5DV7,3P1X,2L33


Conserved Protein Domain Family
DSRM_ILF3_rpt2

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cd19912: DSRM_ILF3_rpt2 
second double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. ILF3 contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Statistics
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PSSM-Id: 380741
Aligned: 10 rows
Threshold Bit Score: 110.895
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:5DV7; Mus musculus ILF3 binds dsRNA, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ##  #            #  ###   #               ####                 
5DV7_C        517 ILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPD 588  house mouse
3P1X_A          1 ILTKHGKNPVXELNEKRRGLKYELISETGGSHDKRFVXEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPD 72   human
2L33_A         11 MLTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPD 82   human
Q6NXA4        523 ILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEIDGQKFQGTGSNKKVAKAYAALAALEKLFPE 594  zebrafish
Q12906        520 ILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPD 591  human
XP_005994194  623 ILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEIDGQKFQGTGSNKKVAKAHAALAALEKLFPN 694  coelacanth
AFK84018      525 ILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPD 596  chicken
Q91550        517 ILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGVKFQGSGSNKKVAKAYAALSALEKLFPD 588  African clawed frog
XP_007909112  531 ILTKQGKNPVMELNEKRRGLKYELISETGGSHDKRFIMEVEVDGQKFKGSGSNKKVAKAYAALAALEKLFPH 602  elephant shark
Q6DD04        517 ILTRHGKNPVMELNEKRRGLKYELISETGGSHDKRFIMEVEVDGVKFQGNGSNKKVAKAYAALSALEKLFPD 588  African clawed frog

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