Conserved Protein Domain Family
P450_pinF1-like

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cd20629: P450_pinF1-like 
cytochrome P450-pinF1 and similar cytochrome P450s
This subfamily is composed of bacterial CYPs similar to Agrobacterium tumefaciens plant-inducible cytochrome P450-pinF1, which is not essential for virulence but may be involved in the detoxification of plant protective agents at the site of wounding. The P450-pinF1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410722
Aligned: 18 rows
Threshold Bit Score: 400.523
Created: 25-Mar-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                      #   #      #   
117299     50 RPFLRREd----GIFLVLrADHIFLLGTDprtrqietelmlnrgvkagavfdfidhsmlfsnGETHGKRRSGLSKAFsfr 125 Agrobacterium tume...
CAN94969   29 HSVYFDEg---lGVPVVLrGADVVAVLRDsetfstrtydt-----------gimkgalvtlgGEAHTRMRRLFNAVLspr 94  Sorangium cellulos...
ABK67620   46 MPHEESK-----PVFIVYrHEDAQQMLRDnetfssaaviaaf-------gpvlgervmlgmdEPVHGRLRSLVSKAFsqk 113 Mycobacterium aviu...
ACA95992   53 MGGAADLtmsdvAHYCVFgYDEVSHVLGDpatfsnksyernl--------gisfgrsistmdAPEHPRYRRIFQKAFlph 124 Burkholderia cenoc...
ABK66916   48 LPEELRPe----DEWVLFdYESVSQAFRDdrifsshkydeti--------glvmghtilamgGREHHDHRNLVAKAFrat 115 Mycobacterium aviu...
ABK70900   44 TPKELMPe----HQYAAMsFDAVNTVFRDgktfnskiydsti--------glfigpsilameGKTHRDHRNLVSAAFksk 111 Mycobacterium smeg...
ABQ66735   55 LPAALYPd---rKMFTVVgSREVNEVLTDtdrfsnagykfnl-------gvtfgqgsistmdNPEHGRWRRIFQKIFlpq 124 Sphingomonas witti...
EAZ58767   53 VPTNAGIqqgtrPTFALFkYQDVMAVLRDgntytsgfiaegl-------gaffdglvilamdGEAHRKVRALLQPAFmpe 125 Pseudomonas aerugi...
ABE36529   55 IPTNAGAsa-akCEVTLFrYQDVLAVMRDattftngfiaegl-------ggffdgliilamdGDAHRRARGLLQPVFmpe 126 Burkholderia xenov...
ABZ71041   55 ASFAGQTg---rPIYTIFrHADVMKVLRDtktftsgilmetgl------gqfldglmitgldGDEHRQLRGILQPSFtpa 125 Caulobacter sp. K31
Feature 1                                               #                                     
117299    126 m--vealRPEIAKITECLWDDLQkvddfnftemYASQLPALTIASVLGLPsed---tpfFTRLVYKVSRCLspswrd--e 198 Agrobacterium tume...
CAN94969   95 vi-sryeEATVTPVARRVVERLVrkeraelfddFAISMPMGVTSALFGLPeer---iaeNDALIRKMIRSVvmpqdp--- 167 Sorangium cellulos...
ABK67620  114 al-arweDELVGRVGNSLIDRFAgngkadlvkeFTFDYPSRIIAGLLGLPeqd---ypqFQRWSISLLSWIlnp------ 183 Mycobacterium aviu...
ACA95992  125 tv-aawgDTLVDPVVSELMSKFVdrghadlvneFTLHYPFNIIYRQLALPped---vkiFHKLAIAQTLVSidv------ 194 Burkholderia cenoc...
ABK66916  116 al-erwePSVIGPVCEQLVDEIKndghadlvkaVTFEFPTRIISTLLGLPaed---ldlFRRLSLDLISIPtdi------ 185 Mycobacterium aviu...
ABK70900  112 sl-arwePEIARPICEALVDEFVdtgsadlvrdYTFEFPTRVISKLLGLPeed---lpwFRRRAVELISYSvky------ 181 Mycobacterium smeg...
ABQ66735  125 yv-kkwgETIVDPVVHGLMGKFLplgradlieqFTLRYPFEVIYHQLDLPeed---vrtFQRLALGQTDYVnhe------ 194 Sphingomonas witti...
EAZ58767  126 sv-nkwrGQIDEAIREEYLKPLVpqkka-dlmeFGLELPIRIMYALMGFPtddpskykqYAAWALAMVGGNqidpakmae 203 Pseudomonas aerugi...
ABE36529  127 tv-nrwrPELDRVIREDFLAPLVpnrha-dlmdFGLYFPIREMYALMGFPtddtakfnqYATWALAMVAGNqidpgkiri 204 Burkholderia xenov...
ABZ71041  126 vmeewreTYIRPLIQRSFVEPLValgkteligsVGVMFPIHVVYAVLGFQdndpaaletFATKALKVLGGMaddpd---- 201 Caulobacter sp. K31
Feature 1                                                              ##  ##  ##  #          
117299    199 efeeiEASAIELQDYVRSVIadsg--rrmrDDFLSRYLKAVREAgtlsPIEEIMQLMLIILAGSDTTRTAMVMVTALALQ 276 Agrobacterium tume...
CAN94969  168 vvvaeGRSAHAAMEAQLREIaerev-ahpsDTLLGEIARAIVAEglggVEACEGVVLTLILGSYETTSWMLANLLVALLA 246 Sorangium cellulos...
ABK67620  184 --qrgLAASAALCDYFAPILaarr--tepkDDLISGLAQAEIDGekleDEEIYSFLRLLLPAGVETTYRALGSLLLALLS 259 Mycobacterium aviu...
ACA95992  195 --ahgMEASTKLGAYFAKLIddrr--rtpgDDLVSMLATAEVEGerlpDEVVISFLRQLVNAGGDTTYRATSVLLLALLR 270 Burkholderia cenoc...
ABK66916  186 --eagLNAATELYDYFLKQVeqrr--rkptDDIIGDLVAAEIDGekltDEAIIAFLRLLLPAGLETTYRSSGNLLYLLLT 261 Mycobacterium aviu...
ABK70900  182 --kraFEASAALKDYFLDQIerrr--srptEDIIGDLVTAEIDGekltDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLT 257 Mycobacterium smeg...
ABQ66735  195 ---kaIEAGRKLGDYFTALVeerr--rdpgDDLVSLLASTEADGeylpHEVLISFLRQLMNAAGDTTYRGTSILLTALLE 269 Sphingomonas witti...
EAZ58767  204 arkqaGIAVKGLYDAIQGVVvqrraegshgDDVVGRLLRAEYEGrtldDHEVITFTRSLLPAAGETTTRMFGSVMAMLLT 283 Pseudomonas aerugi...
ABE36529  205 fgpiaAAAVKHLYDAVMEVVlqrraagadgNDLISRLMRAEYEGhkldDHEVTTFVRSLLPAAGETTTRTFSSVITLLLE 284 Burkholderia xenov...
ABZ71041  202 akraaFQAFQELYDPTLAAVqarrasgaegADLISRLIRAEFEGrtlnDHQITNFVRMMLPAASETTSRTFATMLTHLFD 281 Caulobacter sp. K31
Feature 1                           #        # #                      #                       
117299    277 NPaLWSSLRGNqsyVAAAVEEGLRFEPpvGSFPRLALKDidldgyvLPKGSLLALSVMSGLRDekhyehPQLFDVGRQqm 356 Agrobacterium tume...
CAN94969  247 HPdAMNQLRQQpslLPQAIEESTRWCSsaAGIVRFVEREatiggetLAAGTILYLSLIARHYDeeiyprPETFDIHRRpv 326 Sorangium cellulos...
ABK67620  260 DPeQLDAIRGDrslLPQAIEEGVRWEPplLTITRVATRDtelggvpIPAGSTVMPMLGAANRQedrypdPDRFDIFRApk 339 Mycobacterium aviu...
ACA95992  271 NPeQLEAVRNDrtlVAQAIEEALRWDGpvLMQSRMATRDvtlggveIPAGAFLDVVAGSANRDpsrfpdPDKFDIYRKpa 350 Burkholderia cenoc...
ABK66916  262 HPeQLAMVYRDrslIPMAIEEGLRFETplTMVTRTTTEEveiggktIPANAQIDMCMGSANRDetrwtdPNAFDIRRPrq 341 Mycobacterium aviu...
ABK70900  258 HPdQFAAVQNDhdlIGAAIEEGLRYETplTTVQRSATKDtelegvqIPAGAVIDVCIGSANRDenrwerPEEFDIFRKri 337 Mycobacterium smeg...
ABQ66735  270 HPdQMEAIRADrglIPQAIEEALRWDGpvAVQMRMAAVDtelagvaIPAGSLLDVVAGAANRDpeiysdPDRFDIFRDrk 349 Sphingomonas witti...
EAZ58767  284 TPgLLERVKADrslIPKLMDETTRYEPvaTFKVRETAKDvefhgvkIPKGSFVQCMVVSANRDpdafenPDVFDIDRKlk 363 Pseudomonas aerugi...
ABE36529  285 RPaLVERVRNDrslIPRLIDEAVRYEPvaTFKVRQAARDieiggvkVRSGGLVQCMVMSANRDedvfenADTFDIDRKpk 364 Burkholderia xenov...
ABZ71041  282 HPeVLERLRADrslMRKVLDESVRHDAvaTFKVRECQADvtlqdvtIPKGSIISACVASANRDelvfdkPEVFDIDRKqm 361 Caulobacter sp. K31
Feature 1         ###   #####  ##                                  
117299    357 rwhLGFGAGvHRCLGETLARIELQEGLRTLLRRAPnlAVVGDWPrMMGHGGIR 409 Agrobacterium tumefaciens
CAN94969  327 -gmLNFGGGlHYCVGAPLARMEARVGVSLLLERFPalRADPTVQ-PTFSTAPR 377 Sorangium cellulosum 'So ce 56'
ABK67620  340 -shLGWGHGvHVCLGMHLARLEMRTAVNLLLDRLPnlRLDPDADdPHIRGQVF 391 Mycobacterium avium 104
ACA95992  351 hrhFAFAYGpHVCIGQHLARVEMTRALNAILDRLPnlRLDPGAPaPEINGIMM 403 Burkholderia cenocepacia MC0-3
ABK66916  342 -ahIAFAGGiHMCLGMHLARLETRVMLNSLFDRVRdlAFVPDDGtGEESKIVG 393 Mycobacterium avium 104
ABK70900  338 -phITFAAGeHTCMGLHLARMETRVAMETLLNRVTdlRLIADDD-PHIFGQPF 388 Mycobacterium smegmatis str. MC2 155
ABQ66735  350 -phFAFSRGpHICVGQHLARVEMTRALHAVLDHLPglRFDPDEPrPRIQGSMM 401 Sphingomonas wittichii RW1
EAZ58767  364 -psFGFGFGpHMCIGQFIAKVEISCSINAILDLFPniRLDPSKPaPVIEGAQL 415 Pseudomonas aeruginosa 2192
ABE36529  365 -psFGFGFGaHMCIGQFVAKIELQCAVNAILDLFPnvRLDPARPaPKIAGAQL 416 Burkholderia xenovorans LB400
ABZ71041  362 -paFGFGFGaHMCVGMWLAKVEIEEAVGLLLDMLPnlRLDPDHPrPEVRGVSL 413 Caulobacter sp. K31

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