Conserved Protein Domain Family
Dsl1_N

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pfam11988: Dsl1_N 
Retrograde transport protein Dsl1 N terminal
Dsl1 is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum. It is localized to the ER membrane, and in vitro it specifically binds to coatomer, the major component of the protein coat of COPI vesicles. It is comprised primarily of alpha helical bundles. It complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein. A central disorganized region between the N and C termini of Dsl1 contains binding sites for coatomer. The C terminus of Dsl1 contains a binding site to the Sec39 subunit of the Dsl1p complex.
Statistics
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PSSM-Id: 403266
Aligned: 13 rows
Threshold Bit Score: 375.461
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD25729      12 NKDELISSIKDD----LLLLQNKNNITttgndaeddlnvskmDKTPDVNTILTKETQLATELHDLQQLKTISSLIMEFKT 87 
CAR28976      14 SKAEILESLGKD----PLLVNEKESKSdn-----------kdDTPVDFEGILKRESSLNQELHDLASLRSISGLIMEFKA 78 
CCE91492      19 DRNGILHQLEDD----PVLINDELREP----------------SKIDTDAILKREMGLSRELREYTALKTVPSLVLEFKT 78 
EDO19082      13 DKERLLQLLRND----PLLSLNDDVEI---------------TEKIDLEGLLKLDASLTEELHVLNSLKTIPSLILEFKA 73 
CCE62102      12 NEQSIKESLLQD----PLLFRNKSGDSvds----------nsNELLSFESVMNKDTALVAELHDLNSLKQISDLILEFNA 77 
Q6FNZ0         5 DKDHVITELLKD----PVYLSRHNSLA---------------THPKDENDLYALETKLEEELHDLKDLKIVSSLVKETQV 65  [Candida] glabrata
XP_003673020  14 NRDALIQSIEQNletpPLTATHDGNSS---------------TQELNRGQLMMKEEQLSSQLHDLNNLKILSGLLIEFKT 78 
CCF58034       7 DRETLISLVEQN-----LILKNKNTID---------------DPSLEMNKILEEESKLSEELRDLTKLKTISSLLKEVNV 66 
CCK70726       8 EREEVLLSVERD----PIFQGENGADVaas---------nytQLTERIREVVAQEAQLGSMLHDLSVLKTFGDLLNEFNT 74 
CCH58355      24 NRDILVASIKND----IESTIEDSPTQppti-------ethiKAHIDPFVIQQEDTQLSNDLYELNKLKTITSLIMEFKT 92 
XP_002554331  25 DQDAILAGIESD----PNLKMEGSARR---------------EEPSDVQAILNQDVQLSKKLGALKELNLVANLIDEFKA 85 
Q6CUS2        14 DTSALSQAIEAD----PQFKSSDSVHPk--------------PNSKLLEEVLREDSDLTKDLAKYNQYKILSDLLKEFNT 75  Kluyveromyces l...
Q752C3        47 NPMQVLAAIEDD----PSLWLDSSEKK---------------PNHLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNS 107 Eremothecium go...
CCD25729      88 NFELFELENCFYSLQSLRKQIGtitinnNNPSFARQNYHFQRSVIVYIDSLHLDLISRIFEIITLKFWNI-------T-S 159
CAR28976      79 NFELLELENCYYSLQNLRKKLR------DTSSLTKQSFSFQQSVFSHVDTMHLQLVGKLYEIISQWFWQV-------N-G 144
CCE91492      79 NLHLLEFENSFYSLQTLRKKLR------DFSEILSQSYGLQRSVATYVDNMHLDLVNSLYSILNDGFWKI-------G-S 144
EDO19082      74 NMEYLELENCYYSLQNLRKKLK------ENDTLVRQNIRLQQSVATYVDSLHVQLVDKLFDLISNHFWNF-------K-E 139
CCE62102      78 NWEYIEVENCYYSLLNLRKKLKq-----NDTVLAKQNIRFQQSVITYVESLHLKLIEKVSDLLTEKFWNI-------T-S 144
Q6FNZ0        66 NLDLMELENCYYSLYNLSKKLK------SSRSFLKQSLHFQRSVAVHVDELRIKLLSTIYDILATKFWSI-------S-E 131 [Candida] glabrata
XP_003673020  79 NFELLELENCFYSLQSIRKRINg----nNNSSFLKQSFHFQRSVAVYVDTMHSTLIDKIFEIITTKFWQI-------NdT 147
CCF58034      67 NFELLEFENCYYSLKSLRSKLTe-----NNSVFIKQTYRFQRSTALYIDSLHSKLIDSIHEVITTKFWNI-------T-S 133
CCK70726      75 NLAKSLFQDCYRALQTLRQKLNt-----SRDCFVKQPLHFQRSLMNYIDELHLTLIERIYEIISTDFWSV-------T-H 141
CCH58355      93 NYELMEYENCYYSLQNLRKKIH------ENEPILVKNYHLKQSLSSYADGLHVQLIEAIHSLVSKGFWKIptvsasdNqN 166
XP_002554331  86 NFELWELENCYYSLQNLHKRLEk----vDMSLFPIQ---FQGLLKVHIDSLHVDLLSRIDKVMRQ-FWDI-------S-A 149
Q6CUS2        76 NYELNELENCYYSLQNIHKKFK-------DVNISGESFRFQQSVATYIDCLHLNVLERFKEV-SNMFYTI-------S-G 139 Kluyveromyces l...
Q752C3       108 EIQCAEFTAAFETLRQCVQKAK-------SADVSAHGVRFEQAFNTYLSGLHAVFVRKLQGLLEE-VWHI-------H-D 171 Eremothecium go...
CCD25729     160 ESISFNPKLnvqTTDGLDVEIAYDSFISSIKNLYF--PNDIIDSEFWIISNVELND-LHESIRNKLQTIFKDYINLDGVS 236
CAR28976     145 DSITFKRLV---ELGEDSETMEYVPFITFVEQQYY--PDGFLDPDLWVIRHMKVGS-SQDTVVENLNSILRDYLNSNLMI 218
CCE91492     145 DFVSFQEKV---AFGNDRVDIDYVDFMASMVSLYF--PQGHLDPKSWIISDMILGT-MQETVRAKLDFILKEYVKLSGVT 218
EDO19082     140 HTISHKDEI---VYGKDKVKFDYETLLEFVNRDIF--PQNVLDFEHWLIKDMVMGD-LQEIVRERLSTIVKSYILFDSII 213
CCE62102     145 NSVVYNASV-----ELNNVKFEYKPFLEFLSNELIieNDNILDLNNWFIKDMSLGE-LHNMVRNKMKIILNDYLHFELLL 218
Q6FNZ0       132 SSFEFHPDI---KWKEEEFMMKYEEFKSFVSKSFF--PDNAINNSHWLITDIIHSE-EQERMRNKLKDIYINYIDFASLT 205 [Candida] glabrata
XP_003673020 148 GSIAFHKKI---TYGPEDIDLEYESFIDFVKQQYF--PQNVLDSQLWIISDMDIND-LQENVRGKLQTILKSYIHLNVVI 221
CCF58034     134 NTIKFNPKI---KIGDDDVQFDYTEFMSFAKSSFF--TKDTSSSEFWFLATMELGD-YKENVRSKLNDINRNFIEFNNII 207
CCK70726     142 DSITFHNKIv--CSEGSGGQFEYRQFMELVKKLFFwdDGEISTEDTWFLKDMDLNNpSSNIVRNKLSEISKNYLELNEIV 219
CCH58355     167 VSIEFQKII---HWGNGHIEFEYEFFIDFLRDALF--PDSKFDLQNWLITELVSTD-LQQIVKDNMDSLFNEYIQFSTLV 240
XP_002554331 150 RSVTFNQKI---AVDRDDVLLEYDSFSLFLKSCFF--SQDHFEPTSWFVATMNMGD-AKDKVTNLLATAFNEWVRLQTVQ 223
Q6CUS2       140 NEMMFKKTI-----ELDSVEFNFDEMVELFENNFF--DHNMIDQTHWFIASTNLET-YKDKEIVLLQEILDDTVKLNPLI 211 Kluyveromyces l...
Q752C3       172 DGFSFQQQVsekLDDAREHNFDYDTLVDMFNSCFL--KDGDIDERSWFFKNISMPD-VRDDVKQCVNSTYNNYIKLSQVK 248 Eremothecium go...
CCD25729     237 AMIKNAIFTNNKQFKYANNKLsiISSLTS--------MNQTDFLTTTIESFQNIITFLNETLPLQDRNILLSKLGNTITT 308
CAR28976     219 ETIKRFLFAKGGKITWEDLGNt-QKLHFK--------QSGTDKVGERISNILNVVSFLNEGITPHDKHALAEKLGPLLAN 289
CCE91492     219 NLIKSCIFAQSSEALLEDNNKtlKFRQSS--------KKGDEKFKETLSSFKNVLQFLTETVVSQDKKILAERLGPSIST 290
EDO19082     214 HDVKENIFNDKGIFTYDEDSKklSLVDSR--------SKDLDLLTEKLVGFGKLADYLLSCISKRDVVILSSRIGPSIAK 285
CCE62102     219 NKLKEALFNSNMKFDYDVNNR--KLSWEE--------NYHDVKSKDKLESLTNIVNYMNTELSELNSK-LIEKLSPLVAN 287
Q6FNZ0       206 KAVKDALFSDEYEFEWSDNNY--TKLLIT--------KRGALCIQKRIESFNNLLSFLEKGISNSDKFKLLTNLGKAIGI 275 [Candida] glabrata
XP_003673020 222 DRIKKSIFTKGKMFDYELGKLlfKDVSNI--------TDNQSLLQETIASFTSLVRFFQDILIEDDCITVLTSLGNVISN 293
CCF58034     208 GSIKNLIYDDSVNVTYSTQDN--ILSFQK--------GESNDYLEKIIEKSQAIVNFLTETFLPNNLYVIVSEVGSLLST 277
CCK70726     220 VNLKRGIFDNSIKFEFQAESCtlSFTKVKnaipnssgSYNKAALASVVESINALADFLMQCIDGNDLVIILSKLGPLLSN 299
CCH58355     241 HVLKTGIMNRNYSIVLTGEASniINLQTK--------LNSKSSIQDYLYSLENIIEYLKNTLLERDSITIFNQIGNYFFN 312
XP_002554331 224 EKLKQFLFSANVCLSLK------GCTLGA--------SENPGNLDDTLKSFEALVMFMKDVTTAEDTAVILAKLGNTLLT 289
Q6CUS2       212 KFFKEFVFDEKCIMVRAE-----PGKLTL--------ATSEYNSLDQIKSYQTLTTFIENDLSKHAKESVMIHFGNVLLT 278 Kluyveromyces l...
Q752C3       249 ENLKGFLFSDSLRISCS------GTRLHV--------DQGCETPAAKVESYVVLADYLLNVLSPVASNQILMTLGGAIVT 314 Eremothecium go...
CCD25729     309 ELLKFVKVNISKILNNENSNLmKDQTLKINTELITFAKHftlsssshsglnNFKNYDGQQIIELLNNNRIYYNLLLDNSL 388
CAR28976     290 DLLQSVRSNAYSVLHSSDSPL-REEVSLVNEKLKFLSND------------TRWNYQSNDVEDLLNDDQVHKNLLLDGVF 356
CCE91492     291 ELMKSIKANASIIFRPENTHL-RDESLAINLILKDLSENs-----------DIWSYNGSELERLFSNSDIPTNLQVDKIL 358
EDO19082     286 ESHKLIKENISSILQEQSTSI-KNLILELNDKLLSLSNAt----------nGVWNYSGNETEELLNDKQIYNNLLLDKIF 354
CCE62102     288 EFTKLVKGNISEIVQNENL---STTVLTLNESINNLKSFtq---------tASWYFDTAVINDLLKSKEVYNNLILDQIL 355
Q6FNZ0       276 EFLRFVKSNATGIIDKNANSI-KQQTLLLNDRLKTISEQs-----------GAWNFDSDQISKLLNDEILYKSLLLDGVL 343 [Candida] glabrata
XP_003673020 294 ELTKLVKQNASVILND-NSPL-KDRIIEVSKSLVKLADRt----------kNQWHFNDSEILNILNNEQIYFNLMLDKKF 361
CCF58034     278 ELFKTAKSNASQLLRDRKNPL-IDLVRSINSSLIKLSNEi----------kSNWKYNGSDIDHLLNDEKVYINLLIDKTF 346
CCK70726     300 ELLNFLRKNATVILRDSDPSI-REGIVLINNRFGVLASKs----------nGFWNHNRNDIEHLLNDKQLYINLLVDDAF 368
CCH58355     313 EIIKLIKSNTYIILEDDGNDIlKSQISKICNTLSFLSKRn----------tSIWKFDEDEITHLLNNRQLQSNLLVDKLF 382
XP_002554331 290 EIVKFVKQNSSHLFAPGTNY--KNSVVSLNTMLTELSHKg----------gKSWQYAGRELDNLINDDSVINNLMLDKLL 357
Q6CUS2       279 ELLKIIRANPELLSNDKEQT--TEIISSIHDSLTKISEE------------TEWAYDGFELNRILKDENIYTTLKFESMM 344 Kluyveromyces l...
Q752C3       315 EATKLLKQHSKELLSKEANQ--KKDLAHFNDTLVKLSSRk----------gSSWTYNGNALDKLLNDPETFATLMFEQHV 382 Eremothecium go...
CCD25729     389 YDQIKQMR 396
CAR28976     357 ENYALKIR 364
CCE91492     359 QDQLTELR 366
EDO19082     355 EEQVNRIR 362
CCE62102     356 ESHLEQLR 363
Q6FNZ0       344 GRAISDVR 351 [Candida] glabrata
XP_003673020 362 NEALEYMR 369
CCF58034     347 DAEIKMLR 354
CCK70726     369 AKTFKEIR 376
CCH58355     383 ETKITTIR 390
XP_002554331 358 QEQISAIR 365
Q6CUS2       345 QQRVIQIR 352 Kluyveromyces lactis
Q752C3       383 HLHLLKLR 390 Eremothecium gossypii
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