GEO DataSets

(Submitter supplied) Background: Clostridioides difficile (C. difficile) is a global threat and has significant implications for individuals and health care systems. Little is known about host molecular mechanisms and transcriptional changes in peripheral immune cells. This is the first gene expression study in whole blood of patients with C. difficile infection. Methods: We took blood and stool samples from patients with toxigenic C. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

278 Samples

Download data: CEL

(Submitter supplied) Glucocorticoid receptor (GR) has been recently identified as a candidate for acquired anti-androgen and chemotherapy resistance. In order to identify glucocorticoid receptor (GR) targets and studying stromal GR signaling gene expression profiling was performed in primary prostate cancer associated fibroblasts using different treatments.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL23126 GPL24676

26 Samples

Download data: BEDGRAPH, BW, CEL, CHP

(Submitter supplied) The study assessed fibroblast reprogramming into induced pluripotent stem cells (iPS), and the effects on efficiency of iPS reprogramming by treatment with 10-uM PFI-3. Samples were collected across multiple time points during reprogramming: day 0, 3, 5, 7, 14, and day 21, each in the presence or absence of PFI-3 treatment, with n=3 biological replicates.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

39 Samples

Download data: CEL

(Submitter supplied) Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key component of the tumor stroma. Here we show that loss of androgen receptor (AR), which triggers early steps of CAF activation in human dermal fibroblasts (HDFs), leads to nuclear membrane alterations with increased micronuclei formation and frequent ruptures, with similar alterations occurring in fully established CAFs. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

4 Samples

Download data: CEL, CHP

(Submitter supplied) We analyzed the transcriptome profiles of CD19+ B cells and CD4+ T cells from the peripheral blood of patients with multiple sclerosis (MS) immediately before and after relapse therapy with apheresis. High-density Clariom D Arrays for human were used to obtain gene-level and exon-level expression profiles. This GEO entry provides the processed data from the gene-level and exon-level workflows.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

14 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) This study aimed to reveal downstream genes of PROX1 in a carcinoid-derived cell line NCI-H727. We performed gene expression microarray after PROX1 knockdown in NCI-H727 cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

6 Samples

Download data: CEL

(Submitter supplied) Ewing sarcoma (EwS) cell line culture largely relies on standard techniques, which do not recapitulate physiological conditions. Here, we report on a physiologically improved, feasible, and cost-efficient EwS cell culture technique employing an advanced medium composition, reduced fetal calf serum, and spheroidal growth. Functional in vitro assays and transcriptome profiling demonstrated that these refined conditions better recapitulate proliferation rates of patient tumors as well as hypoxic conditions relevant for EwS pathophysiology. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

24 Samples

Download data: CEL

(Submitter supplied) Glioblastoma multiforme (GBM) presents a formidable clinical challenge due to its complex microenvironment. Here, we introduce lipid droplet (LD)-loaded macrophages, or tumor-associated foam cells (TAFs), as a previously unidentified immune cell population in GBM. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we reveal that TAFs exhibit distinct pro-tumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by RT-PCR

Platforms:

GPL33679 GPL23126 GPL18573

45 Samples

Download data: CEL, CHP

(Submitter supplied) This study compares the dose dependent transcriptome data obtained for the volatile compound dimethylamine, which has been exposed in an in vitro system via air-liquid-interface (ALI) exposure to a pulmonary cell line (A549 cells).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

15 Samples

Download data: CEL, CHP

(Submitter supplied) Monocyte-derived dendritic cells (MoDCs) were obtained from two controls and two Down syndrome patients. A microarray-based transcriptomic analysis was performed on the Clariom D Assay, Human platform (ThermoFisher Scientific).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

4 Samples

Download data: CEL

(Submitter supplied) Obstructive sleep apnea (OSA) is common during pregnancy and is associated with adverse perinatal consequences, but it is not known whether it can also modulate fetal development processes. To understand the effects of OSA-affected mothers on fetus we analyzed the expression profile of hUCB cells under OSA conditions.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

10 Samples

Download data: CEL

(Submitter supplied) Oxidative stress has long been postulated to play an essential role in aging mechanisms, and numerous forms of molecular damage associated with oxidative stress have been well documented. However, the extent to which changes in gene expression in direct response to oxidative stress are related to actual cellular aging, senescence, and age-related functional decline remains unclear. We used microarrays to detail H2O2-induced oxidative stress and resulting gene expression alterations in prostate epithelial cells in vitro. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

8 Samples

Download data: CEL, XLSX

(Submitter supplied) The human polyomavirus, JCPyV, establishes a lifelong persistent infection in the peripheral organs of a majority of the human population worldwide. Patients who are immunocompromised due to underlying infections, cancer, or to immunomodulatory treatments for autoimmune disease are at risk for developing progressive multifocal leukoencephalopathy (PML) when the virus invades the CNS and infects macroglial cells in the brain parenchyma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

6 Samples

Download data: CEL

(Submitter supplied) We hypothesized that seminal plasma, the acellular seminal fluid component, influences the endometrium stimulating the immune system and facilitating the implantation. We designed a randomized, double-blinded, placebo-controlled trial, and we used microarray analysis to evaluate differences in the endometrial transcriptomic profile after vaginal seminal plasma application. Differential gene pathways analysis showed an upregulation of pathways associated with the immune response, cell viability, proliferation and cellular movement, implantation, embryo development, oocyte maturation and angiogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

9 Samples

Download data: CEL

(Submitter supplied) T-lymphocytes from visceral and subcutaneous white adipose tissue (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused on this subject. Claudin-1 (CLDN1) is a protein involved canonically in Tight Junctions (TJs) and tissue paracellular permeability. We evaluated the gene expression in T lymphocytes from vWAT and sWAT and in the whole adipose depots.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

22 Samples

Download data: CEL

(Submitter supplied) We examined gene expression variations in monocyte between PsA patients and healthy control subjects

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

4 Samples

Download data: CEL

(Submitter supplied) We analyzed the transcriptome profiles of CD19+ B cells and CD4+ T cells from the peripheral blood of patients with multiple sclerosis (MS) immediately before and after relapse therapy with high-dose methylprednisolone (MP). High-density Clariom D Arrays for human were used to quantify the transcript levels. This GEO entry provides the processed data from the gene-level and exon-level workflows.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

48 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) We demonstrate that DSF/Cu treatment reduced meningioma cell viability and increased intracellular ER stress. We used microarrays to analyze the DSF/Cu regulated gene expression.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

14 Samples

Download data: CEL