154L,1LSP,3GXK


Conserved Protein Domain Family
GEWL

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cd01021: GEWL 
Click on image for an interactive view with Cn3D
Goose egg-white lysozyme
Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.
Statistics
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PSSM-Id: 381601
Aligned: 31 rows
Threshold Bit Score: 206.682
Created: 16-Aug-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
sugar bindingcatalytic
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:154L; Anser anser anser "goose-type" lysozyme binds N-acetyl-D-glucosamine; contacts at 4A
  • Citation:PMID 7823320
  • Structure:1LSP; Cygnus atratus lysozyme binds bulgecin A, contacts at 4A
  • Citation:PMID 4062692

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                          #             
154L_A        12 DTTGASCKTAKPegl-----syCGVSASKKIAERDLQAMDRYKTIIKKVGekLCVEPAVIAGIISRESHAGkvl------ 80  western graylag...
1LSP_A        12 DTTGASCKTAKPegl-----syCGVPASKTIAERDLKAMDRYKTIIKKVGekLCVEPAVIAGIISRESHAGkvl------ 80  black swan
AEQ98812      30 PTTGASCLTASQdnl-----pyCGVAASQQMAATDLPDMNQYKEKILAVAqnLCMDGAVIAGIISRESRAGavl------ 98  axolotl
ACM08479      12 ETSGADLRTAKAdgk-----ndEGVPASHRMAEHDLAAMNKYKGLIMKVAerNAVDPAVICGIISRESRAGtgl------ 80  Atlantic salmon
ACO07658      25 KTTGASKETADAdgha---rgySGVTASERMAEYDKDDINNYIDIIREVGkeYEIAPALICGIISRETRGGrairkpspp 101 rainbow trout
EMP27174     307 QTPTCETTFTFAf--------aTGVHAAEKMAQIDIVRLRRYEVPIKRVArnLCIDPALIAAIISVESRAGail------ 372 green seaturtle
CAF92283     199 ETSGASEDTAIAngl-----rvRGTEASNILAAKDLKKMKKFKDDITSVGqrLGVEPALIAAIISRQSQAGtnls----- 268 spotted green p...
XP_006277747  30 QTPVISCGPVKTv--------gCGVSASEKIAEIDIIHLRSYRTIIRRVAksLCLEPSLIAAIISVGSRVGhll------ 95  American alligator
XP_008434380  47 TTTGASKITKERnidsssmnrmTGVEVSKTLAEQDLELMSKYKTDIKSVGkaLRLHPALIAAIISKQSRAGgtld----- 121 guppy
Q86SG7        47 KTSGATCDANSVm--------nCGIRGSEMFAEMDLRAIKPYQTLIKEVGqrHCVDPAVIAAIISRESHGGsvl------ 112 human
Feature 1                         ###  ##                       #   #                       ## # 
154L_A        81 ---knGWGDRGNGFGLMQVDKRSHk------pQGTWNGEVHITQGTTILINFIKTIQKKFPSWTKdQQLKGGISAYNAGA 151 western graylag...
1LSP_A        81 ---knGWGDRGNGFGLMQVDKRSHk------pQGTWNGEVHITQGTTILTDFIKRIQKKFPSWTKdQQLKGGISAYNAGA 151 black swan
AEQ98812      99 ---qnGWGDNGHAFGLMQIDIRWHs------iEGAWNSQENINEGTGILINMIVAISDKFPSWSVnDNLKGGIAAYNAGP 169 axolotl
ACM08479      81 --dkhGRGDNGKAFGLMQIDTTPApsggghtpKGEWNSEEHLKQCTEILIGFIKIIQKKFHLWTKeQQLKGGIAAYNKGQ 158 Atlantic salmon
ACO07658     102 ivpkqGWGDYGRGFGLMQVDVDPNggn--hkrRGEWDSETHLEQATGILIDFINEIKDKFPDCTEeQQLKGGIAAYNQGI 179 rainbow trout
EMP27174     373 ---vdGWNRERNRYGLMQVHTHYNt------iPGAWDSEEHITQGATILITEIKALQTKYPTWSWqQYLRGGICAYHDKV 443 green seaturtle
CAF92283     269 --tsgYGVSDPNCFGLMQINKHYHa------vKGNAYSSEHIDQGVTFLIQLIKTMRRTRPDWSKeQQLKGALACYVAGE 340 spotted green p...
XP_006277747  96 ---enGWDHQRVRFGLMQIDRRYYp------iRGTWNSEEHIIQGSTILTIALKTVRKTYPRWTWaQQLRGALCAYHSRD 166 American alligator
XP_008434380 122 --ckgYGKLDSVCFGLMQIHKDHHe------lKGTAFSREHIEQGSTCLIHLIKDMKNRKPDWSEeMQLKGALVGYMTGL 193 guppy
Q86SG7       113 ---qdGWDHRGLKFGLMQLDKQTYh------pVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVaQHLKGGLSAFKSGI 183 human
Feature 1                                           
154L_A       152 GNVrsy--arMDIGTTHDDYANDVVARAQYYKQHG 184 western graylag goose
1LSP_A       152 GNVrsy--arMDIGTTHDDYANDVVARAQYYKQHG 184 black swan
AEQ98812     170 GNIysy--sqVDQYTTDGDYSNDVVARAQYYKTQG 202 axolotl
ACM08479     159 DCVesy--ekVDAHTTGMDYSNDVVARAQWFYRHG 191 Atlantic salmon
ACO07658     180 GAIhsl-ckrVDENTTGKDYSNDVVARAQWYHNNL 213 rainbow trout
EMP27174     444 RNIqvy--dgMDSCNSSNDYVNNVIIRAKYLQNNG 476 green seaturtle
CAF92283     341 ERVlalsyedLDSVTPSKDFSSDVVARAHCSQGQV 375 spotted green pufferfish
XP_006277747 167 WKIqvy--dgRDYCSGGNDYVNNVIIRAKYFKRIG 199 American alligator
XP_008434380 194 ERVplaqpdhLDSETRTKDFSNDVIARAQFFQQKG 228 guppy
Q86SG7       184 EAI-------ATPSDIDNDFVNDIIARAKFYKRQS 211 human

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