5XON


Conserved Protein Domain Family
TFIIS_M
?
pfam07500: TFIIS_M 
Transcription factor S-II (TFIIS), central domain
Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.
Links
?
Statistics
?
PSSM-Id: 462184
Aligned: 273 rows
Threshold Bit Score: 45.659
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
5XON_U        26 YENKTRNGSISAIYTALAMDSD--------EQpsKIFELVKDIEKQCFKavnft---vddtYRNKLRSLIMNLknKNNPT 94  Komagataella ph...
EIJ88466       2 DCSDTRRRCKEEFTKVFSQQMEgt-----dSE--RASTLGDLLEEEIHRttst-----raeYGMLFRTKYLNLkdASHKW 69 
ELQ76770      26 KGDQSRDRTTSLFYEVFVSIINdv-----dKL--RAARLASDLEQEIYDnk---------iVSSQIRSKYLNLkdKSN-D 88 
Q8SS71        98 TGDSQKDRSIKMFFDAIKTNISdc-----nNA--SAALLARQITIEIFGrnp-------sdIAKLIRSKCLNLkdKNNPA 163 Encephalitozoon...
EEQ82797       7 FEDPQKNKCMKLFYESLKYNLPsf-----dEE--RLHSLSFELTRSIYKnfs-------ndLPKIVRSKCFNLkdKNNPR 72 
EOB12593      12 FDDPQKNKCMKLFCEAIISNLKdy-----vES--KVNKLSYDLTVSLYEtyf-------tdIPKMVRSKALNLkdKNNPK 77 
XP_002139452 147 TGEPLRDKARQFLWKAFVMGVPvsqaelmdPS--QVCEISAEVESALYKeyiikqgnsvrdYNLQLKTIKWNLgdLKNPE 224
Q8IBV2       226 HNDMHRDKAKQFLFKAFVVGSSdnllyfieKK--KLNDIIYNIECELYKvymekr-ssqkeYNMQLKSIKFNLsdKKNPN 302 Plasmodium falc...
Q4N8B9       151 RNDLHRDKALRYLFRCFLLGQDf------gPEltRLSELINSMELSLYDhyvven-dnrkaYNQQLKCIAFNLkdVKNTI 223 Theileria parva
Q4UH96       245 RNNIYRDKALRYLFDSFIIGKDf------eIEmeELTEKINLIEKSLYNyyiiek-nnqkgYNQQLKCIGFNLkdNKNTI 317 Theileria annulata

5XON_U        95 LRRSILDHEIIPSKLVTMSAQELAPDSLKKEMEEIYKKNLFDA 137 Komagataella phaffii GS115
EIJ88466      70 LCTSVYNGVLAIEKFIAMTGDEMRSKELKELEAKIFQRALLDT 112
ELQ76770      89 LCVGIYEGRIGVHEFLLMSMDEMKSKARRSSDNDLIKSSIEGS 131
Q8SS71       164 LCRRVYNGDISPSRYVDMSSEEMKSESLKNEEVKMIEVSLYEC 206 Encephalitozoon cuniculi
EEQ82797      73 ICKEVYEGTIKPDEYILMSNEDMKSKDLKEQERKAYEESLYDI 115
EOB12593      78 LCKDVYEGKISPDEYIRMSSEEMQSIDLKREVEKAIQDSFYDA 120
XP_002139452 225 LNSKLYIGKITPDEIATMHSREMASEAKQKEREKHKQESLEAC 267
Q8IBV2       303 FNEKVYSEFISSKALATMNSQDMASDEKKNERKKCLQESLLAC 345 Plasmodium falciparum 3D7
Q4N8B9       224 LNYKLYNKMITVDELTRMTSLQMASDEKKLQRNEILEQSLEAC 266 Theileria parva
Q4UH96       318 FNYKLYNNIISINELIHMSSLQMASDEKKLQRNEILEQSLEAC 360 Theileria annulata
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap