4BRK,3AAR,4BR4,4BR9,4BRE,4BRG,4BVO


Conserved Protein Domain Family
ASKHA_NBD_Lp1NTPDase-like
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cd24038: ASKHA_NBD_Lp1NTPDase-like 
nucleotide-binding domain (NBD) of Legionella pneumophila ectonucleoside triphosphate diphosphohydrolase I (Lp1NTPDase/Lpg1905) and similar proteins
The family corresponds to a group of proteins similar to Lp1NTPDase, which is a structural and functional homolog of the eukaryotic nucleoside triphosphate diphosphohydrolases (NTPDases) that control the extracellular levels of nucleotides (NTPs). Lp1NTPDase contributes to host-pathogen interactions through its NTPDase activity. Unlike most of the mammalian NTPDases, Lp1NTPDase is soluble and does not require membrane association to regulate its catalytic activity.
Links
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Statistics
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PSSM-Id: 466888
Aligned: 16 rows
Threshold Bit Score: 423.682
Created: 25-Jan-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotide binding site [chemical binding site]
Evidence:
  • Structure:4BRK; Legionella pneumophila Lp1NTPDase in complex with MgUMPPNP, contacts at 4A
  • Structure:4BRE; Legionella pneumophila NTPDase1 in complex with Mg bound adenosine 5'phosphovanadate, contacts at 4A
  • Structure:4BRG; Legionella pneumophila NTPDase1 in complex with MgGMPPNP, contacts at 4A
  • Structure:3AAR; Legionella pneumophila Lp1NTPDase in complex with AMPPNP, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #### #                                                                 
4BRK_A         9 HSCIAVIDAGSTGSRLHIYSYDTDdtn---tpiHIEEIWNKKIKPGFasiqpnSVTIDAYLTMLLADApi---------h 76  Legionella pneu...
4BRG_A         9 HSCIAVIDAGSTGSRLHIYSYDTDdtn---tpiHIEEIWNKKIKPGFasiqpnSVTIDAYLTMLLADApi---------h 76  Legionella pneu...
4BVO_A        14 HSCIAVIDAGSTGSRLHIYSYDTDdtn---tpiHIEEIWNKKIKPGFasiqpnSVTIDAYLTMLLADApi---------h 81  Legionella pneu...
WP_016211932  26 TQCALIIDAGSSGSRAHLYQYDLNksh---fgkVAEFGKAAKLSPGLsi--isADKAPDYISELLKKVnipnsc-ysdas 99  Piscirickettsia...
OGT26545      22 AQYFAVVDGGSSGSKMHLYSVEDGkiteitpkgIKATTALSRLATDSasvsqfVTTLTNQIANVVDKNhtv------tps 95  Gammaproteobact...
OGV18485      28 AEYMAIVDAGSSGTRVYFYKLTQKnsl---pqvEEIKLENNTLEPSVlayikwPKELSDYLDSLFKSLitvssergikte 104 Lentisphaerae b...
OGV18574      33 NSYMAMVDIGSSGSRLYLYKFQVYdkck-ppllTEIMLKNNTVAPGLytlagdTQKVTEYFEPIFNSLdaamkehniqyk 111 Lentisphaerae b...
OGV25708      32 HNCTIVIDSGSTKSQLHFFQYDKNaade-ainiEEISSLDNKVSPGLns--lyTEDVNKYLHTLFSKLql--------nn 100 Legionellales b...
OGV28427      29 GNCKIIIDAGSSGSRAHVYQYDKDaen---niiSIQEIYSNKITPGFas--vsTSGVDAYLDNLFNKIsi---------k 94  Legionellales b...
WP_152430152  20 ADTTFVIDAGSSGSRLFEYQYHHDissehglpvIDEQIQHKDIKGGIqt--vkETDLNTYIDSLFVETkt---------i 88  Vibrio aquimaris

Feature 1                ### #                                         #                         
4BRK_A        77 NIPVYFYATAGMRLLPQsQQKKYYDELDYWFRQq-----sQWQLVEAKTItGNDEALFDWLAVNYKLDtlks-vqnkSVG 150 Legionella pneu...
4BRG_A        77 NIPVYFYATAGMRLLPQsQQKKYYDELDYWFRQq-----sQWQLVEAKTItGNDEALFDWLAVNYKLDtlks-vqnkSVG 150 Legionella pneu...
4BVO_A        82 NIPVYFYATAGMRLLPQsQQKKYYDELDYWFRQq-----sQWQLVEAKTItGNDEALFDWLAVNYKLDtlks-vqnkSVG 155 Legionella pneu...
WP_016211932 100 KVQFGLYGTAGMRLLSQdAQKAIYQAIRTTLQQqpnskkfNIFPHGIRTIsGRWEGIFAWIDNNWDNAkfrl--tahTNG 177 Piscirickettsia...
OGT26545      96 EINFYIYATAGMRLAPPsQAEKLYPELTGDLVAd------GFKTVSVKTItGKMEGVYDWIALNYLKNtlas-psknTFG 168 Gammaproteobact...
OGV18485     105 DIEVYVLATAGLRIVSPkEREIFYTCLTDYIKNk------KFAFAYAGMItGHMEGIFDWVAVNYLLNtfse--dkkSVG 176 Lentisphaerae b...
OGV18574     112 EVEFYGLGTAGMRILSPfDRIALFKSLNDLCATk------GFSKVNVRVLeGHEEGLYDWITVNYLEGtlan--dkeTYC 183 Lentisphaerae b...
OGV25708     101 SIPVYMYATAGMRLLPKeKQDKLYKEVRKWFATq-----nHFQLVQLKTIsGSDEALYAWLSVNYLQDrlkdnaarnTIG 175 Legionellales b...
OGV28427      95 NIPVYFYATAGMRLLPDqEQKVLYQKLQDWFSLh-----kDWNLIDARTIsGKEEGVYGWLATNYSLDtlr---dnyHMG 166 Legionellales b...
WP_152430152  89 PDHLYFYSTAGMRTISAtERNLVNQRVKDALAKr-----fPDADIKVKTItGQTEGAYAWLTANYFNGaffn--sqkTTG 161 Vibrio aquimaris

Feature 1           #####                                       ##                               
4BRK_A       151 VMDMGGASVQIVFPMpknaeiskhNQVELNIYGQNINLYVHSFLGLGQTEMSHQFLNsPSCFANDYPLPDGESGq-GNAP 229 Legionella pneu...
4BRG_A       151 VMDMGGASVQIVFPMpknaeiskhNQVELNIYGQNINLYVHSFLGLGQTEMSHQFLNsPSCFANDYPLPDGESGq-GNAP 229 Legionella pneu...
4BVO_A       156 VMDMGGASVQIVFPMpknaeiskhNQVELNIYGQNINLYVHSFLGLGQTEMSHQFLNsPSCFANDYPLPDGESGq-GNAP 234 Legionella pneu...
WP_016211932 178 ILEMGGASTQITFHPttnv--hnnNITRINLGHRPISIYSASYLGLGQDQLRNQFLNhTTCFPNGYKLPNGKRSqlADYA 255 Piscirickettsia...
OGT26545     169 VLDMGGASTEIAFATqeni--spdNKFIVNINNHTYQLYSHSYLGLGQDVARSQYTSnANCFPVGYALPSGSAGn-GDYS 245 Gammaproteobact...
OGV18485     177 VLDLGGGSTQIAFETqev----siFESKIKIGNKTYNLYSRSYLGIGMDYARYQFSNhPECWPKGYPMPSTHIKadPDFS 252 Lentisphaerae b...
OGV18574     184 ILDLGGGSAEIAYEVpda---iypDTFKVTMAGKTFNVYSKSYLGLGMDFVRYQISQlPYCWQTGYPMPSDDQPahANFF 260 Lentisphaerae b...
OGV25708     176 VLDTGGSSVQIAFAVpnedkispdDLKHFKLYGKTINLFVHSFLGLGRTDLGHQLIDeSDCYTKGYQLISGKIGtgNYLI 255 Legionellales b...
OGV28427     167 FIEIGGASTQIVFPVvnlegihpeDLVNLHLYNKDITLFAHSFLGLGANAITTRFKDySDCFPVGYHLDNNQIGs-GNAR 245 Legionellales b...
WP_152430152 162 IMDLGGASTQITFETnt-----gdDLFNVTVGNLNFTLSSTSYLGLGQNLAISQYLNqAACFPKDYPLPNDQLGt-GEFG 235 Vibrio aquimaris

Feature 1                                           ##  ##                                       
4BRK_A       230 SCKEEVTSLMNSVHkvnqqiqpllalnpVNEWYSIGGISYLASSqlfhfenSELTNQSLLQQGDNQIChqqWDILNGQYP 309 Legionella pneu...
4BRG_A       230 SCKEEVTSLMNSVHkvnqqiqpllalnpVNEWYSIGGISNLASSqlfhfenSELTNQSLLQQGDNQIChqqWDILNGQYP 309 Legionella pneu...
4BVO_A       235 SCKEEVTSLMNSVHkvnqqiqpllalnpVNEWYSIGGISNLASSqlfhfenSELTNQSLLQQGDNQIChqqWDILNGQYP 314 Legionella pneu...
WP_016211932 256 TCQRSINPLITKVHqvqpin---nlidsNKTFNALSGFSYTAQFf-----kLQSLSADLLKQKGKQFCstsWDQLQKTYP 327 Piscirickettsia...
OGT26545     246 ACAQRIAPLVEQVQhvhla-----lfpkANRFYAISGFYYTATAkpf-nsnDGTMTLSKLANSGKAFChtnWSTLKNLYP 319 Gammaproteobact...
OGV18485     253 EGVRDFSMLINLFHnlngyk--dlnppdDMDFIGIRGYYHVANAkal--hlNSTFTLKELQQAGTNFSklsWQELEKNYP 328 Lentisphaerae b...
OGV18574     261 KGVDDLSILITLANrsgsfl--apdippDMQIIGLGGFYYLTKSkpl--nlPKDYCINDIVGSGNKLSkesWISLLQNYK 336 Lentisphaerae b...
OGV25708     256 NCTEKIDLLLKVHNvastvkp-vleksdVKEWYVMGGASYLAATspfhfsnNVLQPLTLMTVGAPYYCktpWDVLTNQFI 334 Legionellales b...
OGV28427     246 LCEHEIYELINADNyisdierpaninnpQTKWYTVGAASSISRKspi-nfqDEFNADELLEKADSVYCktnWDTQVSEYG 324 Legionellales b...
WP_152430152 236 ECAEKVEPLINDVQsvntks---aqlgaGSDLYAISGFFFNSSElg----iNDSFSLSKLKETGKHFCsqpWEEVEQGKT 308 Vibrio aquimaris

Feature 1              #   #  #   #                                       
4BRK_A       310 DD---EYLYQYCLLSSYYYALMvdgyginpnqt----ihyippeqnlDWTIGVVLHR 359 Legionella pneumophila
4BRG_A       310 DD---EYLYQYCLLSSYYYALMvdgyginpnqt----ihyippeqnlDWTIGVVLHR 359 Legionella pneumophila
4BVO_A       315 DD---EYLYQYCLLSSYYYALMvdgyginpnqt----ihyippeqnlDWTIGVVLHR 364 Legionella pneumophila
WP_016211932 328 NN---PFLYTYCINSAYFSRLLsrgyqfpsnati-ipthtnrdgsniSWTRGALIYL 380 Piscirickettsia salmonis
OGT26545     320 DD---KYMYGYCFNTAYYDVLLrqgyrfgvqggdqlsvaksiddtdiDWTLGVALLK 373 Gammaproteobacteria bacterium RIFCSPHI...
OGV18485     329 DD---PYLFAHLIHLQLITALFkyeydfhsdkei--qtcnkingtavSLALGAAIYF 380 Lentisphaerae bacterium GWF2_38_69
OGV18574     337 LG---PYTFEYLFESEYIAALLkngfhfsnsrii--harnrinemdsDWTLGAALYV 388 Lentisphaerae bacterium GWF2_38_69
OGV25708     335 ND---PYLEDYCLSSVYFAKLFidgyglyenqd----iqfnkdaateGWTLGVILMH 384 Legionellales bacterium RIFCSPHIGHO2_1...
OGV28427     325 DD---KFLNQNCIISSFIYSLSvesygfspqqe----iynipenqtgDWTVGVLFSS 374 Legionellales bacterium RIFCSPHIGHO2_1...
WP_152430152 309 DYklnPHLYAGCFNAAYQYTLIskgyqltddtnh-itpirelkgnaiSWTLGPVLAP 364 Vibrio aquimaris

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