2MSX


Conserved Protein Domain Family
MANEC
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pfam07502: MANEC 
MANEC domain
This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.
Links
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Statistics
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PSSM-Id: 462186
Aligned: 47 rows
Threshold Bit Score: 81.5879
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2MSX_A         2 ADCLNSFTa-GVPGFVLDTQASVSNGATFLE-SPTVRRGWDCVRACCTT------QNCNLALVELQPDr-gEDAIAACFL 72  human
XP_006627737  28 DGCPEAFVklTGQGL---DQQSFDNGASYSGhLPDVSDEASCRQACCGH------KECTLALLESTA-----GAPAECHL 93 
Q0VC64        27 QNCLTE----SLEDVVIDIQLSLSKGIRGNE-PIHTLTPQDCINSCCSTknisgdKACNLMIFDTQK----KFKLPNCYL 97  cattle
XP_005010093  23 QGCSAE----KEENAIVDISFALPAGIRGAE-PVYASAPEACMRACCLGkglpgdKKCNFMIFDARG----TKTHPNCYL 93 
Q9CR33        26 QNCLTK----SLEDVVIDIQSSLSKGIRGNE-PIHLATQEDCIGACCSTkdiagdKACNLMIFDTRK----TDRQPNCYL 96  house mouse
EDO43585      28 DGCPKIq---VKKNQILRTKEALNNGAKYLK-RAVISTARECYNLCCRH------SSCNLAMISYTNStsgSDAVRMCYL 97 
EDW03570      43 ESCIGHFD--VHKNTIIRTGESQAIGGKYLQ-GLELDTLEECERLCCET------DACDVYIFERKA-------GGYCYL 106
EEB18768      38 ETCIENFD--IHIDKIIRTQDSRAMGAKYLN-EADVNGREDCMKLCCET------SLCDVFVMEQKV-------PGSCYL 101
XP_001952847  26 FGCANRFE--VHDDKIIRTEDSKKLGAKFID-SVEQHDRAGCLELCCRT------SRCDVFVFEEKS-------PGTCYL 89 
XP_014353462  25 EHCFTD----QMEDVIIDIKAALPLGVRSRE-PLYTAAAEVCTNLCCDGvki-neKKCNLVIFDFRK----HPQQDNCYL 94  coelacanth

2MSX_A        73 INCLYEQNFVCKFAPREGFIN 93  human
XP_006627737  94 VSCLSAGRDVCVLTAKDGFTA 114
Q0VC64        98 FFC--PSEEACPLKPAKGLMS 116 cattle
XP_005010093  94 FYC--PSTEACPMKPATGFVS 112
Q9CR33        97 FFC--PSEDACPLKPAKGLVT 115 house mouse
EDO43585      98 FDC--GSPSKCMYAPYSHYAT 116
EDW03570     107 FECGPPENFHCKFTRHANYTS 127
EEB18768     102 FHCGSPEDFKCKFTQHKNYTS 122
XP_001952847  90 FECGPSDDFKCKFTNHKNYSS 110
XP_014353462  95 FHC--PSAEACPMKTLKGLKS 113 coelacanth
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