1PJQ,2YBQ


Conserved Protein Domain Family
CysG

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COG0007: CysG 
Uroporphyrinogen-III methylase (siroheme synthase) [Coenzyme transport and metabolism]
Uroporphyrinogen-III methylase (siroheme synthase) is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Statistics
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PSSM-Id: 439778
Aligned: 893 rows
Threshold Bit Score: 112.475
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1PJQ_A       215 RGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVrrDADRVFVGKR---AGY---H-C---VPQEEINQ 284
WP_012500758   3 KGKVSIVGAGPGDPELLTLKAHRRLKEAEVVLHDSLISQGIMDFIpeSATKIYVGKR---LGDkqdQ-S---VRQNEINR 75 
WP_013459921  20 KGNVYLVGCGLGDVEQLTIKAYRTIKEAQIVLYDNLIPQEIIDLIppETRKIYVGKP---KDN---H-S---ISQERINH 89 
WP_012499501   7 KYPVAIVGTGPGDPDLLTVKAARLIQEAELIVYDCPPAGLVLEHFnlSAKVVYIDRR---ANAa-eQtS---SPGETLLN 79 
WP_012505853   7 GGRVVIAGAGPGDPELLTVKAARRLQQADAVLYDSLVTREILDLAakGADMVPVGKR---CGDgqdQ-T---QRQNAINE 79 
WP_128152446   8 LHKVNIVGIGPGHPDLLTIQATQILEQTDVILYDCLANQCILEDQrfQAKIEFVEKD---------------MTFQKMID 72 
WP_057953331   8 KKPIIIAGTGPGDPELLAVKAQKAIASADVIVYDATQIEHIIDFCqsKAKRVKINKD---KTR---N-Sd--TLRKEIIQ 78 
WP_118505836   1 mhAVAIVGAGPGDPDLLTVKAHRLIKDAQVILHDNLVSDRIMAISs-EAEKIYVGRK---FGD---T-SdqiSRQQKINE 72 
NP_662642     41 ENRVLIVGAGPGDPELLTVRGAAAIREADVILYDCGTVEPVLALAseRAAIVRVDRSpyeTGE---G-R---REQTPMIV 113
WP_012476207   8 QGFVSFVSGGPGPVDLLTLRGKSRIERAEVILYDALLDPSFLEIFpeSAQILYVGKR---AKE---H-Y---RTQTEINA 77 
1PJQ_A       285 ILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTGG 364
WP_012500758  76 LLVSHALEGKRCVRLKSGDPFIFGRGVEEVRALLKHNIDVEVIPGISAGIAAANLCHIPITERYKSSSVLFCTGHTAEYT 155
WP_013459921  90 LIADYAGQGFSVARLKSGDPYIFGRGSEEAIFLQERGFKVDVIAGISSCVSAPACAGIPPTARGYAASFSVVSAHLKEGE 169
WP_012499501  80 LIQENYMNGKKVVRLKVGDPMLFGGELNDYAALSKMNIPFEVVAGISAGTAAACSYALSISAKGESDAVTHLIVNEVGEN 159
WP_012505853  80 LMLDYARRGALCVRLKAGDPFVFGRGVEEVRFLTERQVTVEVIPGISAGIAAANLFHVPVTERYRTSSVILSTGHTSTCS 159
WP_128152446  73 IMENYYLEGKKVARLRSGDSMMFNSGGIESKILKERKIPFDVIPGITAAGAASSVFSIPTTELNESDALVHFISHDTPEN 152
WP_057953331  79 ILADYHKTGKRVVRLKTGDAFMFGSGAAETELLFEMNLPFSVIPGITAGMAAAVYGNVRISEKKEADTVTFYMANQKNHQ 158
WP_118505836  73 LLESYYRQGKKVVRLKSGDPYVYGRAAEEVRYLTIKKIPFEVIPGISAALAAANIHNIPITERNKSNAMLICTAHTADYS 152
NP_662642    114 VIREYRDRGLRVVRLKTGDPSLFGGEVDEGDVLTRLGIPWAAIPGICAGAAAASAYALPISRKFESDAVLNLIAAAITDD 193
WP_012476207  78 LLVEFAHQGKKVVRLKGGDASIFGRLSEEIQSLEAAGIPYEVIPGVSSVTAGAADLGLSLTVRGLSRQIIILDGHTILED 157
1PJQ_A       365 --EL-DWENLAA-EKQTLVFYMGLNQAATIQEKLIAFGMQADMPVALVENGTSVKQRVVHGVLTQLGelAQ--QVESPAL 438
WP_012500758 156 leHLeAVALLMK-AGTPLVLYMGLKNLEHVAAKLISVGVPCETPVCAVSRVSYPDQEMICGTLETIAqtLAqtDLKTPAI 234
WP_013459921 170 f-NT-EWLPLLQlSNHTTVVLMGLSLAGKIQKAALKSGVPKNLPVAIVSNASRANQQSVVTTLSRLTktAKt--LEGPAV 245
WP_012499501 160 lplLrDAARWLQ-HGTTLVLYMANPHLEKIFQCFAEEGIPEDMPVVAVGKAGWPDEFYISSNMKHLKygLPvsEGQSPIV 238
WP_012505853 160 meEFdSVVALLK-QGTPLVLYMGMKHLECICQRLLDAGFSPDFPLCAASRVSMPDQQLICATLGTICllLVktPLPTPVV 238
WP_128152446 153 faQIrDLTVLFK-YGTTIALYMANQNLTRILNIMKEENVDQNLPVVVVSRVSMPEETAIYTHLSELLgtLEtnQLRSPMV 231
WP_057953331 159 heNLeQIAQLLQ-TQATVALYMAENILPQIRDCLLKQKLPKHFPVVAVANASLPNQQVLSATLADIQsiLNkiPKNSSVV 237
WP_118505836 153 feQLnGIAHMLK-AGNTISIYMGLKSLHRIIPKLLEVCKDDTIPVNAASNVSRSNQSLITGTLGSIEeqIKnsTIQMPVV 231
NP_662642    194 falIrDAAHLLG-HGATVVLYMATANLPGILRTFREAGVPDAMPVVAVSKAGWPDEAFARTTLGELTaaGCsiALPEPVV 272
WP_012476207 158 --ER-SWMGMEN-FPGTIAILMGSQKTKELSERLIQKGVLPTTPIVLLENAGNPNATYTVSTLANTMleGMgkQTKGPGI 233
1PJQ_A       439 IIVGR-VVA-L-RD-----Kl---N--Wf----S--N 456
WP_012500758 235 FLMGK-HAQ-P-TE-----Vl--lS--------Q--T 251
WP_013459921 246 IVFGD-VVS-L-HG-----Kl---Peyql-qqvEfi- 269
WP_012499501 239 YFLGK-FVS-L-GNlp-------kAr------lEpiS 259
WP_012505853 239 FFVGEhAVp-I--S-----Q-------------Q--T 252
WP_128152446 232 FFIGK-HVK-IlND-----Kl---Ni------iQ--N 250
WP_057953331 238 FFIGK-KVH----Sifaa-----------pnqsE--- 255
WP_118505836 232 LIIGAnPIc---------------------------- 240
NP_662642    273 YHIGR-YVR-V-RNvp------agSqeFfvkapE--N 298
WP_012476207 234 LYVGE-ALRpLl-EntktiQnvihSass---flE--S 263
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