2G9F


Conserved Protein Domain Family
PAW
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pfam04721: PAW 
PNGase C-terminal domain, mannose-binding module PAW
The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.
Links
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Statistics
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PSSM-Id: 461409
Aligned: 35 rows
Threshold Bit Score: 195.576
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2G9F_A         4 GRVSGSLAWRVARGETGLe---------rKEILFipsE-NEKISKQFHLRYDIVRDRYIRVSDNN---TNISGWENGVWK 70  house mouse
XP_011137990 421 GRTSGSLVWRLARGELMSadkdylnkcmyKDYIW---D-VSKYGQIFELRYNIIKDIYQIVHNDGtflEQIHKWSEGINS 496
5_pfamImport   1 GRTSGSLTWRTARGETEGekrk---tlveNFKAIkstD-VELKNGKIHIEYSCSSDKYTRISDSK---TSHGGWKTFVFR 73 
1_pfamImport   1 NFYSGSEEWRLARGEMGSna-------apETPLGapiK-LTQSADHLEFSYNIVTDTYSQEPA--------KGFVSATFE 64 
EGT31835     406 GRTTGSEQWRRARGELGSvapk----ldaPKLFGkpiNlIANSENYAEFSYDIIRNIYSTSTE--------KGFISQAFE 473
XP_002427006 431 GRISGSLNWRLSRGETSNdel------nfKPFVWkidE-KDKENGKFELVYITSKDIYIKHSE-----EVLKTWKSGVYK 498
XP_015785923 321 GRSSGSIDWRVARGECSStqt------kiKNFIIkfnD-NTKDGK-YRFTYHSVSDKYFINDFQL------NGWESAVFN 386
XP_011052918 418 GRTSGSLMWRLARGEIMQad-------teKSYIW---D-ISKYGETFELRYNIVKDLYYVVRNNGtilEEKSGWLEGMNT 486
XP_011264466 414 GRTSGSLVWRLARGETEQan-------ieKNYIW---D-VSKYEQTFELQYNIVKDIYHIVHNDGtilEQKSGWQEGINT 482
XP_002122689 401 GRTSGSLAWRLARGETDKvkdgk--skmeTCEVIrpsE-DEIKSGMLTLEYSSSLDKYTRITDNN---KSYDGWKSLVYC 474 vase tunicate

2G9F_A        71 ME-SIFRKVEKDWNMVYLARKEGSSF---AYISWKFECGSAGLKVDTVSIRTSSQSFESGSVRWKLRS----ETAq---V 139 house mouse
XP_011137990 497 TCgGMFRKTEEDWKMVYLARSEGTSN---GHVTWAFKVANPQLCIETFNLKAKSQVFHGASVSWEIEAifndNKT----V 569
5_pfamImport  74 VQ-DVMRKVEYDWKRAYLCRKEKSLM---GYIAWQIELP-KTYAISVAEIFVADTIFEDGFVKWLVTT----DKTs---R 141
1_pfamImport  65 CE-NIKRVEENDWKFVYLCRKDGAKE---GNISWHFDLE-------SI-----GKPLEK--VEVRVAGiekfEKAk--aM 124
EGT31835     474 CK-NIQRKEELDWKQVYLCRENGKES---GEISWHINLE-------SLTAN-STKSIEK--VEIQMMGirkwEKAn--aM 537
XP_002427006 499 LN-SVFKKDEKNWKMSYLAHLEGTEK---GTVSWKFETGE-DYSIGNINLKLVSQIYEKGIVVSKLQT----DTTs---V 566
XP_015785923 387 FD-NIFKKVEKDWNMIYLSRQENSDCskkGTLTYKFDVR---FNWTAMIIKINTKVYDTGRVSILLTS-----EPeflnK 457
XP_011052918 487 MEgGVFRKVENDWKMVYLTRSQQAKH---GSVKWTFEIPNSKSCLETLTLKAKSKVFQNAMVSWEIEAifdnDRA----V 559
XP_011264466 483 TDgGIFRKVEDDWKMVYLARSPDAQC---GRIKWTFKIANSKLYLETFNLKAKSEVFHEASVSWKIEAvfsdDKV----I 555
XP_002122689 475 HQ-DVMKKVEQDWKQTYICRKEDTSV---GYISWRVELP-NTCLLTHVELCVKDSVFEQGHVSWLLTT----DKTt---H 542 vase tunicate

2G9F_A       140 NLLG-DKNLRSYNDFSGA-T-------EVTLEAELSRGDGDVAWQHTQLFRQSLN--DS-GENGLEIIITF 198 house mouse
XP_011137990 570 TIPItQCTSFHTKKVEKA-M-------RLNLHVILSGGKDESAWQHAQLFRQSLE--DT-EEPSMIITIQL 629
5_pfamImport 142 SIKSgSSEKLELLNTKSR---------VLSIHAFLRGEN----WQHSQIFREATG--SP-SSPSLKLQIEF 196
1_pfamImport 125 VMAClGDTCMKISSKTGLlTidnptagILKISAALFGGEGSIAWQQAQIFRTKLD--EK-NGESLQIKVWT 192
EGT31835     538 VIAClGDTCMKIPANGNL-TidepstgILKITANLIGGEGDQAFQHAQIFRTESDtdDE-RTNSLLVKIWL 606
XP_002427006 567 IIPN-DSKMLSTDAFSGC-K-------SVELIVELCGVN---FWQHAQILRQSFF--A--EDSTLHIVISL 621
XP_015785923 458 EIDPdSVNGLKKSCLKKDvD-------YIIMTMTLSGGSGNIGWQQAQLFRQSTL--AAaTDYSLDVIFTK 519
XP_011052918 560 TISVpNCSNFHTEEVRKA-V-------RINVIVTLSGGQGQEAWQHAQLFRQSLD--NT-EEPSMIINIQL 619
XP_011264466 556 AIPIsNCNNFYTEEIQKA-V-------KLDIIVTLSGGQGQLAWQHAQLFRQSLE--NI-EEPSMIVSIRL 615
XP_002122689 543 IVKSgTTEKIDLTK-SKS-Q-------FFSIHAFLRGEN----WQHAQLFREPLN--T--SEISFNVKVLW 596 vase tunicate
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