GEO DataSets

(Submitter supplied) PCR based detection of trisomy 18 and trisomy 21 compared against results obtained by CGH microarrrays in Preimplantation Genetic Screening

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL17760

21 Samples

Download data: TXT, XLS

(Submitter supplied) PCR based detection of Y-chromosome compared against results obtained by CGH microarrrays in Preimplantation Genetic Screening

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL17760

21 Samples

Download data: TXT

(Submitter supplied) Human embryonic stem cells (hESC) show great promise for clinical and research applications, but genomic instability hampers the development of their full potential. Here we demonstrate that increased culture density causes medium acidification due to lactic acid accumulation. hESC are able to cope with this, but acquire increased DNA damage associated to DNA replication stress. Also, single-cell genomics analysis reveals a strong correlation of the occurrence of de novo CNVs and culture density after only five days of culture. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL17760

59 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL10558 GPL17760

20 Samples

Download data: TXT

(Submitter supplied) The use of in vitro fertilization (IVF) has revolutionized the treatment of infertility and is now responsible for 1-5% of all births in industrialized countries. During IVF, it is typical for patients to generate multiple embryos. However, only a small proportion of them possess the genetic and metabolic requirements needed in order to produce a healthy pregnancy. The identification of the embryo with the greatest developmental capacity represents a major challenge for fertility clinics. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL17760

14 Samples

Download data: TXT

(Submitter supplied) Oocyte vitrification has been introduced into clinical settings without pre-clinical safety testing. In this study, we analyzed the safety of human oocyte

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL17760

48 Samples

Download data: TXT

(Submitter supplied) Ten volunteers underwent 13 research IVM cycles. Immature oocytes were retrieved after mild ovarian stimulation with gonadotropins but no hCG ovulation trigger, in vitro matured and fertilized using ICSI. Oocyte maturation rate in vitro was 47% (94/199), the mean fertilization rate was 71% (67/94) and 37% (25/67) of mature oocytes developed into a morphologically good quality embryo on day 3 after ICSI, after which the blastomeres were analysed by single-cell aCGH. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL17760

123 Samples

Download data: TXT

(Submitter supplied) Although it is known that cultured human cells acquire copy number variations over time, little is known about the mutation frequency in individual cells. Here we describe that human somatic and embryonic stem cell cultures show significant fractions of cells carrying unique chromosomal abnormalities, forming a non-clonal genetic mosaic. We studied 85 human single cells by array-based comparative genomic hybridisation and found that 14-31% of hESC and 8-26% of somatic cells are chromosomally abnormal. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL17760

106 Samples

Download data: TXT