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C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",