1EXC


Conserved Protein Domain Family
Maf
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cd00555: Maf 
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Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.
Links
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Statistics
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PSSM-Id: 238310
Aligned: 93 rows
Threshold Bit Score: 161.491
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitedimer interface
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:conserved Glu and Asp might participate in the hydrolysis of the phosphate.
  • Structure:1EXC_A; binding dUTP
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #    #                   #                              #                   
1EXC_A        5 LILASQSPRRKELLDLLQlpYSIIVSEVEEKlnrnf------------speeNVQWLAKQKAKAVADLhp---------- 62  Bacillus subtilis
ZP_00113504   2 LMLASASPARRRLLQQAAipHQVMVSGVDEEtihhf------------dpvrLVQHLAEAKAGVVHQQik---------- 59  Prochlorococcus ...
P74331        5 FVLASASPARKRLLEMAGisPLVAVSHFDESslaad------------ntvaLVEALAKAKAGTVASKfa---------- 62  Synechocystis sp...
P58632        6 FILASASPARRRLLQTVGiePIVSPSDFDESqiqet------------epgkLVQILAQCKAETVAPQfp---------- 63  Nostoc sp. PCC 7120
NP_696441     5 LILASKSKPRRDVLYSAGicPTIRVSHVDEPaaleaaareegvtvddlsikqRVMILAVAKAEAVHRAyrdvadtaaaat 84  Bifidobacterium ...
ZP_00115913  33 LLLASASPARLRLLELAQipHRVRVSGVDESsienh------------dpalLVQQLALAKATAVSDGida--------- 91  Synechococcus sp...
ZP_00072607   6 VILASSSSARLRLLKTVGinPIVMPSNFDEStiklk------------eprqLVETLAQAKAETIANSimkekl------ 67  Trichodesmium er...
ZP_00105123   2 LILASASQSRKKLLENSQieFIQISSNFDEAlvkek------------disnLTLELSFQKASRIALNiqeidlp----- 64  Prochlorococcus ...
NP_682092     4 FVLASASPARRQLLQQIGidPIIQPSHFDESviqaa------------tpteLVRLLARCKAETVAQSys---------- 61  Thermosynechococ...
NP_599937     3 IVLASQSPSRRRILNSAGvePLIHPADVDEDallhsln--------gsapeeIVRQLALAKAQVVAPSyp---------- 64  Corynebacterium ...

Feature 1                                                                                       
1EXC_A       63 ---------------------------------------------------------------------------hAIVI 67  Bacillus subtilis
ZP_00113504  60 --------------------------------------------------------------------------aaLPVL 65  Prochlorococcus ...
P74331       63 ---------------------------------------------------------------------------dALVL 67  Synechocystis sp...
P58632       64 ---------------------------------------------------------------------------sGLVM 68  Nostoc sp. PCC 7120
NP_696441    85 gdrviayplkakeikdsereaavedlreaaagkpidyskaeiattrdfsgidmptvtepiataiagqpglteatvgPLIL 164 Bifidobacterium ...
ZP_00115913  92 --------------------------------------------------------------------------diSSVL 97  Synechococcus sp...
ZP_00072607  68 -----------------------------------------------------------------------pekqsNLIL 76  Trichodesmium er...
ZP_00105123  65 ---------------------------------------------------------------------ekfnyssVEIL 75  Prochlorococcus ...
NP_682092    62 --------------------------------------------------------------------------apALIL 67  Thermosynechococ...
NP_599937    65 ---------------------------------------------------------------------------gDVVI 69  Corynebacterium ...

Feature 1         #           #                                                                 
1EXC_A       68 GADTMVCLdGECLGKPQDQEEAASMLRRLSgrSHSVITAVSIQAe-----------nHSETFYDKTEVAFWSLseeEIWT 136 Bacillus subtilis
ZP_00113504  66 GCDSVLEFdGTVFGKPATAVEASSRWQRMAgaWGFLHTGHCLLSvn----------gERLSETVTTRVLFAALsdsEIEA 135 Prochlorococcus ...
P74331       68 GCDSLLLVnGQTYGKPESPAVAIARWQTMRgqVGELYTGHALIDrt---------qnRCLCQTGLTKVHFADVdddTIQA 138 Synechocystis sp...
P58632       69 GCDSVLAIdGKIHGKPIDADEAIARWQLMRgqVGDLYTGHVLIDki---------qnRTLVKYQVTKVYFANIsdrTIQA 139 Nostoc sp. PCC 7120
NP_696441   165 GCDSMFLLgGECYGKPHSEAVASERLKRMSgaTGELWTGHCLIDfa---------tgRTVRGASHAKVHFGEFtdaDVER 235 Bifidobacterium ...
ZP_00115913  98 GCDSLLLFeGEVFGKPQDGEEAAARWRRMAggSGELLTGHALLVrs----------gENRLACISTRVHFAAIteeEIQA 167 Synechococcus sp...
ZP_00072607  77 GCDSVLVIeDQIYGKPNDKQEAITRWQKMRgqVGQLYTGHALIDls---------qnKTIVLCRMTKVHFSHVndqEIEA 147 Trichodesmium er...
ZP_00105123  76 GCDSIFEFnGRPFGKPSDKDEAYRRWSQMSgeFGFLHTGHTLLFstfdssskilkvtKKIKKTVSSKVYFSKLqdeEIKN 155 Prochlorococcus ...
NP_682092    68 GCDSVLVLgGEIYGKPASPEMAIARWQQMRgqTADLLTGHALIDla---------qgRTCVEVESTQVVFAQVsdaEIAA 138 Thermosynechococ...
NP_599937    70 GGDSMLLIdATLQGKPHTREATIERWKQQRgnKATLITGHAIIFg-----------dEVIVESSSTNIHFAEAsdvDIER 138 Corynebacterium ...

Feature 1                                                     
1EXC_A      137 YIETKEPMDKAGAYGIQGrGALFVKKIDGDYYSVMGLPISKTMRAL 182 Bacillus subtilis
ZP_00113504 136 YVATGEPLLCAGGFALEGqGGLMVERLEGCFSNVIGLSLPLLRRWL 181 Prochlorococcus marinus str. MIT 9313
P74331      139 YVGSGEPLQCAGAFALEGkGGMLINKLDGCSSNVIGLSLPILRSLL 184 Synechocystis sp. PCC 6803
P58632      140 YVATGEPLKCAGAFALEGfGSLFIEKIAGCHSNVIGLSLPLLRQML 185 Nostoc sp. PCC 7120
NP_696441   236 YIATGEPLEVAGSFTLEGfGGAFIDSIEGDPHGIIGLSLPLARHLA 281 Bifidobacterium longum NCC2705
ZP_00115913 168 YVTTGEPLHCAGGFALEGrGASLIAGLEGCYSNVIGLSLPWLRSVL 213 Synechococcus sp. WH 8102
ZP_00072607 148 YVATEEPLKCAGCFAIDGiGGLFIEKIDGCHTNVIGLSLPLFRVML 193 Trichodesmium erythraeum IMS101
ZP_00105123 156 YVDSLEPLYCAGGFALEGkGGKYIERIDGCFSNVMGLSLPWLRKSL 201 Prochlorococcus marinus subsp. pastoris str. CCMP1378
NP_682092   139 YVASGEPLACAGCFALDGqGGAFVEKIVGTPSNVIGLSLPLLRRLL 184 Thermosynechococcus elongatus BP-1
NP_599937   139 YADSGEPLECAGAFTLEAlGGWFIDSIEGDPSSVIGLSLPVVRRAL 184 Corynebacterium glutamicum ATCC 13032

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