Conserved Protein Domain Family
nickel_nikA

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TIGR02294: nickel_nikA 
nickel ABC transporter, nickel/metallophore periplasmic binding protein
Members of this family are periplasmic nickel-binding proteins of nickel ABC transporters. Most appear to be lipoproteins. This protein was previously (circa 2003) thought to mediate binding to nickel through water molecules, but is now thought to involve a chelating organic molecule, perhaps butane-1,2,4-tricarboxylate, acting as a metallophore. [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
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PSSM-Id: 274072
Aligned: 5 rows
Threshold Bit Score: 814.809
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P33590        21 HAAAPDEITTAWPVNVGPLNPHLYTPNQMFAQSMVYEPLVKYQADGSVIPWLAKSWTHSEDGKTWTFTLRDDVKFSNGEP 100 Escherichia col...
AAN68946      29 AAEQGPQLVYSWPVNAGPLDPRGYSPNQMYAQAMVYEPLVRYTAAGTLEPWLAEAWQVSDDGKTYTFTLRDGVRFSDGTP 108 Pseudomonas put...
AAN00385      28 hKLNSDKLTLAWGEDFGDVNPHRYNPDQFVIQDMVYEGLVRYGDNGKIEPALAKSWSISQDGKTYTFKLRN-AKYSDGSN 106 Streptococcus a...
BAB96256      29 EKKENKQLTYTTVKDIGDMNPHVYG-GSMSAESMIYEPLVRNTKDG-IKPLLAKKWDVSEDGKTYTFHLRDDVKFHDGTP 106 Staphylococcus ...
WP_010896744  37 EENTEKSITFSWPRDIGPMNPHVYNPSQLFAQSMIYEPLVSYTEGGELQPHLADSWTISEDGKEYTFKLREGVQFSDGTP 116 Bacillus halodu...
P33590       101 FDAEAAAENFRAVLDNRQR--HAWLELANQIVDVKALSKTELQITLKSAYYPFLQELALPRPFRFIAPsq--fKNHETMn 176 Escherichia col...
AAN68946     109 FDAPAAKANLDAVLANTQR--HRWMELVTTLDHVEAPERLTLRLVLKHPYYPTLMELAQVRPLRFASP-----QAKPGQ- 180 Pseudomonas put...
AAN00385     107 FNAANVKRNFDSIFSKSNRgnHNWFNLTNQLENYRALNQSTFEIKLKQAYSATLYDLSMIRPIRFLSDsafpkGDDTTKk 186 Streptococcus a...
BAB96256     107 FDADAVKKNIDAVQQNKKL--HSWLKISTLIDNVKVKDKYTVELNLKEAYQPALAELAMPRPYVFVSPkd--fKNGTTKd 182 Staphylococcus ...
WP_010896744 117 FNAEIVKKNFDTWIEHSSL--HSWLGVMNVLEKTEVVDEFTFKMVLKEPYYPALQDLAVVRPVRFLGEagfpdDGDTSQg 194 Bacillus halodu...
P33590       177 gikaPIGTGPWILQESKLNQYDVFVRNENYWGEKPAIKKITFNVIPDPTTRAVAFETGDIDLLYGNE---GLLPLDTFAR 253 Escherichia col...
AAN68946     181 ----PAGTGPWMRAESRLGEYDRFVRNPQYWGPKPAYGEVMVKVIPDPNSRALALQAGEVELIQGAA---GEITAGTFVR 253 Pseudomonas put...
AAN00385     187 nvkkPIGTGQWVVKSKKQNEYITFKRNENYWGKKPKLKEVTVKVIPDAQTRALAFESGDVDLIYGN----GIIGLDTFAQ 262 Streptococcus a...
BAB96256     183 gvkkFDGTGPFKLGEHKKDESADFNKNDQYWGEKSKLNKVQAKVMPAGETAFLSMKKGETNFAFTDDrgtDSLDKDSLKQ 262 Staphylococcus ...
WP_010896744 195 i-kePIGTGPWMLSDYKQDEYAVFTRNPNYWGESPKIDKVTVKIIPDAETRVLAFESGELDLIFG-E---GVISMDAFNQ 269 Bacillus halodu...
P33590       254 FSqNPAYHTQLSQPIETVMLALNTAK--APTNELAVREALNYAVNKKSLIDNALYGTQQVADTLFAPSVPYANLGLKPSQ 331 Escherichia col...
AAN68946     254 LR-DQGYATALSAPLATRTLAMNTGR--GATRDLAVRQAINEAVDKQAIIDKILYGLEPRADTLFASNMPYADIGLKPYP 330 Pseudomonas put...
AAN00385     263 YTkDKKYVTAISQPMSTRLLLLNAKE--SIFQDKKVRQAMNHAIDKVSIAKNTFRGTEKPADTIFSKSTSHSDAKLNPYS 340 Streptococcus a...
BAB96256     263 LKdTGDYQVKRSQPMNTKMLVVNSGKkdNAVSDKTVRQAIGHMVNRDKIAKEILDGQEKPATQLFAKNVTDINFDMPTRK 342 Staphylococcus ...
WP_010896744 270 LKeSGQYGTDLSEPVGTRSLLLNTSN--EKLADLRVRLALHHGFNKQAMVEGVTLGLEEKADNILSTNFPYTDIDVEPIE 347 Bacillus halodu...
P33590       332 YDPQKAKALLEKAGWTLPAGKDIREKNGQPLRIELSFIGTDALSKSMAEIIQADMRQIGADVSLIGEEESSIYARQRDGR 411 Escherichia col...
AAN68946     331 YDPARAAHALDAAGWTLAPGASVRSKGGEPLAIELVFLGTSALQKSLAEVLQGELAKIGIHIDLRAVEEGALVRRQRDGD 410 Pseudomonas put...
AAN00385     341 YNVDKANQLLDQAGWKMGKDK-VREKDGKTLTLRLPYIATKATDKDLVTYFQGEWRKIGINVSLIAMEEDDYWANAKKGN 419 Streptococcus a...
BAB96256     343 YDLKKAESLLDEAGWKKGKDSDVRQKDGKNLEMAMYYDKGSSSQKEQAEYLQAEFKKMGIKLNINGETSDKIAERRTSGD 422 Staphylococcus ...
WP_010896744 348 YDVEQANAYLDEAGWELPAGKTVREKNGEQLELELIYDKTDPLQKAMAETMQAEWAAIGVKLDITGLELTTQIQRRRAGD 427 Bacillus halodu...
P33590       412 FGMIFHRTWGAPYDPHAFLSSMRVPS---HADFQAQQGLADKPLIDKEIGEVLATHDETQRQALYRDILTRLHDEAVYLP 488 Escherichia col...
AAN68946     411 FGMIFADTWGAPYDPHSFVSSMRYAG---HADYMAQRGLAIKDELDKRIGQVLASTDEQQRAEQYRFILTTLHEQAVYLP 487 Pseudomonas put...
AAN00385     420 FDMMLTYSWGAPWDPHAWMSALTAKAdhgHPENIALENLATKTEMDRLIKSALVDPKEENVDRDYKKVLELLHDEAVYIP 499 Streptococcus a...
BAB96256     423 YDLMFNQTWGLLYDPQSTIAAFKAKN----GYESATSGIENKDKIYNSIDDAFKIQNGKERSGAYKNILKQIDDEGIFIP 498 Staphylococcus ...
WP_010896744 428 FDVDFWYNYGAPYDPHSFINVVAEAG---WGVAEAHSNLSMKEELDEQVRATLASTDETERQELYGSILNTLQEQSVFVP 504 Bacillus halodu...
P33590       489 ISYISMMVVSKP-ELGNIPYAPIATEIPFEQIK 520 Escherichia coli K-12
AAN68946     488 ISHLTAISVRRD-SVAKVQFGSTLFDVPFETMT 519 Pseudomonas putida KT2440
AAN00385     500 LTYQSVISVYRKgDFKTMRFAPEENSFPLRYIE 532 Streptococcus agalactiae 2603V/R
BAB96256     499 ISHGSMTVVAPK-DLEKVSFTQSQYELPFNEMQ 530 Staphylococcus aureus subsp. aureus MW2
WP_010896744 505 ISYIKKTVVYQE-NVNEFIFPANRDEHPFNGID 536 Bacillus halodurans
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