4F48,4AFY


Conserved Protein Domain Family
EAL
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pfam00563: EAL 
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EAL domain
This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.
Links
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Statistics
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PSSM-Id: 425752
Aligned: 63 rows
Threshold Bit Score: 112.796
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4F48_A               12 VEQLREA---L--IGDGFLLHYQP-VLN-LQGEPleLYQAFLRL-ERNGE-MMSPNAFMAIAEEHDLITEIDRWVVARAI 82   Xanthom...
Q21G90              340 AAKIEKG---L--QGREFSTVFQSyYCDdDSNPL--YAEAFSRWrSTSLG-NVAPREFLPALSQNSMLDELTKQVLANVA 411  Sacchar...
BAF69323            490 LETRSKFdfdKgmKNKEFIVYYQP-IID-TKQGSvfGFEALVRWnLYHKDlLV-PSAFLSYIKSf-------ETLLKLHK 559 
Q1H053              434 RQELRKA---I--ENGEMALYFEP-RMD-MAGGTitGLEVLPRWlHPTKG-AIPAATFAPMAENMGLINDINTWVLEQSC 505  Methylo...
Q13KE1              103 ESRVRQG---L--SAGEFHLVFQG-AYR-AASGTlaRLEAQLRWkHPDYG-LLLPALFMTALGHPQLALDMALFVVDGVC 174  Parabur...
SDU_Lin:LFML04_0977 559 rleLVSS---V--RENRFIFHYQP-QVE-LRSGKvvGAEALLRWnHPAKG-LLEAGSFIKTLEDCDVILETEQWGLEEIL 630 
Q31RU9              324 DRDWQQA---I--AAGELTLALQP-QMG-LRNRQlrGFEVQLRWqHPQQG-TLLASQLMEHLEQSQHRETVGRWFLDQAG 395  Synecho...
Q21JH1              661 ENDLRNA---I--HNNELRLAYQP-IVD-FKTGKtvFFEAYVKWrRKKLI-APTVEGFTQRPEDTGALIPAGEWMLRTIV 732  Sacchar...
Q5ZZD8              290 MNELQRS---I--ENKDLKIYYQP-IVE-LANGQivGAESSARFeHPELG-LLSAEKFMPLIEGTSLIHNLTTLMLKEVI 361  Legione...
WP_011707890        506 EEMLARA---L--REGRIVPYFQP-VIR-LKDSRltGLEVMARWiTEEGV-LKDAFDFIPLAEQCGLIQELDYQILSHTC 577  Aeromonas

4F48_A               83 R-QLGE---Rqr-aGHKTHL--LVRIGP-NSFSDPQ---MIDTIReqlavYGVPGER-LWLQTPES----KVFTHLRNAQ 146  Xanthom...
Q21G90              412 QlQEQAlaaN----RPIGKF--SVNIST-AQLHDRI---FCENFLhwlsvNDLSSNT-ICLEISER----ESINAILACK 476  Sacchar...
BAF69323            560 FvIVQSmhdLqsfiSNGFHPyiSINIDS-NIFYHKKfieMIDEIF-----STFEHCDlVIFEIEEKglgeNR---SSNHD 630 
Q1H053              506 R-IIKDl------qGHLIHVpvYLPLTS-AQLHTPG---IQQHVAdtlnrFKLPSDA-LVLEVAEL----DFMQQPEHHT 569  Methylo...
Q13KE1              175 R-ELRGc--Laa-nLPLPPV--AIAMPAhVALHES----FAGEVArvadsYGVPPRL-FEIEVSDS----AEAAKLLTLR 239  Parabur...
SDU_Lin:LFML04_0977 631 R-QSDLwsrQ----GLNLHI--RMNISC-RSLLSGR---FPSDLKnafgrYPRLSPSlLELDISDT----KLFRDIRKVK 695 
Q31RU9              396 Q-LLSQwr-----nSAQFSGlfALSLLP-QQWKSPS---FIHDLRslletYQIPPEQ-LELDLPAQ----SLAESAAESW 460  Synecho...
Q21JH1              733 Q-QLTDw--Sl--mHEPTPI--SVNLSA-RQFETAS---LLERVInil-qsSPAAKNkICIEVKES----FLDSNTLHAS 796  Sacchar...
Q5ZZD8              362 K-QLAAw------hDAGHKIfvSANLSVnRGLPD-----LIEKLLn---dYEIAPQF-LKLEFTER----TCLAEQMVTS 421  Legione...
WP_011707890        578 Q-QLKEwlpLs--gQSKFKV--AINLSG-KHLVSHE---QIMKLVeiiesEGIAPGY-LIFEFNER----ELSRQDSDAL 643  Aeromonas

4F48_A              147 --QFLASVSAMGCKVGLEQFGSGLDSFQLLAHFQPAFLKLDRSIT--GDIASARESQEKIREITSRAQPTGILTVAEFVA 222  Xanthom...
Q21G90              477 --SNIHFLHQQGISFALDNFGTGNTAMTQLADLPIDYLKIDRAIT--QNIDTNKPMQALSSSVIKMAHKLGIKVVAEGIE 552  Sacchar...
BAF69323            631 ifEVCKK---HGIKILIDNFKGEYFTLTHFINFPFDFIKVDKSLIinAIQ--DIENFAILEGSYAVAEAFLKDVIALGVE 705 
Q1H053              570 --DLLKQLPAISLKISLENFGTRFSSLPYIQHLGLKILKLDHSFT--RELLSNPKARAIAGAIIELAHAQHLKVVAEHVS 645  Methylo...
Q13KE1              240 --TLTESLRDIGVSITLGNWGNGGSSMALLGGLDVDTVTIARELM--ATVPRDARAGTVMTALIDLLHALDVRVVVSGVD 315  Parabur...
SDU_Lin:LFML04_0977 696 --TIVDECRKTGVSLSIGNIGSEQGAFSYLQTLGIDRVTIPRNFV--HNLENSPRDMAIVASLITSARLLLVHAVGEGIE 771 
Q31RU9              461 --DWVYAVRDLGIGIGLADFGSRSIGLYDLRNLPLTTLKLERRFV--RGLPDDANDRAIVRGVVAMSQALKVRIVARGVD 536  Synecho...
Q21JH1              797 ----MDRLKSIGCDVLVEGFANGLADCASLNALPIKIIKLHPNIT--NTIDQGDAYQAFAKASIDLLHSFGFKVVAQGIQ 870  Sacchar...
Q5ZZD8              422 --EVFERLSTMGIKLCIDDFCSENSSFIYLTDFPIENIKVEKSFV--LKIAKDAKKAKIVEAIVKLAQTLGWEPLADGIA 497  Legione...
WP_011707890        644 --TSLHELRAKGIQISLDDFGTGFSSLNALFHFPVDYIKVDDSFT--HRMLQSPKDLALIRAMRDICQDLDFTLVVEGIE 719  Aeromonas

4F48_A              223 DAQSMSSFFTAGVDYVQGDFVAPT 246  Xanthomonas campestris pv. campestris
Q21G90              553 TQEEFYVLRAFDCDFYQGFYFGQP 576  Saccharophagus degradans 2-40
BAF69323            706 TSDIIPTLNEIGIHYIQGYEIAKP 729 
Q1H053              646 NEAERNTLLSLECNEIQGYFCANP 669  Methylobacillus flagellatus KT
Q13KE1              316 TEEQLQWLRRWPEVLVQGALVSRP 339  Paraburkholderia xenovorans LB400
SDU_Lin:LFML04_0977 772 TEQEGLHLLQWGCQIGQGNAISPP 795 
Q31RU9              537 TVDQAKFLARAECDAMQGLAYSAP 560  Synechococcus elongatus PCC 7942
Q21JH1              871 TRRQLKTLIALGCDFGQGEYFSEP 894  Saccharophagus degradans 2-40
Q5ZZD8              498 DQNALEKLRDLGCLYGQGLYFSRA 521  Legionella pneumophila subsp. pneumophila str. Philadelphia 1
WP_011707890        720 NQQQLQKLIDLGCLMGQGRYISPP 743  Aeromonas
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