1X7O,1X7P,1X7P


Conserved Protein Domain Family
SpoU-like_AviRb
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cd18107: SpoU-like_AviRb 
Click on image for an interactive view with Cn3D
SAM-dependent rRNA methylase related to AviRb
AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349980
Aligned: 9 rows
Threshold Bit Score: 230.738
Created: 22-Jan-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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SAM bindingdimer interface
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
  • Structure:1X7P; Streptomyces viridochromogenes AviRb with bound SAM, contacts 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #     #                                                             
1X7O_A    127 LGVLFDRPTSPGNIGSIIRSADALGaHGLIVAGHaadvydPKSVRSSTGSLFSLPAVRVpspGEVXDWVEARRaagtpiV 206 Streptomyces virid...
1X7P_B    127 LGVLFDRPTSPGNIGSIIRSADALGaHGLIVAGHaadvydPKSVRSSTGSLFSLPAVRVpspGEVMDWVEARRaagtpiV 206 Streptomyces virid...
1X7P_A    127 LGVLFDRPTSPGNIGSIIRSADALGaHGLIVAGHaadvydPKSVRSSTGSLFSLPAVRVpspGEVMDWVEARRaagtpiV 206 Streptomyces virid...
ERI40975  119 LGVVLDRPTSPGNVGTVARSLDAFGgSGLVVAGHaadpydPRAVRASTGSIFSVPTVRVpagRDVLDWVAAQRssgvplT 198 Bacillus sp. EGD-AK10
EYT50434  130 LVVAFDRPGSPGNIGSLARTVDALGgDALVITGRsadawdPAAIRASTGSVFAIPVVRRdshRDLMDWVGRRRetgenwQ 209 Brachybacterium mu...
EFH83742  121 LVVVFDRPASPGNLGTIIRSCDALEaHGLILTGHavdlydPETISASTGSFFALPTVRLpsqRDIEPWLQSAKkklgalQ 200 Ktedonobacter race...
EYF08202  120 LVLLLDRPTNPGNFGTTIRAAAAFGaHGIVVTGHtadlydPITVRASVGTLFSQTIVRVssnNELLPWLEGLKpripglQ 199 Chondromyces apicu...
CDA60551  114 IILLIDRPSKKGNLGTIIRSADALNvEHIYFSGHavdiydHTVITATMGSFFKMLLTFIssnNEFDKLVSDLKnkfnnlK 193 Clostridium sp. CA...
AEF82177  118 FILLFDRPGDTGNLGSVIRSANAFNvDALFVLGHaadvydPKTIRASLGSVFHTKIILVesfAELEAFIQNEKirc-giK 196 Treponema azotonut...

Feature 1        ###                  ####  ##           ### #     ####  #        
1X7O_A    207 LVGTDEHgDCDVFDfdftqPTLLLIGNETAGLSNAWRTlcdyTVSIPXAgsaSSLNAANAATAILYEA 274 Streptomyces viridochromogenes
1X7P_B    207 LVGTDEHgDCDVFDfdftqPTLLLIGNETAGLSNAWRTlcdyTVSIPMAgsaSSLNAANAATAILYEA 274 Streptomyces viridochromogenes
1X7P_A    207 LVGTDEHgDCDVFDfdftqPTLLLIGNETAGLSNAWRTlcdyTVSIPMAgsaSSLNAANAATAILYEA 274 Streptomyces viridochromogenes
ERI40975  199 LLGTDEHgDVELADhdltgPTLVVTGNETTGLSAGWREacdvMVSIPMLgsaSSLNAASATTVVLYEA 266 Bacillus sp. EGD-AK10
EYT50434  210 VVGLEEArGHQLAHtdltgPTVLVVGNETVGLSSGWREacdlLAEIPMSgsaSSLNAAIAGSIGLYEA 277 Brachybacterium muris UCD-AY4
EFH83742  201 IIGTDEKaEQEISQhdftvPTVLIVGNETWGMSAAYKElcdaVVQIPLVgsaSSLNVACATSICLYEV 268 Ktedonobacter racemifer DSM 44963
EYF08202  200 LVVSGHEgEHQIHEcnfrrPTVLVLGNETRGASTLFKDladeTARIPLEgvtTSLNVSCAASIFLYEI 267 Chondromyces apiculatus DSM 436
CDA60551  194 VVATSLQtNNRIQDydftsPVLLLIGNETDGLCRYYNEkadeKVKISMRdgiDSLNIACATTACLYEI 261 Clostridium sp. CAG:524
AEF82177  197 IYGTDTKgDMPLTEerlqrPVIVALGNEAKGISVALKNicdgIMGIPITgevNSLNVASAASIFMWEV 264 Treponema azotonutricium ZAS-9

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