1EQF,1EQF


Conserved Protein Domain Family
Bromo_TFIID
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cd05511: Bromo_TFIID 
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Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Links
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Statistics
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PSSM-Id: 99943
Aligned: 19 rows
Threshold Bit Score: 147.796
Created: 13-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #    #  #                                      #   #    
1EQF_A         27 LSSILESIINDMRDLpnTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRlYPSREEFREHLELIVKNSATYNGP-- 104  human
ABC86258     1475 LSSILEIIHNELRSMpdVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRrYTSREMFLEDLKQIVDNSLIYNGP-- 1552 fruit fly
NP_001038250 1451 LSSVLESIINDMRDLpnTYPFHTPVNGKVVKDYYKIITRPMDLQTLRENVRKRmYPSREEFRESVELIFKNSATYNGA-- 1528 zebrafish
EAT42378     1450 LSSLLEQILNELRDMpdVAPFMFPVNAKQVVDYHKIIQRPMDLQTIREHIRQKkYQTRDEFIADINQIVENSSLYNGA-- 1527 yellow fever ...
CAE68007     1399 LSTMLTDVLNELKSLegSDAFLFPVNPKQVTDYYNIIKNPISFQDIKNKIASYsYQLRKEFIEDIRLMHGNSRMYNGE-- 1476 Caenorhabditi...
CAE68007     1521 FCFVLDQIIQKVRNIpkSAPFHTKVDGKRFPSYYVRIQNPIDLGTIEQKNKRHeYQSIDDFLKDMRLILDNSLAFNGE-- 1598 Caenorhabditi...
NP_493426    1583 FSYLLGEIVQKMKNIpkSALFHTRVDPKKIPAYYLKISDPMDLSIMEQKSKSQeYKSIDEFLKDAEKIYTNSVVFNGA-- 1660 nematode
XP_786789    1463 MSGILEEILNAIRELpyTQPFHTAVEKRKFPDYYKIVSKPIALQTIRDNVRKHrYASRDSFEADINQIVDNSILYNGE-- 1540 purple urchin
EDP30771     1429 MSIVLSEIFNDVRSIsgCEEIMFPVNPKKVPDYYNIIKEPMDLQQIKTKISENkYELRRQFLYDIKLIMDNSILYNGG-- 1506 agent of lymp...
EDP30771     1551 FSFILNEIVQECKNIpkSVAFHFKVDPKKLPQYYEKIHKPMDLGTMQQNIKEHrYTTVEAFRNDIKQIRMNSELYNGPpe 1630 agent of lymp...

Feature 1            #                              
1EQF_A        105 KHSLTQISQSMLDLCDEKLKEKedkLARLEKAIN 138  human
ABC86258     1553 QSAYTLAAQRMFSSCFELLAERedkLMRLEKAIN 1586 fruit fly
NP_001038250 1529 KHPLTVVAQAMLSLCVEKIKEKeerLVRLEKAIN 1562 zebrafish
EAT42378     1528 KSSLTIAAQRMLQKCKDRMQEKeerLTRLEKSIN 1561 yellow fever mosquito
CAE68007     1477 NHVLTMNAADILKRAGFLLALRdseFMKLEKQIN 1510 Caenorhabditis briggsae
CAE68007     1599 ASIYTAKAKEIWQLTERLVQENmetLVELEKNIN 1632 Caenorhabditis briggsae
NP_493426    1661 ESVYSLKAKEMFEMAEMLVKDQmdtLGELERNIN 1694 nematode
XP_786789    1541 MSPLTMVAKNMLLMAQKKMQEKterMSRLEMAIN 1574 purple urchin
EDP30771     1507 GHSITITAKNVFEMASRYVAEReqkLIALEKAIN 1540 agent of lymphatic filariasis
EDP30771     1631 TSQYTSKAVEICTLAEKMLEERkeqLAELEMNIQ 1664 agent of lymphatic filariasis

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