYREhvlKEsVTYPEVFYKGEyIIEIAKKANNDLEp-----sLLKENEETIIEV 221 Helicobacter pylori...
P46906   160 GYDVSREYYINDAGNQINNLALSVEVRYFEalgLE-KPMPEDGYRGEdIIAIGKRLAEEYG-------------DRFVNE 225 Bacillus subtilis s...
P75222   141 GFQTVREYWVNDYGQQARVFGFSVYQALHLqqnIK-VTPHPDGYEGE-LVDSIAKTITGIP-------LDKLSFEEFLQQ 211 Mycoplasma pneumoni...
O27496   150 GYDVETQYYVNDMGRQIAMIVWGLLNLDGDledYP-GDKMDHRVGKL-YFEVNQRLKENPG-------IRDEVDELIRKY 220 Methanothermobacter...
Q57689   152 GYDVETHYYVNDMGRQMALVVYGIELFGLDk-----eKKKDHAIAET-YVKINKYLEEHPE-------EEEKILELMRKY 218 Methanocaldococcus ...
O29368   141 GFDVKTHYYVNDMGRQTAITVLGIEKFGLKd------kKPDHAVAEA-YIEANKLLESNPE-------LEEQVEKLMLAY 206 Archaeoglobus fulgi...
O51540   155 GAKITKINLINDRGVHICKSMLAYKKFGNGitpEKaFKKGDHLIGDF-YVKYNKYSQENEN-------AEKEIQDLLLLW 226 Borrelia burgdorfer...
AAB68931 216 GWSVTRMNYLGDWGRQFGLLAVGFKRYGDEk--TL-QKQPIQHLFDV-YVKINMDLAKEEIngnskcgISGEARSFFKNL 291 baker's yeast
Q05506   180 GWEVIRMNYLGDWGKQFGLLAVGFERYGNEe--AL-VKDPIHHLFDV-YVRINKDIEEEGDsipleqsTNGKAREYFKRM 255 Saccharomyces cerev...
4OBY_A   219 QSGDeyfr-----emwRKLVdiTMTQNQITYDRLNVTLTRDdvmGESLYNPMlpGIVADLK-AKGLAVEsE-GATVVFLD 291 Escherichia coli K-12
P56128   222 LSGY------------ARDL--MLLEIKDNLDALGIHFDSYaseKEVFKHKD--AVFEQLEkANALYEK-D-SKIWLKSS 283 Helicobacter pylori...
P46906   226 EESErla------ffrEYGLkyELEKLRKDLENFRVPFDVWyseTSLYQNGKidKALEALR-EKGHVYE-EdGATWFRST 297 Bacillus subtilis s...
P75222   212 PFLDql---------lADCTakVLEVIKQDLATIHIHFDSWkfeSQVVKETDykKLLTQFK-DEAHYEK-D-GAIWLKTT 279 Mycoplasma pneumoni...
O27496   221 EAGEnee-------lfRKVVeyCLSGMEETMKRLHVHHDRFvweGQFVRDGTvdRVIESLR-KTGYTGE-N-DVLYLDLE 290 Methanothermobacter...
Q57689   219 EDALennedneitkkfEFAVnyALDGIKETLKNLNIKHDTFvweSSYVRNGMvkKVIEKLM-ETGKVIK-E-ETYMLDLS 295 Methanocaldococcus ...
O29368   207 EEGDektv-----ekfRRAVetALEGIKQTLKTINVEHDEFvweSEFVRNGYvgKVLGILE-ERGLVKK-N-GAWTIELE 278 Archaeoglobus fulgi...
O51540   227 EQKDvsti-----elwKKLNkwAIEGIKETYEITNTSFDKIyleSEIFKIGKn-VVLEGLEkGFCYKRE-D-GAICIDLP 298 Borrelia burgdorfer...
AAB68931 292 ENGDenai-----kiwNRFRslSIHHYIQTYSRLNINFDIFs--GESQVSKEsmNEALDIFrKNNLVKE-IdGALVIDLT 363 baker's yeast
Q05506   256 EDGDeeal-----kiwKRFRefSIEKYIDTYARLNIKYDVYs--GESQVSKEsmLKAIDLFkEKGLTHE-DkGAVLIDLT 327 Saccharomyces cerev...
4OBY_A   292 EFKNKeg--epMGVIIQKKDGGYLYTTTDIACAKYRYETlHADRVLYYIDSRQHQHLMQAWAIVRKAGyvPESVPLEHHM 369 Escherichia coli K-12
P56128   284 LYQDE------SDRVLIKEDKSYTYLAGDIVYHDEKFKQ-DYTKYINIWGADHHGYIARVKASLEFLG--YDSNKLEVLL 354 Helicobacter pylori...
P46906   298 TFGDD------KDRVLIKKDGTYTYLLPDIAYHKDKLDR-GFDKLINVWGADHHGYIPRMKAAIEALG--YEKGTLEVEI 368 Bacillus subtilis s...
P75222   280 LYGDD------KDRVLVRQDNRPSYFGTDVAYHLDKAAR-GFDLLYDIWGSDHEGHIKRMHCVYEGLKi-HQKCQLKITA 351 Mycoplasma pneumoni...
O27496   291 EFG-Le-----KELVLTRSDGTSLYSTRDIAYHLQKSE--EGDVIIDVLGSDHKLAAEQVGIAVELLG--GKRPEVIFYE 360 Methanothermobacter...
Q57689   296 DFG-Ie-----KKMVLARANGTSLYSTRDIAYHLDKLS--KCDIGIDVLGADHKLTAEMVKAALKLLG--SKVPEVIFYE 365 Methanocaldococcus ...
O29368   279 GFd--------KEVVLRRENGTTLYITRDLAYHMWKNE--NYERFINVLGADHKLYGAQLSKILELLG--LKPPEIIFFE 346 Archaeoglobus fulgi...
O51540   299 SDSDEkadtkvKQKVLIRSNGTSIYLTQDLGNIAVRTKEfNFEEMIYVVGSEQIQHFKSLFFVAEKLGl-SKNKKLIHLS 377 Borrelia burgdorfer...
AAB68931 364 QWSKRl-----gRVVVQKSDGTTLYLTRDVGAAIERKKNlHFDKMVYVISSQQDLYMSQFFMILKKMNf-EWAKDLQHIN 437 baker's yeast
Q05506   328 KFNKKl-----gKAIVQKSDGTTLYLTRDVGAAMDRYEKyHFDKMIYVIASQQDLHAAQFFEILKQMGf-EWAKDLQHVN 401 Saccharomyces cerev...
4OBY_A   370 FGMMLGKDgkpfktraggtvklADLLDEALERARRLVAEKnpdmp-adeleKLANAVGIGAVKYADLSKNRTTDYIFDWD 448 Escherichia coli K-12
P56128   355 AQMVRLLK--------------DNEPYKMSKRAGNFILIK-----------DVVDDVGKDALRFIFLSKRLDTHLEFDVN 409 Helicobacter pylori...
P46906   369 IQLVHLYK--------------NGEKMKMSKRTGKAVTMR-----------DLIEEVGLDAVRYFFAMRSADTHMDFDLD 423 Bacillus subtilis s...
P75222   352 LQLVMLYK--------------NKEIVRLSKRAGNVITIKq-----------MLQMLSEDAARWFMLSQTNNSIIKIDLD 406 Mycoplasma pneumoni...
O27496   361 FITLPEGSmstrrg---vfisvDELMDEAHSRALHEVKKRrdlpd--dvadDIAESIGNGAIRYYIARLSPEKHIVFRWD 435 Methanothermobacter...
Q57689   366 FISLPEGSmstrrg---rfistDELLEEAIKRAKEECNKRgv-------eeNIAYDIGLGAVRYNIARISPEKPMVFRWE 435 Methanocaldococcus ...
O29368   347 FVSLPEGSmstrrg---kfisaDELISKVRDEAWKILSERdmee---dekrKIADAVAVGAIRFDFIKIAPEKHMTFDWS 420 Archaeoglobus fulgi...
O51540   378 HGMVNLVDgkmksre-gnvidaDNLISNLIELIIPEMTQKienk---esakKNALNIALGAIHYYLLKSAIHKDIVFNKK 453 Borrelia burgdorfer...
AAB68931 438 FGMVQGMStrkgn-----vvflDTILDEARDKALQIMENNkmkisqvdnpqRVADLIGVSAIIIQDMKSKRINNYEFNWN 512 baker's yeast
Q05506   402 FGMVQGMStrkgt-----vvflDNILEETKEKMHEVMKKNenkyaqiehpeEVADLVGISAVMIQDMQGKRINNYEFKWE 476 Saccharomyces cerev...
4OBY_A   449 -NMLAFEGNTAPYMQYAYTRVLSVFR-KAEIDEEQLAAAPVIIR--EDREAQLAARLLQFEETLTVVAREGTPHVMCAYL 524 Escherichia coli K-12
P56128   410 tLKKQDSSNPIYYIHYANSRIHTMLE-KSPFSKEEVLQTPLTNL--NAEEKYLLFSALSLPKAIESSFEEYGLQKMCEYA 486 Helicobacter pylori...
P46906   424 lAVSTSNENPVYYAQYAHARICSMLR-QGEEQGLKPAADLDFSHiqSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYI 502 Bacillus subtilis s...
P75222   407 tANLQNSSNPVYYVQYAYARMCSVLK-VVDQAALAQVNDCSLLT--HEKEIALLDQLVYFKSLLEKVQVSHELHLLTNYL 483 Mycoplasma pneumoni...
O27496   436 -DALSFER-GCASIQYAHARACKLLE-KASFTGEEDIEDG-WKP--EGDERELVRLLARFPVVVEESALARRVHPVAQYA 509 Methanothermobacter...
Q57689   436 -EALDFEKVGCPFIQYAHARCCSILK-EAENKGVKDEAVFNYEL--TSEEKELIKMLDEFKDIIKESAESRRVHILANYL 511 Methanocaldococcus ...
O29368   421 -KALDFERQTASYIQYSHARACSILR-KAVEDGMPELEFKGELC--TAGERKLVMLLSKMPYVVKRIVSELRPNVFAEYL 496 Archaeoglobus fulgi...
O51540   454 -ESLSFTGNSGPYIQYVGARINSILEkYKALSIPVMEKIDFELLk-HEKEWEIIKIISELEENIINAAKDLNPSILTSYS 531 Borrelia burgdorfer...
AAB68931 513 -RMLSFEGDTGPYLQYTHSRLRSLERtSSDFTTDMLIHADFSNLn-EPQLVELVRLLAQYPDVLRRAFETQEPATIVTYL 590 baker's yeast
Q05506   477 -RMLSFEGDTGPYLQYAHSRLRSVERnASGITQEKWINADFSLLk-EPAAKLLIRLLGQYPDVLRNAIKTHEPTTVVTYL 554 Saccharomyces cerev...
4OBY_A   525 YDLAGLFSGFYEHCPILSAEne-eVRNSRLKLAQLTAKTLKLGLDTLGIETVERM 578 Escherichia coli K-12
P56128   487 KTLASEFHRFYNAGKILDTP----KAKELLKICLIVSLSLSNAFKLLGIEIKTKI 537 Helicobacter pylori 26695
P46906   503 YDLASALHSFYNAEKVIDPEne-eKSRARLALMKATQITLNNALQLIGVSAPEKM 556 Bacillus subtilis subsp. subtilis str. 168
P75222   484 YETATLFHSWYKACKINDPAqy-nLTQQRLLLLQSLHHVFGQLLQILNITAPQQM 537 Mycoplasma pneumoniae M129
O27496   510 QDLANTFNSFYRSTPVIGSd----FEGARLRLVDSVRKTLRNALNLLGIHAPETM 560 Methanothermobacter thermautotrophicus str. ...
Q57689   512 LELAKAFNRFYANCPILMTKvdddVKKSRLKLVKSTKTVLETGLELLGINCPGRM 566 Methanocaldococcus jannaschii DSM 2661
O29368   497 LSVAGTFNDFYRDHPVLKAEs--eVRMHRLAIVDATRVVLRNGLELLGIEPLERM 549 Archaeoglobus fulgidus DSM 4304
O51540   532 YSLAKHFSTYYQEVKVIDTNni-nLTAARIEFLKAILQTIKNCMYLLNIPYMLKM 585 Borrelia burgdorferi B31
AAB68931 591 FKVCHQVSSCYKKIWVSGKPa--dIAIPRLAVYSASRQVLHNAMSLLGLVPVDRM 643 baker's yeast
Q05506   555 FKLTHQVSSCYDVLWVAGQTe--eLATARLALYGAARQVLYNGMRLLGLTPVERM 607 Saccharomyces cerevisiae S288c
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