Conserved Protein Domain Family
PRK02471

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PRK02471: PRK02471 
bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB
Statistics
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PSSM-Id: 179427
Aligned: 55 rows
Threshold Bit Score: 1022.17
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
18310555    6 KGLLKIIKDESLEDYFIKANFGLEKENVRVTESGNLALTPHPKAFGDREKNAYIKTDFSESQLEMVTPVCNTLEEVYSFI 85 
28378916    4 DAVGKAIVQYHLVPLVHQANLGLEVTMHRVDAHGHLATTAHPQAFGSAQQNHQLRPGFSASALKFTTPVRRDIPALMAYL 83 
81428451    3 NQLFEQIQQLHLAPLLNWGAFGIEKEGHRVTAAGQLSPLSHPASLGSRDFHPYIKTDFAEMQTELVSDTFDNTDEIMQQL 82 
46908959    7 TMLDSFKEDPKLRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDSVYEWL 86 
217966024   7 TMLDSFKENPTLRKYLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDSVYEWL 86 
226225322   7 TMLDSFKEDPKLRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDSVYEWL 86 
284800343   7 TMLDSFKEDPNLRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDSVYEWL 86 
289436043   7 TMLDYFKESPTLQKQLFSGHFGLEKENVRVTADGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDTVYEWL 86 
16801972    7 TMLDSFKENEALRKYLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDAVYEWL 86 
116874133   7 TILDSLKENKALRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDDVYNWL 86 
18310555   86 CNLNKVVSLEImKNGEFLWPQSNPPILPR-EEEIPIAKLSN--REDELYRENLSYKYGKKKQVISGIHYNFSFKEEFIKL 162
28378916   84 KGLNTAARRSL-DADERLWPLSSTPVLPDdLTNVPLADVD---QVSYQRRRDLARKYELQRLMTTGSHVNMSLNEALFTR 159
81428451   83 GALSEVLEMNL-ADDELIWPLSMPPVLPSdETTIPIADVA---PDARAYRDYLANRYGRRLQMISGVHFNFSLAPALIAR 158
46908959   87 ENLHNIVSLRS--ENELLWPSSNPPILPA-EEDIPIAEYKTpdSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDG 163
217966024  87 ENLHNIVSLRS--ENELLWPSSNPPILPA-EEDIPIAEYKTpdSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDG 163
226225322  87 ENLHNIVSLRS--ENELLWPSSNPPILPA-EEDIPIAEYKTpdSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDG 163
284800343  87 ENLHNIVSLRS--ENELLWPSSNPPILPA-EEDIPIAEYKTpdSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDG 163
289436043  87 ENLHNIVSLRA--EDELLWPSSNPPILPP-EKDIPIAVYKTpdSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDG 163
16801972   87 ENLHNIVSLRA--ENELLWPSSNPPILPA-EEDIPIAEYKTpdSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDG 163
116874133  87 ENLHNIVSLRS--KNELLWPSSNPPILPA-EKDIPIAEYKTpdSPDRKYREHLAQGYGKKIQLLSGIHYNFSFPEALIDG 163
18310555  163 LYKELKVEKD--FREFKDDIYLRMARNFQKYHWLLIYLTGASPVFHESYIEEIKEegeklgedsYYIKDDTSLRNS-SYG 239
28378916  160 LYTETFHQQYhsYVDFRNAIYLKVAQGLVRMNWLIQYLFGASPRLA------------------VTDTTSRPQRSSvQHP 221
81428451  159 LYDEVYHDQFatVKDFSDMLYLQIAQNYSQYRYLLTYLFGASPITEALFQTDTTN---------LPDYAVRSLRSSqLFG 229
46908959  164 LYDKISLPEEs-KQDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFSKTKHDeslp--dgsSALRDGISLRNS-NAG 239
217966024 164 LYDKISLPEEs-KQDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFSKTKHEeslp--dgsSALRDGISLRNS-NAG 239
226225322 164 LYDRISLPEEs-KQDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFSKTKHDeslp--dgsSALRDGISLRNS-NAG 239
284800343 164 LYANISLPEEs-KQDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFSKTKHEeslp--dgsSALRDGISLRNS-NAG 239
289436043 164 LYSQISLPEEs-KQDFKNRLYLKVAKYFMKNRWLLVYLTGASPVYLADFTTTKNEetla--dgsSSFRDGISLRNS-NAG 239
16801972  164 LYAEISHPNEs-KRDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFTKTNSEevln--dgsKALHRGISLRNS-NAG 239
116874133 164 LYDEISLPNEs-KRDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFTKTKQEeklr--dgsSALHDGISLRNS-NAG 239
18310555  240 YKNKKDYYVSYNSIEEYASDIKNLVKDKEIQSIKEYYNPIRLKSLGSEDmleSLLHKGIDYLEVRLLDLDPLSIQGVSKE 319
28378916  222 DGRYSQVTGDYTSIDRYVAKLTAAVRQQQLLSVNDFDGPVRLRSNGQLA---MMARQGVYYLEYRGLDLDPTSPVGVDAN 298
81428451  230 YANH-DLVVSFESVAAYHDSLEQAISKKQLISEREYYGSVRLRSHG------HLAQDGVDYLEFRGFDLNPFAASGVTQE 302
46908959  240 YKNKEALYVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQtveSLAEHGVEYLEIRSIDLNPLESNGISKD 319
217966024 240 YKNKEALYVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQtveSLAEHGVEYLEIRSIDLNPLEPNGISKD 319
226225322 240 YKNKEALYVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQtveSLAEHGVEYLEIRSIDLNPLESNGISKD 319
284800343 240 YKNKEALFVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQtveSLAEHGVEYLEIRSIDLNPLEPNGISKD 319
289436043 240 YKNKEALYVDYNSFDAYIASISNYIEQGKIESMREFYNPIRLKNAHTDQtveSLAEHGVEYLEIRSIDLNPLEPNGISKD 319
16801972  240 YKNKESLFVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQtveSLAKHGVEYLEIRSIDLNPLEPNGISKD 319
116874133 240 YKNKESLYVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQtveSLAKHGVEYLEIRSIDLNPLEPNGISKE 319
18310555  320 TLYLLHLFMIYTLLK-ENKEItYKDQEEFFKNHDMVALKGrneeaviyeNGVPVLLKDKGREILSEMDEIVEILFSNNEe 398
28378916  299 AVAFVRLLASYFVMMpALPAKmVSQVNAQADQLTRQVLGEn--------PTTASAQAVPAVQVLDALADFVKTYGLPNE- 369
81428451  303 QLDFLHLFFTYLLSLpKAAESlTARMAEGQQLNEAIALED---------ATKASAQQAKMQMLMTNIRQFITTYQLNQR- 372
46908959  320 ELAFIHLFLIKGLLS-EDRELcSNNQQLADENENNIALNGlaqpalkncDNEEISVVEAGLLELNKMSDFIQSLRPEDTk 398
217966024 320 ELAFIHLFLIKGLLS-EDRELcSNNQQLADENENNIALNGlaqpalkncDNEEISVVEAGLLELNKMSDFIQSLRPEDTk 398
226225322 320 ELAFIHLFLIKGLLS-EDRELcSNNQQLADENENNIALNGlaqpalkncDNEEISVVEAGLLELNKMSDFIQSLRPEDTk 398
284800343 320 ELDFIHLFLIKGLLS-EDRELcANNQQLADENENNIALNGlaqpsikncDNEDIPLADAGLLELDKMSDFIKSLRPEDTk 398
289436043 320 ELTFIHLFLIKGLLS-EDRELcNNNQQLADENENTVALNGlaqpaiktcDNEEVSLSEAGLLELTKMSDFISTLLPDDTy 398
16801972  320 ELIFIHLFLIKGLLS-EDRELcANNQQLADENENNIALNGlaqpaikncDNEEMSLADAGLLELDKMSDFIQSLIPNDNh 398
116874133 320 ALHFIHLFLIKGLLS-EDRELcENNQQLADENENNIALNGlskpaikncDNEEMALADAGLLELDKMNDFIQSLRPEDTy 398
18310555  399 FKNVIKRALEKINNPHDTISEKLIKDIKEEGYINFHMRLAKEYLNNFKNKEFNLVGYEDLELSTQILILDAIKRGIEFNI 478
28378916  370 DAVLLKQLKSWVTDPKKTLSAQIAMQADP---LAWALERAARYQESSNERPFELAGFTALDLSSQQLAQQALTRGVQVDV 446
81428451  373 FIDAWTVMNERVNDFKQTLSYRLAQEVQDDSLTAFAMQQARQFKRELTEKPFQLQGYTDMELSTQMLMLDAFQKGLHVAV 452
46908959  399 LQAIIEKQKERLLHPEKTIAAQVKQQVTKEGYVDFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDV 478
217966024 399 LQAIIEKQKERLLHPEKTIAAQVKQQVTKEGYVDFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDV 478
226225322 399 LQAIIEKQKERLLHPEKTIAAQVKQQVTKEGYVDFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDV 478
284800343 399 LRAIIEKQKERLLHPEKTIAAQVKQQVTKEGYVDFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDV 478
289436043 399 FSSIIEKQKERLLHPEKTIAYQVIEHVKTTGYVDFHLNQAKIFMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDV 478
16801972  399 FQAIIEKQKERLLHPEKTIAAQVQAQSAKEGYVEFHLNQAKTYMEETEALAYKLVGAEDMELSTQIIWKDAIARGIKVDV 478
116874133 399 FQAIIEKQKERLLHPEKTIAAQVKEQSATAGFIEFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDV 478
18310555  479 MDRLENFISLSDGEKVEYVKQATKTSKDSYITALIMENKLVTKDILRENNIRVPKGKDYDNIDEAKKDFR-LFKDEKIVI 557
28378916  447 VDPHANILRLTKLGRSQLVVNGSGTDLNPQALTTVLTHKAAAKQILAEHGVPVPASQTYHTANQLIADYDrYVQAGGIVL 526
81428451  453 LDRSDQFVELTYQQHHELVKNGNMTSLDRLISWPLVDNKVVTKIVLANQGIRVPAGAEYADLEVAKRDYQaAFGQRALVI 532
46908959  479 LDRAENFLRFQKGDHVEYVKQASKTSKDNYVSVLMMENKVVTKLVLAEHDIRVPFGDSFSDQALALEAFS-LFEDKQIVV 557
217966024 479 LDRAENFLRFQKGDHVEYVKQASKTSKDNYVSVLMMENKVVTKLVLAEHDIRVPFGDSFSDQALALEAFS-LFEDKQIVV 557
226225322 479 LDRAENFLRFQKGDHVEYVKQASKTSKDNYVSVLMMENKVVTKLVLAEHDIRVPFGDSFSDQALALEAFS-LFEDKQIVV 557
284800343 479 LDRAENFLRFQKGDHIEYVKQASKTSKDNYVSVLMMENKVVTKLVLAEHDIRVPFGDSFSDQALALEAFS-LFEDKQIVV 557
289436043 479 LDRAENFLRFQKGDHVEYVKQASKTSKDNYVSVLMMENKVVTKLILAENGIRVPFGDSFSDQAAALEAYS-LFQNKQIVV 557
16801972  479 LDRAENFLRFQKGDHVEYVKQASKTSKDNYVSVLMMENKVVTKLVLAEHGIRVPFGDSFSDQALALEAFS-LFEDKQIVV 557
116874133 479 LDRAENFLRFQKGDHVEYVKQASKTSKDNYVSVLMMENKVVTKLVLAENNIRVPFGDSFSDQALALEAFS-LFKDKQIVV 557
18310555  558 KPKSTNFGLGISIFPGEYSREDYDKAVEIAFREDSSILIEEFMTGKEYRFLVIGEEVVGILHREPANVIGNGESTIEELV 637
28378916  527 KAADESH--KVIVFRIMPERGLFEQVVRQLFEQTSAVMAEEVVVASSYRFLVIDSRVQAIVERIPANIVGDGRSTVKTLL 604
81428451  533 KPKTSNMGAGITTFLTRPSETDFVTAFKLAQQYDQQVLVEEYIAGSEYRFLVMDHQVQAVLERVPANVVGDGRSTITQLV 612
46908959  558 KPKSTNYGWGISIFKNKFTLEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELV 637
217966024 558 KPKSTNYGWGISIFKNKFSLEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELV 637
226225322 558 KPKSTNYGWGISIFKNKFTLEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELV 637
284800343 558 KPKSTNYGWGISIFKNKFTLEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELV 637
289436043 558 KPKSTNYGWGISIFKNKFTKDDYQQALKIAFSYDKSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELV 637
16801972  558 KPKSTNYGWGISIFKNKFTLEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRQLV 637
116874133 558 KPKSTNYGWGISIFKNKFTTEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELV 637
18310555  638 SEKNKDPLRGKGYKTPLEKIKLGEIEEMFLKNQGLSFKSIPKNGEKIYLRENSNISTGGDSIDFTDKIHPSYKEVALKSA 717
28378916  605 DRKNGRALRGTAFKWPQSALQLGTIERYRLDSYHLTLDSVVSRGTQILLREDATFGNGADVLDATADMHQSYVQAVEKLV 684
81428451  613 AKKNRNELRGEDHRTPLQNIRLGAREQLILKQQGYQVDDVPMRGSQVFLLQNSNISNGGDSVDVTDDIDKSYFAIAEKVA 692
46908959  638 EEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDSIPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRAT 717
217966024 638 EEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDSIPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRAT 717
226225322 638 EEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDSIPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRAT 717
284800343 638 EEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDSIPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRAT 717
289436043 638 DEKNTDPLRGTDHLKPLEEIQTGPEETLMLSMQKLSWDSIPESGKTIYLRENSNVSTGGDSIDYTAEMDDYFKEIAIRAT 717
16801972  638 EEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDSIPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRAT 717
116874133 638 EEKNMDPLRGTDHLKPLEKIRTGPEETLMLSMQKLSWDSIPKANETIYLRENSNVSTGGDSIDYTAEMDDYFKEIAIRAT 717
18310555  718 KAVKALICGVDMVIDNIEEEAKEK--NHGI-IELNFNPAIHIHCFPYKGENRKAGEKILDLLFN 778
28378916  685 ADLHLAVAGVDVMIPNLYAELVPEhpEMAVyLGIHAAPYLYPHLFPMFGTAQPVAGQLLDALFK 748
81428451  693 EILNLNVTGVDIIIPNLYQPYDPEhpEMAVvLEANYNPAMLMHLFPMMGQQRRVTTKMLTMLFP 756
46908959  718 QVLDAKICGVDIIVPRETIDRD----KHAI-IELNFNPAMHMHCFPYQGEKKKIGDKILDFLFE 776
217966024 718 QVLDAKICGVDIIVPRETIDRD----KHAI-IELNFNPAMHMHCFPYQGEKKKIGDKILDFLFE 776
226225322 718 QVLDAKICGVDIIVPRETIDRD----KHAI-IELNFNPAMHMHCFPYQGEKKKIGDKILDFLFE 776
284800343 718 QVLDAKICGVDIIVPRETIDRD----KHAI-IELNFNPAMHMHCFPYQGEQKKIGDKILDFLFD 776
289436043 718 QVLDAKICGVDIIVPRETINRD----KHAI-IELNFNPAMHMHCFPYQGQQKKIGDKILDFLFD 776
16801972  718 QVLDAKICGVDIIVPRETIDRD----KHAI-IELNFNPAMHMHCFPYQGEKKKIGDKILDFLFE 776
116874133 718 QVLDAKICGVDIIVPRETIDRD----KHAI-IELNFNPAMHMHCFPYQGEQKKIGDKILDFLFE 776
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