4WCX,4RTB


Conserved Protein Domain Family
ThiH

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COG1060: ThiH 
2-iminoacetate synthase ThiH/Menaquinone biosynthesis enzymes MqnC and MqnE [Coenzyme transport and metabolism]
2-iminoacetate synthase ThiH/Menaquinone biosynthesis enzymes MqnC and MqnE is part of the Pathway/BioSystem: Thiamine biosynthesis
Statistics
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PSSM-Id: 440680
Aligned: 841 rows
Threshold Bit Score: 178.014
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4WCX_A        45 EIIEKAKNLkGITPEEAAVLL----NV-EDEdlLNEMFKVARYIKEEIYG-----NRI--VIFAPLYVSNYCVNNCRYCG 112
WP_012086641  27 AAL-RAAAGgDLDAATAEVLL----HArGED--LGALCALAAPVRDAAMAaagrpGVVtySRKVFVPVTRLCRDRCHYCT 99 
WP_012825326   7 GVIARAAEr-PLSDGELSALAeldaAAlERR--TGDLMRAAAERRDRAWG-----RALsfSPKVFLPLTNLCRDACDYCS 78 
WP_012866406   8 AALTRAEQSgTTTQDDATLLL----AArGDE--LERLLVLASRIRDEGLEragraGVItySKKVFVPLTKLCRDRCHYCV 81 
WP_014927577   9 AALAAARDRaPIGLDEAEALL----ACsGDD--LAELQSIAGAIRDEGLEaagrpRQItySRKVFIPLTRLCRDRCHYCT 82 
WP_081790051  62 raLRRAADGsALDVTEAAVLL----HArGEH--LDELLLAAGKVRDAHLAaegrsGIVtySRKVFIPLTRLCRDRCHYCT 135
WP_081790051  62 raLRRAADGsALDVTEAAVLL----HArGEH--LDELLLAAGKVRDAHLAaegrsGIVtySRKVFIPLTRLCRDRCHYCT 135
WP_081656849   5 TVLTRLDRGePLTRDSAALLL----EArGCE--LDALLEAAGRLRDEGLArrgrpGIVtySRKVFLPLTKLCRDRCHYCV 78 
WP_114704247  26 AALDAARAG-SPTQADAEVLF----AArGAD--LDELLEVASRMRDEGLErrgtpGVItySKKVFIPVTKLCRDRCHYCI 98 
WP_120788817  26 RLESAREPWvSLSHADATILL----AArDED--LDRLLLVAGRIRDDGLAaagrpGVItySRKVFIPLTHLCQDRCHYCI 99 
4WCX_A       113 YRHSNEQQ-----RKKLTMEEVRREVEILEEMGHKRLAVEAGEDPvNCP----------------IDYIVDVIKTIYdtk 171
WP_012086641 100 FATVPGRLp----VLYLSEDDVLAIAREGAAMGCKEALFTLGDAP-EDRwpaarawltargfastLEYVQHLARRVLde- 173
WP_012825326  79 FRRSPKQAg----AWTMTPREVDTWLRRGRAQGCVEALFCLGDTP-ESAfpsyraqlagwghestVAYLVAAGERALem- 152
WP_012866406  82 FVETPGSLrasgeQSFMEPEDILAVARAGAALGCKEALFTLGDRP-EDRwpsarawldehgysstLEYVRAMAVLVLee- 159
WP_014927577  83 FVTVPGKLarageGLYLELDQVVDLARRGAELGCKEALFTLGDRP-EDRwpqagewlaergysstLDYVRAAAVAVLse- 160
WP_081790051 136 FATVPHRLp----AAYLERDEVLEIARQGAAAGCKEALFTLGDRP-EERwpaarewleargysstLDYVRACAIAVLee- 209
WP_081790051 136 FATVPHRLp----AAYLERDEVLEIARQGAAAGCKEALFTLGDRP-EERwpaarewleargysstLDYVRACAIAVLee- 209
WP_081656849  79 FVETPGGLaahgtQTFMTAEEILDVAHAGAKLGCKEALFTLGDRP-EDRwptartwlaehgytstLDYLRAMAVLVLre- 156
WP_114704247  99 FVETPGGLarnhePTYLSREEILDIAREGAALGCKEALFTLGDRP-EDRwkqarawldehgyastIDYLRDMAQAVLee- 176
WP_120788817 100 FVQTPGKLtkagiSPYMEPEEVLEVARQGAALGCKEALLTLGDRP-ENRwpiarqwldehgyestLDYVKAMAELILae- 177
4WCX_A       172 lkngsirR-VNVNIAATTVENYKKLKKV--GIGTYVLFQETYH-RPtyEYM-HPQGP-KHDYDYhLTAMDRAMEAGIDdV 245
WP_012086641 174 -----tgLlPHLNPGVMTHADLLASRPLapSMGMMLETTSTRLwTE--PGQvHYGSPdKDPALR-LRVLRDAGRAGVP-F 244
WP_012825326 153 ------gLlPHTNAGVLGCTEIALLKRVnaSQGLMLESVSPRL-CA--KGMpHHRAPdKRPEKR-LAMLESAGALRVP-F 221
WP_012866406 160 -----tgLlPHLNPGVMSWAELQRLRPVapSMGMMLETTATRLwSE--KGGvHYGSPdKDPALR-LRVLEDAGRSKVP-F 230
WP_014927577 161 -----tgLlPHLNPGVMSLEELLRLRPVapSMGMMLETTSRRLfTE--KGQaHYGSPdKDPLVR-MQVLRDAGAARVP-F 231
WP_081790051 210 -----tgLlPHLNPGVLSWEELQRLKPVapSMGMMLETTATRLwSE--PGGpHYGSPdKEPAVR-LRVLTDAGRVGVP-F 280
WP_081790051 210 -----tgLlPHLNPGVLSWEELQRLKPVapSMGMMLETTATRLwSE--PGGpHYGSPdKEPAVR-LRVLTDAGRVGVP-F 280
WP_081656849 157 -----tgLvAHLNPGVMSWAELQRLRPVapSMGMMLETTATRLwSE--KGGvHYGSPdKDPTLR-LRVLEDAGRSRIP-F 227
WP_114704247 177 -----tgLlPHMNPGVMSWAELQTLRPVapSMGMMLETTATRLwSE--KGGvHYGSPdKDPALR-LRVIDDAGRSRVP-F 247
WP_120788817 178 -----tgLlPHLNPGVMSWAELQRLKPVgpSMGMMLETTSSRIwET--PGEaHFGSPdKDPAVR-LRVIDDAGRSRIP-F 248
4WCX_A       246 GLGVLYGLYDYKYETVAMLYHANHLEEKFGVGPHTISVpRLRPAlNISIDkfPYIVSDKDFKKLVAVIRMAVPYTGMILS 325
WP_012086641 245 TTGILVGIGETPAERVDSILAIRDVVAEFDGVQEVIVQ-NFRAKdDTAMRg-EDDLDHSEYLATIAVARLLLGPGVSLQA 322
WP_012825326 222 TTGILVGIGETERERIDSLVAIRDLHRRFGHIQEVIVQ-PFRARpAVPMAa-APEAGDRELLRAIALARLILDDEVAVQT 299
WP_012866406 231 TTGVLLGIGEDDAERAEALFAIRASHERHGHVQETIVQ-NFRAKpRTAMQn-DSDLELQEYIAAVAVARVVMGPDATVQA 308
WP_014927577 232 TTGILVGIGESLTERAESLLAIADVHARGGHIQEVIVQ-NFRAKpDTAMRs-TPDAEMTEFLAAVAVARIVLGPHMRVQA 309
WP_081790051 281 TTGILIGIGETIDERADSLMRIRRVAKQYGNIQEVIIQ-NFRAKpDTAMRg-MPDADLHELAATIAVARLLVPTGVSVQA 358
WP_081790051 281 TTGILIGIGETIDERADSLMRIRRVAKQYGNIQEVIIQ-NFRAKpDTAMRg-MPDADLHELAATIAVARLLVPTGVSVQA 358
WP_081656849 228 TTGVLLGIGETVTERADALFAIRDSHARWGHLQECIVQ-NFRAKpRTAMHk-KADLELQEYIASVAVARLVLGAQTSIQA 305
WP_114704247 248 TTGVLLGIGETDAERAEALFEIRRSHETFGHVQETIVQ-NFRAKpRTAMQn-EADLALQEYIAAVAVARVVMGPDATIQA 325
WP_120788817 249 TTGVLLGIGETAADRIDAVLALRASHEKHGHIQEVIVQ-NFRAKnATAMMg-AVDLETQEYAAAVAVTRVLLGPGMRVQA 326
4WCX_A       326 TREK--PK-----FREEVISIGISQISAGSCTgvggyhEEISKKGgskpqfevEdKRSPNEILRTLCEQGYLPSYCTACY 398
WP_012086641 323 PPNLsdPG-----QREQLLAAGVDDWGGVSPLt----pDHVNPER--------P-WPQLDDLARTTRAAGFRLAERLTAH 384
WP_012825326 300 PPNLgaSHtataaEVSALRGAGINDFGGISPVt----pDYISPGH--------P-WPQLDVLASACASAGATLVPRLPVY 366
WP_012866406 309 PPNLtdPH-----ELGLLVRAGIDDWGGVSPLt----aDHVNPER--------P-WPHIGDLAALTATAGFELRERLTAH 370
WP_014927577 310 PPNLvsPA-----ECAALIASGVDDWGGVSPLt----pDHVNPER--------P-WPHLDALAARTAESDFVLAERITAQ 371
WP_081790051 359 PPNLvgD------EQLLMLRAGIDDWGGVSPVt----pDHVNPER--------P-WPQIDDLAELTGRAGFALRERLTAY 419
WP_081790051 359 PPNLvgD------EQLLMLRAGIDDWGGVSPVt----pDHVNPER--------P-WPQIDDLAELTGRAGFALRERLTAY 419
WP_081656849 306 PPNLtdEQ-----ELDLLIRAGIDDWGGVSPLt----aDHVNPER--------P-WPNIDDLARVTASCGYRLHERLTAH 367
WP_114704247 326 PPNLtdRQ-----ELDLLVRAGIDDWGGVSPLt----pDHVNPER--------P-WPHLDDLATLTRSTGYELRERLTAH 387
WP_120788817 327 PPNLtdAG-----ELALLVRAGIDDWGGVSPLt----pDHVNPER--------P-WPQIEELARLTAEGGYTLRERLTAH 388
4WCX_A       399 -R 399
WP_012086641 385 pR 386
WP_012825326 367 pR 368
WP_012866406 371 pP 372
WP_014927577 372 pP 373
WP_081790051 420 pR 421
WP_081790051 420 pR 421
WP_081656849 368 pH 369
WP_114704247 388 pQ 389
WP_120788817 389 pH 390
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