3E7W


Conserved Protein Domain Family
D-ala-DACP-lig

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TIGR01734: D-ala-DACP-lig 
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D-alanine--poly(phosphoribitol) ligase, subunit 1
This model represents the enzyme (also called D-alanine-D-alanyl carrier protein ligase) which activates D-alanine as an adenylate via the reaction D-ala + ATP -> D-ala-AMP + PPi, and further catalyzes the condensation of the amino acid adenylate with the D-alanyl carrier protein (D-ala-ACP). The D-alanine is then further transferred to teichoic acid in the biosynthesis of lipoteichoic acid (LTA) and wall teichoic acid (WTA) in gram positive bacteria, both polysacchatides. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Statistics
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PSSM-Id: 273780
Aligned: 7 rows
Threshold Bit Score: 829.015
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3E7W_A         2 KLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRisGEKKS-PILVYGHMEPHMIVSFLGSVKAGHPYI 80  Bacillus subtilis
P39581         2 KLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRisGEKKS-PILVYGHMEPHMIVSFLGSVKAGHPYI 80  Bacillus subtil...
WP_000129653   3 DIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQG-----SKK-PMILFGHMSPYMIVGMIGAIKAGCGYV 76  Staphylococcus ...
WP_003130224   2 KLLEQIFEIAKKEPDLIVLAEREQKFTYRQLFAAVSHISEQINERn-LNQR--PILIFGKNDFITLAAMLATNLRGHAYI 78  Lactococcus lactis
WP_003732429   4 SIIERIDAWAEKTPDFPCYEYAGTRLSYKELKRQSDAFGSFLLKNl-ITDKEkPIIVYGHMSPLMLVAFLGSIKSGRAYV 82  Listeria monocy...
WP_000066732   8 DMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLg-LPEKS-PVVVFGGQEYEMLATFVALTKSGHAYI 85  Streptococcus p...
P35854         4 NVITAIDRVAAEHPTRVAYDYEGTQYTYAQLKEGSDRLAGFFAES--LPAGE-PIIVYGGQTFDMVEVFLGLSKSGHAYI 80  Lactobacillus r...
3E7W_A        81 PVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQ--IQTVSAEELLENEGGs--VSQDQWVKEHETFYIIYTSGSTG 156 Bacillus subtilis
P39581        81 PVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQ--IQTVSAEELLENEGGs--VSQDQWVKEHETFYIIYTSGSTG 156 Bacillus subtil...
WP_000129653  77 PVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGE--VFTI---EDIKTSQDp--VIFDSQIKDNDTVYTIFTSGSTG 149 Staphylococcus ...
WP_003130224  79 PVDAHTPFERTEMIKSAAKPAAVLTTVELSADFEALFtdRISLELTDQILTDKLp-aLDFSKAVSGNDSNYIIYTSGTTG 157 Lactococcus lactis
WP_003732429  83 PVDVSMPVERIEQIKKAADPSMFICTEELPNNLTITGcpVLTQDQLMDALEKHFgevPDKEACVNNDDNYYIIYTSGSTG 162 Listeria monocy...
WP_000066732  86 PIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTP--MINLAQVQEAFAQGNn--YEITHPVKGDDNYYIIFTSGTTG 161 Streptococcus p...
P35854        81 PIDTHSPNERITQVQDVAHAPAVIEVAPLPITVPDVK--IIRAPALHQAEQSHAp-iHSLQHAVAGDDNYYIIFTSGTTG 157 Lactobacillus r...
3E7W_A       157 NPKGVQISAANLQSFTDWICAD--FPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSG 234 Bacillus subtilis
P39581       157 NPKGVQISAANLQSFTDWICAD--FPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSG 234 Bacillus subtil...
WP_000129653 150 EPKGVQIEYASLVQFTEWMLEL--NKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATP 227 Staphylococcus ...
WP_003130224 158 VPKGVEVSHDNLVTFTNWMNND--FMKIENNQILSQALYSFDLSIFSLYPSLTTGGTLISLSRDETTNFKLLFERLNKTV 235 Lactococcus lactis
WP_003732429 163 NPKGVQISQNNLVSFSNWILQD--FSLSQGLRFLNQAPFSFDLSVMDLYPSLLSGGTLVPLDKTITANMKDLYREIPAQN 240 Listeria monocy...
WP_000066732 162 KPKGVQISHDNLLSFTNWMITDkeFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSLP 241 Streptococcus p...
P35854       158 KPKGVQISHDNLLSYVNWNISD--FGLEEGVVAMSQPPYSFDLSVMDLYPTLVLGGTLKALPKEVTDNFKELFATLPKLG 235 Lactobacillus r...
3E7W_A       235 LNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISR 314 Bacillus subtilis
P39581       235 LNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISR 314 Bacillus subtil...
WP_000129653 228 INIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQITQEILDQ 307 Staphylococcus ...
WP_003130224 236 INTWISTPSFVDICLLDPSFTEKEHPQLVQFILCGEELTKKTAEKLLTAFPSANIYNTYGPTEATGAISSVKITKELLTE 315 Lactococcus lactis
WP_003732429 241 LDVWVSTPSFADLCLLDENFNQENNPRLTRFLFCGEVLAKKTASELLDRFPDAVIYNTYGPTEATVAVTQVKVTREIIDA 320 Listeria monocy...
WP_000066732 242 IAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLAT 321 Streptococcus p...
P35854       236 LNEWVSTPSFVEIALLDPNFKQENYPNLTHFLFCGEELVNKTAQALITRFPKATVYNTYGPTEATVAVTGMAITQAIVDQ 315 Lactobacillus r...
3E7W_A       315 SESLPVGFAKPDMNIFIMDEE-GQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDg-QIF 392 Bacillus subtilis
P39581       315 SESLPVGFAKPDMNIFIMDEE-GQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDg-QIF 392 Bacillus subtil...
WP_000129653 308 YPTLPVGVERP-----------GARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENg-QWF 375 Staphylococcus ...
WP_003130224 316 NDRVPIGFAKPGVDLKIMDK------------EIIIVGDSVAKGYFENPEKTEQAFFTVDGKPAYHTGDAGSISAdgMLR 383 Lactococcus lactis
WP_003732429 321 YPSLPLGVIKPDMRLHIVDQEtGEVLPEGEKGEIVLIGASVSKGYLNEPEKTDQVFFDYKGYQAYRTGDSGIIKDg-YLF 399 Listeria monocy...
WP_000066732 322 LKRLPIGYTKADSPTFIIDEE-GNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDegLLL 400 Streptococcus p...
P35854       316 YPRLPIGYAKPDTNVYVVDEQ-GEQVSAGTEGELMIVGPSVSKGYLNNPDKTAAAFFKAGNQRGYRSGDLVTMTAdgMVF 394 Lactobacillus r...
3E7W_A       393 CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIP-YqPNGTVEYLIAAIVPEE---HEFEKEFQLTSAIKKELAAS 468 Bacillus subtilis
P39581       393 CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPyQ-PNGTVEYLIAAIVPEE---HEFEKEFQLTSAIKKELAAS 468 Bacillus subtil...
WP_000129653 376 IQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPvY-KNDKVIHLIGAIVPTT---EVTDNAEM-TKNIKNDLKSR 450 Staphylococcus ...
WP_003130224 384 YQGRIDFQVKFNGFRIELQDIEANIQNLKEIEKAVVLPkTnDQHKVTALIAYLETEKt-fEDRAAERAFTKELKAELSKT 462 Lactococcus lactis
WP_003732429 400 FQGRLDFQIKLHGYRIELEDIENNLKKVSYIQNCAIIPkM-KDEKVDMLVAQVIPTT---HDFEKEYQLSAAIKKELKEF 475 Listeria monocy...
WP_000066732 401 YGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPrYnKDHKVQNLLAYVILKDgvrEQFERDIDITKAIKEDLTDI 480 Streptococcus p...
P35854       395 YRGRTDFQVKLHGYRIELEDVDHNLNQVSYIKQASTVPrYdKDHKVAQLIAFAVAKP---NDFDSEMKLTQAIKAELGKM 471 Lactobacillus r...
3E7W_A       469 LPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV 503 Bacillus subtilis
P39581       469 LPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV 503 Bacillus subtilis subsp. subtilis str. 168
WP_000129653 451 LPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING 485 Staphylococcus aureus
WP_003130224 463 IMDYMMPTKFVYLKKFPLNQNGKVDRKALAQKERG 497 Lactococcus lactis
WP_003732429 476 MPAYMIPRKWIYKTDFPLTMNGKIDRKSLNSEVNK 510 Listeria monocytogenes
WP_000066732 481 MMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNK 515 Streptococcus pneumoniae
P35854       472 VMEYMIPQRIIYRDQLPLTANGKVDRKALIAEVNH 506 Lactobacillus rhamnosus
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