6G2D,1PIX


Conserved Protein Domain Family
Carboxyl_trans

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pfam01039: Carboxyl_trans 
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Carboxyl transferase domain
All of the members in this family are biotin dependent carboxylases. The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognized types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide. All of the members in this family utilize acyl-CoA as the acceptor molecule.
Statistics
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PSSM-Id: 426008
Aligned: 27 rows
Threshold Bit Score: 371.976
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6G2D_C       1730 PEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEgIPRIYVSANSGARIGLAEEIRHMFHVAWVDPEDPYKGY 1809 human
P9WQH9         12 avLDRGSFVSWDSEPLAVPVAD--SYARELAAARAATG-----ADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAE 84   Mycobacterium...
KIS67530     1546 PEYPAGRKLVVIGNDVTIQAGSFGPVEDRFFAAASKLARELgVPRLYISANSGARIGLATEALDLFKVKFVGD-DPAKGF 1624
XP_002296083 1470 PEYPEGREVVFISNDITVQSGSFGVAEDEVFFKASKYAREHkLPRVYISCNSGARIGLVEDLKPKFKIKFVDEASPSKGF 1549
P78820       1615 PEYPNGRKIIVVANDITFQIGSFGPQEDEYFYKVTQLARQRgIPRIYLAANSGARIGVADEIVPLFNIAWVDPDSPEKGF 1694 Schizosacchar...
Q00955       1574 PEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRgIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGF 1653 Saccharomyces...
XP_663730    1606 PEYPEGRRFIIVANDITFQIGSFGPLEDKFFHKCTELARKLgIPRVYLSANSGARIGMADELIPYFSVAWNDPAKPEAGF 1685
O00763       1780 QEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMARAEgIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGF 1859 human
P32874       1619 PEYPEGRNMIVISNDITYNIGSFGPREDLFFDRVTNYARERgIPRIYLAANSGAKLGIAEELIPLFRVAWNDPSDPTKGF 1698 Saccharomyces...
1PIX_B         54 DVNKRGELTALQRIEKLVEPGSWRPLNTLFNPQGNKNG------SVAIVKGLGRVNGKWCVVVASDNKKLAGAWVPGQAE 127  Acidaminococc...
6G2D_C       1810 RylyLTPQDYKRVSAlnsvhc---ehvedeGESRYKITDIIGKee---gIGPENLRGSGMIAGESSLAYN-EIITISLVT 1882 human
P9WQH9         85 R---ITAAVERATAE---------------RLPLLASPSSGGTrm---qEGTVAFLQMVKIAAAIQLHNQaRLPYLVYLR 143  Mycobacterium...
KIS67530     1625 EyiyLDDESLQAVQAkapnsvmtkpvqaadGSVHNIITDIIGKpq--ggLGVECLSGSGLIAGETSRAKD-QIFTATIIT 1701
XP_002296083 1550 E---YLYLDDETYKTlpegs-----vnvreVPEGWAITDIIGTne---gIGVENLQGSGKIAGETSRAYD-EIFTLSYVT 1617
P78820       1695 DyiyLTPEAYERLQKenpniltteevvtetGELRHKITTIIGSse---gLGVECLRGSGLIAGVTSRAYN-DIFTCTLVT 1770 Schizosacchar...
Q00955       1654 QylyLTSEGMETLKKfdkensvltertvinGEERFVIKTIIGSed---gLGVECLRGSGLIAGATSRAYH-DIFTITLVT 1729 Saccharomyces...
XP_663730    1686 KylyLTPEVKKKFDAskqkevi-telihdeGEERHKITTIIGAkd---gLGVECLKGSGLIAGATSRAYE-DIFTITLVT 1760
O00763       1860 KylyLTPQDYTRISSlnsvhc---khieegGESRYMITDIIGKdd---gLGVENLRGSGMIAGESSLAYE-EIVTISLVT 1932 human
P32874       1699 QylyLAPKDMQLLKDsgkgnsvvvehkmvyGEERYIIKAIVGFee---gLGVECLQGSGLIAGATSKAYR-DIFTITAVT 1774 Saccharomyces...
1PIX_B        128 C---LLRASDTAKTL---------------HVPLVYVLNCSGVkfdeqeKVYPNRRGGGTPFFRNAELNQlGIPVIVGIY 189  Acidaminococc...
6G2D_C       1883 CRAIGIGAYLVRLGQRTIQVEN--SHLILTGAGALN--------------KVLGr-EVYTSNNQLGGIQIMHNNGVTHCT 1945 human
P9WQH9        144 HPTTG-GVFASWGSLGHLTVAEpgALIGFLGPRVYE--------------LLYGdpFPSGVQTAENLRRHGIIDGVVALD 208  Mycobacterium...
KIS67530     1702 GRSVGIGAYLARLGERVIQVEG--SPLILTGYQALN--------------KLLGr-EVYTSNLQLGGPQIMYKNGVSHLT 1764
XP_002296083 1618 GRSVGIGAYLVRLGQRVIQMKQ--GPMLLTGYGALN--------------KLLGr-GVYNSNDQLGGPQVMYPNGCSHEI 1680
P78820       1771 CRAVGIGAYLVRLGQRAVQIEG--QPIILTGAPALN--------------KVLGr-EVYTSNLQLGGTQVMHRNGISHLT 1833 Schizosacchar...
Q00955       1730 CRSVGIGAYLVRLGQRAIQVEG--QPIILTGAPAIN--------------KMLGr-EVYTSNLQLGGTQIMYNNGVSHLT 1792 Saccharomyces...
XP_663730    1761 CRSVGIGAYLVRLGQRAIQVEG--QPIILTGAPAIN--------------KLLGr-EVYTSNLQLGGTQIMYRNGVSHMT 1823
O00763       1933 CRAIGIGAYLVRLGQRVIQVEN--SHIILTGASALN--------------KVLGr-EVYTSNNQLGGVQIMHYNGVSHIT 1995 human
P32874       1775 CRSVGIGSYLVRLGQRTIQVED--KPIILTGASAIN--------------KVLGt-DIYTSNLQIGGTQIMYKNGIAHLT 1837 Saccharomyces...
1PIX_B        190 GTNPAGGGYHSISPTVIIAHEKanMAVGGAGIMGGMnpkghvdleyaneiADMVd-RTGKTEPPGAVDIHYTETGFMREV 268  Acidaminococc...
6G2D_C       1946 VCDDFEGVFTVLHWLSYMPksvHS----SVPLLNSKDPIDRiiEFVPT--KTPYDPRWMLAGRPHptqkgqwlsgffdYG 2019 human
P9WQH9        209 RLRPMLDRALTVLIDAPEPlpaPQtp-aPVPDVPTWDSVVA--SRRPD---RPGVRQLLRHGATD-------------RV 269  Mycobacterium...
KIS67530     1765 AQDDLDAVRSFVNWISYVPaqrGG----PLPIMPTTDSWDRavTYQPP--RGPYDPRWLINGTKAedgtkl--tglfdEG 1836
XP_002296083 1681 VDDDQQGVQSIIQWLSFVPkttDS----ISPVRECADAVNRdvEFRPT--PTPYDPRLMLTGTDDeag-------ffdKG 1747
P78820       1834 SQDDFDGISKIVNWISYIPdkrNN----PVPISPSSDTWDRdvEFYPS--QNGYDPRWLIAGKEDedsfl---yglfdKG 1904 Schizosacchar...
Q00955       1793 AVDDLAGVEKIVEWMSYVPakrNM----PVPILETKDTWDRpvDFTPTn-DETYDVRWMIEGRETesgfe---yglfdKG 1864 Saccharomyces...
XP_663730    1824 AANDFDGVEKIVDWLAFVPekkGS----LPPIRPLADPWDRdvSYHPPa-KQAYDVRWLINGKEDeegfl---pglfdAG 1895
O00763       1996 VPDDFEGVYTILEWLSYMPkdnHS----PVPIITPTDPIDReiEFLPS--RAPYDPRWMLAGRPHptlkgtwqsgffdHG 2069 human
P32874       1838 ASNDMKAIEKIMTWLSYVPakrDM----SPPLLETMDRWDRdvDFKPAk-QVPYEARWLIEGKWDsnnnfq--sglfdKD 1910 Saccharomyces...
1PIX_B        269 YASEEGVLEGIKKYVGMLPkydPEffrvDDPKAPAFPADDLy-SMVPLndKRAYDIYNVIARLFD-------------NS 334  Acidaminococc...
6G2D_C       2020 SFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRtvelsipadpanldseakiiQQAGqVWFPDSAFKTYQAIKDFNR-EG 2098 human
P9WQH9        270 LLSGTDQGEAATTLLALARFGGQPTVVLGQQRA--------------------VGGGgSTVGPAALREARRGMALAAeLC 329  Mycobacterium...
KIS67530     1837 SFVETLGGWATSVVTGRARLGGIPVGVIAVETRtlervvpadpanpnsteqriMEAGqVWYPNSAYKTAQAIWDFDK-EG 1915
XP_002296083 1748 SFKEYLGGWGKSVVIGRGRLGGIPMGAISVETRlvekivpadpadpnsreavlPQAGqVLFPDSSYKTAQALRDFNN-EG 1826
P78820       1905 SFQETLNGWAKTVVVGRARMGGIPTGVIAVETRtientvpadpanpdsteqvlMEAGqVWYPNSAFKTAQAINDFNHgEQ 1984 Schizosacchar...
Q00955       1865 SFFETLSGWAKGVVVGRARLGGIPLGVIGVETRtvenlipadpanpnsaetliQEPGqVWHPNSAFKTAQAINDFNNgEQ 1944 Saccharomyces...
XP_663730    1896 SFEEALGGWARTVVVGRARLGGIPMGVIAVETRsvenvtpadpanpdsmemitQEAGgVWYPNSSFKTAQALRDFNNgEQ 1975
O00763       2070 SFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRtvevavpadpanldseakiiQQAGqVWFPDSAYKTAQAVKDFNR-EK 2148 human
P32874       1911 SFFETLSGWAKGVIVGRARLGGIPVGVIAVETKtieeiipadpanldssefsvKEAGqVWYPNSAFKTAQTINDFNYgEQ 1990 Saccharomyces...
1PIX_B        335 ELHEYKKGYGPEMVTGLAKVNGLLVGVVANVQGllmnype-------ykaagsVGIGgKLYRQGLVKMNEFVTLCAR-DR 406  Acidaminococc...
6G2D_C       2099 LPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPqaELRGGSWVVIDSSINPR-HMemyADR-ESRG 2176 human
P9WQH9        330 LPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLG--QGSGGPALAMLPADRVLaAL---HGW----L 400  Mycobacterium...
KIS67530     1916 LPLVILANWRGFSGGQQDMYDEILKQGSKIVDGLSSYKQPVFVHIPPmgELRGGSWVVVDSAINDNgMIemsADVnSARG 1995
XP_002296083 1827 LPVMIFANWRGFSGGSRDMSGEILKFGSMIVDALREYKHPIYIYFPPhgELRGGSWVVVDPTINEEkMTm--FSDpDARG 1904
P78820       1985 LPLFILANWRGFSGGQRDMFNEVLKYGSYIVDALASYKQPVFVYIPPfsELRGGSWVVVDPTINED-QMemyADE-ESRA 2062 Schizosacchar...
Q00955       1945 LPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPtgELRGGSWVVVDPTINAD-QMemyADV-NARA 2022 Saccharomyces...
XP_663730    1976 LPVMILANWRGFSGGQRDMYNEVLKYGSYIVDALVKYEQPIFVYIPPfgELRGGSWVVVDPTINPD-QMe-mYADeEARG 2053
O00763       2149 LPLMIFANWRGFSGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPyaELRGGSWVVIDATINPL-CIe-mYADkESRG 2226 human
P32874       1991 LPLIILANWRGFSGGQRDMYNEVLKYGSFIVDALVDYKQPILIYIPPfgELRGGSWVVIDPTINPE-QMemyADV-ESRG 2068 Saccharomyces...
1PIX_B        407 LPIVWIQDTTGIDVGNDAEKAELLGLGQSLIYSIQTSHIPQFEITLR--KGTAAAHYVLGGP-QGNdTNafsIGTaATEI 483  Acidaminococc...
6G2D_C       2177 SVLEPEGTVEIKFRRKDLVKTmrrvd-----pvyiHLAERlgtpels-taerkeLENKLKEREEFLIPIYHQVAVQFADL 2250 human
P9WQH9        401 APLPPEGASAIVFRDTAHAAE---------------LAA----------------AQGIRSADLLKSGIVDTIVPEYPDA 449  Mycobacterium...
KIS67530     1996 GVLEASGLVEIKYRADKQRATmerldsv-----yaklskEaaeatd--ftaqttARKALAEREKQLAPIFTAIATEYADA 2068
XP_002296083 1905 GILEPAGIVEIKFRVADQLKAmhridpq-----lqmldaEldatddtdasaqdaIKEQIAAREELLKPVYLQAATEFADL 1979
P78820       2063 GVLEPEGMVSIKFRREKLLSLmrrcd-----hkyaSLCNElkrddls-addlstIKVKLMEREQKLMPIYQQISIHFADL 2136 Schizosacchar...
Q00955       2023 GVLEPQGMVGIKFRREKLLDTmnrld-----dkyrELRSQlsnksla-pevhqqISKQLADRERELLPIYGQISLQFADL 2096 Saccharomyces...
XP_663730    2054 GVLEPEGIVNIKFRRDKQLETmarldptygelrralqdkNlske------klsdIKDKMAAREEQLLPVYMQIALQFADL 2127
O00763       2227 GVLEPEGTVEIKFRKKDLIKSmrrid-----paykKLMEQlgepdls-dkdrkdLEGRLKAREDLLLPIYHQVAVQFADF 2300 human
P32874       2069 GVLEPDGVVSIKYRKEKMIETmirld-----stygHLRRTltekkls-lekqndLTKRLKIRERQLIPIYNQISIQFADL 2142 Saccharomyces...
1PIX_B        484 AVMNGETAATAMYSRRLAKDRka----------gkDLQPTi------------dKMNNLIQAFYTKSRPKVCAELGLVDE 541  Acidaminococc...
6G2D_C       2251 HDTPGRMQEKGVISDILDWKTSRtFFYWRL 2280 human
P9WQH9        450 ADEPIEFALRLSNAIAAEVHALR-KIPAPE 478  Mycobacterium tuberculosis H37Rv
KIS67530     2069 HDRAGRMLATGVLRSALPWENARrYFYWRL 2098
XP_002296083 1980 HDKTGRMKAKGVIKEAVPWARSReYFFYLA 2009
P78820       2137 HDRVGRMVAKKVVRKPLKWTEARrFFYWRL 2166 Schizosaccharomyces pombe 972h-
Q00955       2097 HDRSSRMVAKGVISKELEWTEARrFFFWRL 2126 Saccharomyces cerevisiae S288C
XP_663730    2128 HDRAGRMQAKNTIRQALSWKNARrFFYWRV 2157
O00763       2301 HDTPGRMLEKGVISDILEWKTARtFLYWRL 2330 human
P32874       2143 HDRSTRMLVKGVIRNELEWKKSRrFLYWRL 2172 Saccharomyces cerevisiae S288C
1PIX_B        542 IVDMNKIRGYVEAFTEAAYQNPE--SICPF 569  Acidaminococcus fermentans
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