1NKP,5I4Z


Conserved Protein Domain Family
bHLHzip_c-Myc
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cd11458: bHLHzip_c-Myc 
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basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins
c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.
Links
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Statistics
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PSSM-Id: 381464
Aligned: 10 rows
Threshold Bit Score: 118.06
Created: 16-Nov-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:1NKP; Homo sapiens bHLHzip c-Myc transcription factor basic region binds the DNA, contacts at 4.0 A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #   ##  ## ### ##   #                   ##                                      
1NKP_A         2 HMNVKRRTHNVLERQRRNELKRSFFALRDQIPELeNNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHK 81  human
P06171       332 EENDKRKTHNVLERQRRNELKLSFFALRDQVPEVaSNEKAPKVVILKKATEYAISLQEDERRLIRETEQLKYRKEQLKQR 411 African clawed ...
5I4Z_A        30 EENVKRRTHNVLERQRRNELKRSFFALRDQIPELeNNEKAPKVVILKKATAYILSVQAETQKLISEIDLLRKQNEQLKHK 109 human
P01106       351 EENVKRRTHNVLERQRRNELKRSFFALRDQIPELeNNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHK 430 human
P01109       328 EENDKRRTHNVLERQRRNELKLSFFALRDQIPEVaNNEKAPKVVILKKATEYVLSIQSDEHRLIAEKEQLRRRREQLKHK 407 chicken
Q7ZVS9       310 EDNDKRRTHNVLERQRRNELKLSFFALRDVIPDVaNNEKAAKVVILKKATECIASMQEDEQRLISLKEQLRRKCEHLKQR 389 zebrafish
P15171       333 EENDKRRTHNVLERQRRNELKLSFFALRDQVPRWrNNEKAPKVVILKKATEYAISMQEDERRLIRETEQLKYRKEQLKQR 412 African clawed ...
XP_007901659 523 EENDKRRTHNVLERQRRNELKLSFFALRDQIPEVaKNDKAAKVVILKKATEHVLSIQSMEQRLITEKEQLRKKREQLKHR 602 elephant shark
XP_005992710 305 EENDKRRTHNVLERQRRNELKLSFFALRDQIPEVaNNEKAAKVVILKKATEYILSIRAEEQRLTVEKEQLRRKREQLKHK 384 coelacanth
P52160       321 EDNDKRRTHNVLERQRRNELKLSFFALRDEIPEVaNNEKAAKVVILKKATECIHSMQLDEQRLLSIKEQLRRKSEQLKHR 400 zebrafish

Feature 1            
1NKP_A        82 LEQL 85  human
P06171       412 LQQL 415 African clawed frog
5I4Z_A       110 LEQL 113 human
P01106       431 LEQL 434 human
P01109       408 LEQL 411 chicken
Q7ZVS9       390 LEQL 393 zebrafish
P15171       413 LQQL 416 African clawed frog
XP_007901659 603 LEQL 606 elephant shark
XP_005992710 385 LAQL 388 coelacanth
P52160       401 LQQL 404 zebrafish

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